Cytokines and their role in hyperthermia and heat stroke

Yuval Heled; Chen Fleischmann; Yoram Epstein

doi:10.1515/jbcpp-2012-0040

Article

Cytokines and their role in hyperthermia and heat stroke

Yuval Heled , Chen Fleischmann and Yoram Epstein

Published/Copyright: March 18, 2013

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From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 24 Issue 2

Abstract

Cytokines are intracellular peptides that serve as immune mediators. The levels of both pro- and anti-inflammatory cytokines have been demonstrated to rise in the event of heat stroke in both human and animal models. Different hyperthermic states, including both normal exercise-induced hyperthermia and classical and exertional heat stroke, result in unique characteristic profiles of plasma cytokines. The complexity of the interaction between pro- and anti-inflammatory cytokines is outlined in the vast number of experimental studies and clinical observations reported in the literature. However, there is no unanimous logic in studying the changes in cytokine levels, and therefore, it is difficult to compare the effects seen in the different reports. The strong inflammatory response to heat stroke increases after the cessation of heat stress and is intricately involved both in damage-generating processes and in repair mechanisms that are put into action during the recovery phase. In surviving individuals, this response diminishes in magnitude as time progresses and eventually subsides to allow return-to-normal homeostasis. A greater magnitude of the inflammatory response is often associated with poor prognosis and even fatalities, suggesting an imbalance of the immune system, which causes an unregulated inflammatory response. This review describes the common known processes relating to the predominant cytokines altered in the event of heat injury. The role of cytokines, specifically in the pathophysiology of heat stroke, is elaborated and depicted as part of a biaxial model pertaining to the physiological and cellular/biochemical aspects of heat stroke.

Keywords: exercise; heat stroke; heat wave; hyperthermia; inflammation

Corresponding author: Prof. Yoram Epstein, Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer 52621, Israel, Phone: +972-3-5303564, Fax: +972-3-7377002

Received: 2012-8-19

Accepted: 2013-1-31

Published Online: 2013-03-18

Published in Print: 2013-05-01

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Articles in the same Issue

https://doi.org/10.1515/jbcpp-2012-0040

Keywords for this article

exercise; heat stroke; heat wave; hyperthermia; inflammation