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Dehydroepiandrosterone sulfate levels at 7 years old and cardio-metabolic factors at 10 and 13 years old – the generation XXI birth cohort

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Veröffentlicht/Copyright: 5. Mai 2023
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 36 Heft 6

Abstract

Objectives

Premature adrenarche is often linked to a cluster of endocrine-metabolic risk factors. Our objective was to explore the association of dehydroepiandrosterone sulfate (DHEAS) levels at age 7 with cardio-metabolic traits at ages 10 and 13, independently of adiposity and pubertal stage.

Methods

Longitudinal study of 603 individuals (301 girls/302 boys) from the Generation XXI birth cohort. DHEAS at age 7 was measured by immunoassay. Anthropometrics, pubertal staging, blood pressure, and metabolic outcomes were evaluated at ages 7, 10, and 13. Pearson correlations between DHEAS and cardio-metabolic traits (insulin, HOMA-IR, triglycerides, LDL-cholesterol, high-sensitivity C-reactive protein, and systolic and diastolic blood pressure) were computed. Path analysis was used to estimate the effect of DHEAS at age 7 on cardiometabolic traits at ages 10 and 13, adjusted for body mass index (BMI) z-score and Tanner stage.

Results

DHEAS at age 7 correlated positively with insulin and HOMA-IR at ages 7 and 10 in both sexes, and at age 13 in girls, but not in boys. In girls, DHEAS levels at age 7 directly influenced HOMA-IR at age 13, controlling for BMI and Tanner stage. In boys, DHEAS at age 7 did not influence HOMA-IR at ages 10 and 13. DHEAS at age 7 did not influence the other cardio-metabolic outcomes analyzed.

Conclusions

DHEAS levels in mid-childhood have a positive longitudinal association with on insulin-resistance that persists, in girls, but not in boys, at least until age 13. No association was found regarding dyslipidemia, hypertension, or low-grade inflammation.

Keywords: adrenarche; cardiovascular risk; dehydroepiandrosterone sulfate; generation XXI; metabolic syndrome
Corresponding author: Rita Santos-Silva, Pediatric Endocrinology Unit, Department of Pediatrics, Centro Hospitalar Universitário de S. João, Porto, Portugal; Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; EPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Unidade de Endocrinologia Pediátrica, Serviço de Pediatria, Centro Hospitalar Universitário de S. João, Porto, Portugal; Departamento de Ginecologia-Obstetrícia e Pediatria, Faculdade de Medicina, Universidade do Porto, Porto, Portugal; and ITR – Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional, Porto, Portugal, Phone: +351964882792, E-mail:

Funding source: European Regional Development Fund (ERDF) through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology (FCT), Portuguese Ministry of Science, Technology and Higher Education

Award Identifier / Grant number: “HIneC: When do health inequalities start? Understanding the impact of childhood social adversity on health trajectories from birth to early adolescence”

Award Identifier / Grant number: POCI-01-0145-FEDER-029567; Reference PTDC/SAU-PUB/29567/2017

Acknowledgments

The authors gratefully acknowledge the families enrolled in Generation XXI for their kindness, all members of the research team for their enthusiasm and perseverance, as well as the participating hospitals and their staff for their help and support.

  1. Research funding: Generation XXI was supported by the European Regional Development Fund (ERDF) through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology (FCT), Portuguese Ministry of Science, Technology and Higher Education under the project “HIneC: When do health inequalities start? Understanding the impact of childhood social adversity on health trajectories from birth to early adolescence” (POCI-01-0145-FEDER-029567; Reference PTDC/SAU-PUB/29567/2017). It is also supported by the Unidade de Investigação em Epidemiologia - Instituto de Saúde Pública da Universidade do Porto (EPIUnit) (UIDB/04750/2020), Administração Regional de Saúde Norte (Regional Department of Ministry of Health) and Fundação Calouste Gulbenkian. This study was also supported by a grant from the Portuguese Society of Paediatrics.

  2. Author contributions: RSS: contributed to the design of the study and the acquisition of data, conducted the analysis and interpretation of data, and drafted the article. MF: contributed to the conception of the study, the interpretation of data and revised the article critically for relevant knowledgeable content. MS: conducted the analysis and interpretation of data and revised the article critically for relevant knowledgeable content. ACS: contributed to the conception of the study and the acquisition of data, participated in the analysis and interpretation of data, and revised the article critically for relevant knowledgeable content. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest. The funding organizations played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Informed consent: Parents, or legal representatives of the children, signed informed consent at the baseline and all the subsequent follow-up evaluations. Children also gave their oral assent.

  5. Ethical approval: All the phases of the study complied with the Ethical Principles for Medical Research Involving Human Subjects expressed in the Declaration of Helsinki. The study was approved by the Universidade do Porto Ethics Committee.

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Received: 2022-11-23
Accepted: 2023-04-17
Published Online: 2023-05-05
Published in Print: 2023-06-27

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Impacts of the COVID-19 pandemic on the diagnosis of idiopathic central precocious puberty in pediatric females in New York City
  4. Genetic and clinical features of patients with intrahepatic cholestasis caused by citrin deficiency
  5. Unique clinical presentations and follow-up outcomes from experience with congenital disorders of glycosylation: PMM2-PGM1-DPAGT1-MPI-POMT2-B3GALNT2-DPM1-SRD5A3-CDG
  6. Executive function, behavioral problems, and insulin resistance in adolescents with obesity
  7. Utility of apolipoprotein ratio in predicting metabolic risk and microvascular complications in Indian children and young adults with type 1 diabetes mellitus
  8. Evaluation of 700 patients referred with a preliminary diagnosis of biotinidase deficiency by the national newborn metabolic screening program: a single-center experience
  9. Adiponectin–leptin ratio as a marker of cardio-metabolic risk in Indian children and youth with type 1 diabetes
  10. Dehydroepiandrosterone sulfate levels at 7 years old and cardio-metabolic factors at 10 and 13 years old – the generation XXI birth cohort
  11. Turner syndrome: results of the first Tunisian study group on Turner syndrome (TuSGOT)
  12. Adolescents who practice physical activity have adequate food choices, regardless of the level of somatic maturation and adiposity
  13. Case Reports
  14. ABCC8-related maturity-onset diabetes of the young: switching from insulin to sulphonylurea therapy: how long do we need for a good metabolic control?
  15. Coexistence of Graves’ disease with acute rheumatic fever treated as thyroid storm in young Thai patient
  16. GM1 gangliosidosis: patients with different phenotypic features and novel mutations
  17. Novel sonic hedgehog gene variant in a patient with hyponatremia, microsomia, and midline defects; phenotype description in association with a variant of unknown significance [c.755_757del p.(Phe252del)] and an approach to salt-wasting in SHH-related adrenal disorders
https://doi.org/10.1515/jpem-2022-0593
Schlagwörter für diesen Artikel
adrenarche; cardiovascular risk; dehydroepiandrosterone sulfate; generation XXI; metabolic syndrome

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Impacts of the COVID-19 pandemic on the diagnosis of idiopathic central precocious puberty in pediatric females in New York City
  4. Genetic and clinical features of patients with intrahepatic cholestasis caused by citrin deficiency
  5. Unique clinical presentations and follow-up outcomes from experience with congenital disorders of glycosylation: PMM2-PGM1-DPAGT1-MPI-POMT2-B3GALNT2-DPM1-SRD5A3-CDG
  6. Executive function, behavioral problems, and insulin resistance in adolescents with obesity
  7. Utility of apolipoprotein ratio in predicting metabolic risk and microvascular complications in Indian children and young adults with type 1 diabetes mellitus
  8. Evaluation of 700 patients referred with a preliminary diagnosis of biotinidase deficiency by the national newborn metabolic screening program: a single-center experience
  9. Adiponectin–leptin ratio as a marker of cardio-metabolic risk in Indian children and youth with type 1 diabetes
  10. Dehydroepiandrosterone sulfate levels at 7 years old and cardio-metabolic factors at 10 and 13 years old – the generation XXI birth cohort
  11. Turner syndrome: results of the first Tunisian study group on Turner syndrome (TuSGOT)
  12. Adolescents who practice physical activity have adequate food choices, regardless of the level of somatic maturation and adiposity
  13. Case Reports
  14. ABCC8-related maturity-onset diabetes of the young: switching from insulin to sulphonylurea therapy: how long do we need for a good metabolic control?
  15. Coexistence of Graves’ disease with acute rheumatic fever treated as thyroid storm in young Thai patient
  16. GM1 gangliosidosis: patients with different phenotypic features and novel mutations
  17. Novel sonic hedgehog gene variant in a patient with hyponatremia, microsomia, and midline defects; phenotype description in association with a variant of unknown significance [c.755_757del p.(Phe252del)] and an approach to salt-wasting in SHH-related adrenal disorders
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