Startseite Preparation and Characterization of Genipin-Crosslinked Chitosan Microspheres for the Sustained Release of Salidroside
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Preparation and Characterization of Genipin-Crosslinked Chitosan Microspheres for the Sustained Release of Salidroside

  • Mei Luo , Hailong Peng , Zhonghua Deng , Zhonghua Yin , Qiang Zhao und Hua Xiong EMAIL logo
Veröffentlicht/Copyright: 14. Mai 2015
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Abstract

Chitosan microspheres (CsMs) that encapsulate salidroside (Sal) were prepared by the emulsion crosslinking method with naturally occurring genipin (Gp) and then examined for their in vitro release. Sal-loaded CsMs (Sal-CsMs) showed nearly spherical and smooth surfaces with internal voids. The particle size of Sal-CsMs ranged within 0.56–5.01 μm, and their encapsulation efficiency and loading capacity were beyond 77.58% and 23.29%, respectively. The stability of Sal improved after entrapment into the CsMs. The release rate of Sal from CsMs was initially rapid, followed by sustained release. The release behavior depended on the pH of the release medium. The main release mechanisms underlying the release procedure were anomalous behavior and Fickian diffusion. These results indicated that CsMs with a novel crosslinker of Gp was a potential carrier system for producing functional foods containing Sal.

Funding statement: Funding: This work was supported by the Planning Subject of “the Twelfth Five–Year–Plan” National Science and Technology for the Rural development of China (No. 2013AA102203–05), the National Natural Science Foundation of China (No. 21266020), the Natural Science Foundation of Jiangxi Province (20142BAB213003), and Jiangxi Department of Education Fund (GJJ13039).

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Supplemental Material

The online version of this article (DOI: 10.1515/ijfe-2014-0314) offers supplementary material, available to authorized users.


Published Online: 2015-5-14
Published in Print: 2015-6-1

©2015 by De Gruyter

Heruntergeladen am 12.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/ijfe-2014-0314/pdf?lang=de
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