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Early pregnancy exposure of maternal triglyceride levels and its effects on birth weight

  • Ou Huang , Dandan Wu ORCID logo EMAIL logo and Min Ji EMAIL logo
Published/Copyright: July 13, 2023
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 36 Issue 8

Abstract

Objectives

The aim of this study was to evaluate the early pregnancy exposure of maternal triglyceride (mTG) and its effects on birth weight, which was an important indicator for nutritional status of newborns, and even its long-term health.

Methods

A retrospective cohort study was designed to investigate the relationship between mTG in early pregnancy and birth weight. Totally 32,982 women who had a singleton pregnancy and underwent serum lipids screening during early pregnancy were included in this study. Logistic regressions were used to evaluate the correlations between mTG levels and small for gestational age (SGA) or large for gestational age (LGA), and the restricted cubic spline models were applied to explore the dose-response relationship.

Results

The increased mTG levels during early pregnancy decreased the risk of SGA and increased the risk of LGA. The high mTG (>90th, 2.05 mM) was showed associated with higher risk of LGA (AOR, 1.35; 95 %CI, 1.20 to 1.50), and lower risk of SGA (AOR, 0.78; 0.68 to 0.89). Lower risk of LGA (AOR, 0.81; 0.70 to 0.92) was found in those cases of low mTG (<10th, 0.81 mM), but no correlation was found between low mTG levels and the risk of SGA. The results remained robust after excluding women with high or low body mass index (BMI) and pregnancy complications.

Conclusions

This study suggested that early pregnancy exposure of mTG were related to the occurrence of SGA and LGA. mTG levels higher than 2.05 mM (>90th) were suggested to be avoid because of its risk for LGA, while mTG lower than 0.81 mM (<10th) showed its benefits for ideal birthweight range.

Keywords: birth weight; large for gestational age; maternal triglyceride; risk factor; small for gestational age
Corresponding author: Dandan Wu and Min Ji, School of Medicine, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, 910 Hengshan Road, Shanghai 200030, P.R. China; and Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, P.R. China, Phone: +86 18121234269 (D. Wu), +86 18017316193 (M. Ji), E-mail: ,

Funding source: Clinical Research Plan of IPMCH

Award Identifier / Grant number: IPMCH2022CR1-03

Funding source: Shanghai Municipal Key Clinical Specialty

Award Identifier / Grant number: shslczdzk06302

Acknowledgments

The authors thank the patients who participate in this study, also physicians and nursing staffs providing support for this project.

  1. Research funding: This work was supported by the Clinical Research Plan of IPMCH (IPMCH2022CR1-03) and Shanghai Municipal Key Clinical Specialty (shslczdzk06302).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The research protocol was authorized by the Ethics Committee of International Peace Maternal Health Hospital.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jpem-2023-0035).

Received: 2023-01-26
Accepted: 2023-06-30
Published Online: 2023-07-13
Published in Print: 2023-08-28

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Metabolic risk factors in prepubertal and pubertal patients with overweight and obesity
  4. Blood pressure in girls with central precocious puberty receiving GnRH analogue therapy
  5. Norethindrone dosing for adequate menstrual suppression in adolescents
  6. Apparent diffusion coefficient (ADC) measurements and morphometric evaluation of the cranium in age-matched children with central precocious puberty
  7. Characteristics of vitamin D deficiency hypocalcemia inpatient admissions at a single tertiary center
  8. Early pregnancy exposure of maternal triglyceride levels and its effects on birth weight
  9. Evaluation of the clinical, biochemical, and genetic presentation of neonatal and adult-onset 5,10-methylene tetrahydrofolate reductase (MTHFR) deficiency in patients from Pakistan
  10. Congenital hypothyroidism in Bogotá, Colombia: a current description (2015–2021)
  11. Case Reports
  12. Case report: mitochondrial diabetes mellitus in a Chinese family due to m.3243A>G
  13. Novel pathogenic variant of DICER1 in an adolescent with multinodular goiter, ovarian Sertoli–Leydig cell tumor and pineal parenchymal tumor of intermediate differentiation
  14. Fibroblast growth factor 23 levels in cord and peripheral blood during early neonatal period as possible predictors of affected offspring of X-linked hypophosphatemic rickets: report of three female cases from two pedigrees
  15. A rare cause of hyperphenylalaninemia: four cases from a single family with DNAJC12 deficiency
  16. The benefit of rhGH therapy in a Chinese child with 12q14 microdeletion syndrome: a case report
  17. Adjustment of octreotide dose given via insulin pump based on continuous glucose monitoring (CGM) in a child with congenital hyperinsulinism
https://doi.org/10.1515/jpem-2023-0035
Keywords for this article
birth weight; large for gestational age; maternal triglyceride; risk factor; small for gestational age

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Metabolic risk factors in prepubertal and pubertal patients with overweight and obesity
  4. Blood pressure in girls with central precocious puberty receiving GnRH analogue therapy
  5. Norethindrone dosing for adequate menstrual suppression in adolescents
  6. Apparent diffusion coefficient (ADC) measurements and morphometric evaluation of the cranium in age-matched children with central precocious puberty
  7. Characteristics of vitamin D deficiency hypocalcemia inpatient admissions at a single tertiary center
  8. Early pregnancy exposure of maternal triglyceride levels and its effects on birth weight
  9. Evaluation of the clinical, biochemical, and genetic presentation of neonatal and adult-onset 5,10-methylene tetrahydrofolate reductase (MTHFR) deficiency in patients from Pakistan
  10. Congenital hypothyroidism in Bogotá, Colombia: a current description (2015–2021)
  11. Case Reports
  12. Case report: mitochondrial diabetes mellitus in a Chinese family due to m.3243A>G
  13. Novel pathogenic variant of DICER1 in an adolescent with multinodular goiter, ovarian Sertoli–Leydig cell tumor and pineal parenchymal tumor of intermediate differentiation
  14. Fibroblast growth factor 23 levels in cord and peripheral blood during early neonatal period as possible predictors of affected offspring of X-linked hypophosphatemic rickets: report of three female cases from two pedigrees
  15. A rare cause of hyperphenylalaninemia: four cases from a single family with DNAJC12 deficiency
  16. The benefit of rhGH therapy in a Chinese child with 12q14 microdeletion syndrome: a case report
  17. Adjustment of octreotide dose given via insulin pump based on continuous glucose monitoring (CGM) in a child with congenital hyperinsulinism
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