An improvement in the calculation of the efficiency of oxidative phosphorylation and rate of energy dissipation in mitochondria
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Mohazabeh Ghafuri
,
Bahareh Golfar
Abstract
The process of ATP production is one of the most vital processes in living cells which happens with a high efficiency. Thermodynamic evaluation of this process and the factors involved in oxidative phosphorylation can provide a valuable guide for increasing the energy production efficiency in research and industry. Although energy transduction has been studied qualitatively in several researches, there are only few brief reviews based on mathematical models on this subject. In our previous work, we suggested a mathematical model for ATP production based on non-equilibrium thermodynamic principles. In the present study, based on the new discoveries on the respiratory chain of animal mitochondria, Golfar's model has been used to generate improved results for the efficiency of oxidative phosphorylation and the rate of energy loss. The results calculated from the modified coefficients for the proton pumps of the respiratory chain enzymes are closer to the experimental results and validate the model.
© 2014 by De Gruyter
Articles in the same Issue
- Frontmatter
- An improvement in the calculation of the efficiency of oxidative phosphorylation and rate of energy dissipation in mitochondria
- First and second thermodynamic law analyses applied to a solar dish collector
- H. B. Reitlinger and the origins of the efficiency at maximum power formula for heat engines
- Non-equilibrium thermodynamics analysis of transcriptional regulation kinetics
- Study of ethane hydrate formation kinetics using the chemical affinity model with and without presence of surfactants
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Articles in the same Issue
- Frontmatter
- An improvement in the calculation of the efficiency of oxidative phosphorylation and rate of energy dissipation in mitochondria
- First and second thermodynamic law analyses applied to a solar dish collector
- H. B. Reitlinger and the origins of the efficiency at maximum power formula for heat engines
- Non-equilibrium thermodynamics analysis of transcriptional regulation kinetics
- Study of ethane hydrate formation kinetics using the chemical affinity model with and without presence of surfactants
- Derivation of the mechanical and thermodynamic potentials from the generalized BMP model under shear-banding flow
