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Waist-height ratio highlights detrimental risk for olanzapine associated weight gain earlier than body mass index

  • Ibrahim Mohammed Badamasi ORCID logo EMAIL logo , Abiola Tajudeen , Shakirat D. Owolabi , Margaret I. Ojeahere , Asuku A. Yusuf , Mujittapha U. Sirajo ORCID logo and Mustapha I. Gudaji EMAIL logo
Published/Copyright: October 22, 2024
International Journal of Adolescent Medicine and Health
From the journal International Journal of Adolescent Medicine and Health Volume 36 Issue 6

Abstract

Objective

The objective of the current study was to compare the level of sensitivity of body mass index (BMI) or waist-height ratio (WHtR) in identifying physically determinable adiposity levels that are considered to be landmarks for commencing intervention to prevent more sinister cardio-metabolic risks among schizophrenia patients receiving olanzapine.

Methods

The study was a descriptive crossectional one among patients with schizophrenia recieving olanzapine and healthy volunteers as controls. Key measurement of anthropological parameters were compared between the population.

Results

Our findings revealed significantly higher rates of abnormal body mass index (BMI) (X2=17.06, p=0.000036; OR=4.58, CI=2.16–9.74) and abnormal waist-height ratio (WHtR) (X2=35.57, p=2.46E-9; OR=6.37, CI=3.39–12.00) among the schizophrenia patients compared to the healthy volunteers. Notably, BMI identified 43.3 % of the schizophrenia patients as having concerning weight changes, whereas WHtR identified 64.7 %, indicating that WHtR is a more sensitive measure. This discrepancy means that an additional 21.4 % of schizophrenia patients would benefit from weight management guidance based on WHtR rather than BMI.

Conclusion

Our results underscore the critical importance of WHtR in assessing adiposity among schizophrenia patients treated with olanzapine, highlighting its value as a tool for monitoring and managing cardiometabolic risks in this population.

Keywords: schizophrenia; olanzapine; obesity; body mass index (BMI); waist-height ratio (WHtR)
Corresponding authors: Ibrahim Mohammed Badamasi, Department of Anatomy, Pharmacogenomics and Pharmacometabolomics Unit, Faculty of Basic Medical Sciences, College of Health Sciences, Bayero University Kano, Kano, Nigeria; and Formerly of the Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, E-mail: ; and Mustapha I. Gudaji , Department of Psychiatry, Bayero University Kano, Kano, Nigeria, E-mail:

Funding source: Institution Based Research Fund from Federal University of Health Sciences Azare

Award Identifier / Grant number: 0003

Acknowledgments

As a team, we extend our sincere appreciation to the Federal University of Health Sciences Azare for their generous support through the institution-based research grant. This funding has been instrumental in advancing our research endeavors. We also acknowledge research assistant like: Abdulazeem Muhammad Andujeh, Ibrahim Muhammad Dauda who contributed to data capturing from study participants.

  1. Research ethics: The research protocol was submitted to the research ethics committee of Bayero University for assessment and certification. The committee certified the research with ethics number NHREC/06/12/19/209. The ethics clearance was reviewed by hospital management and permission to conduct research was granted by the psychiatry department of the hospital.

  2. Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: Not used.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: Institution Based research fund for Federal University of Health Sciences Azare.

  7. Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Received: 2024-06-27
Accepted: 2024-10-03
Published Online: 2024-10-22

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Editorial
  4. Review
  5. Investigating various interventions to improve the quality of life of children and adolescents suffering from chronic diseases – a systematic review
  6. Original Articles
  7. A socio-ecological approach to understanding self-regulation among adolescents with developmental challenges and delays
  8. Social, academic, and emotional self-efficacies in adolescent girls and their determinants: a cross sectional study
  9. Psychiatric hospitalizations among adolescents during the pandemic in Italy: a retrospective study
  10. Reliability and validity of the Game Addiction Scale in Malaysian Adolescents
  11. Waist-height ratio highlights detrimental risk for olanzapine associated weight gain earlier than body mass index
  12. A cross-sectional study of satisfaction with life among 1st year students and doctors of a teaching hospital of the national capital region
  13. Menstrual disorder and its treatment seeking among adolescent girls in India: evidence from nationwide survey
  14. Reviewer Acknowledgment
  15. Reviewer acknowledgment
https://doi.org/10.1515/ijamh-2024-0099
Keywords for this article
schizophrenia; olanzapine; obesity; body mass index (BMI); waist-height ratio (WHtR)

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Editorial
  4. Review
  5. Investigating various interventions to improve the quality of life of children and adolescents suffering from chronic diseases – a systematic review
  6. Original Articles
  7. A socio-ecological approach to understanding self-regulation among adolescents with developmental challenges and delays
  8. Social, academic, and emotional self-efficacies in adolescent girls and their determinants: a cross sectional study
  9. Psychiatric hospitalizations among adolescents during the pandemic in Italy: a retrospective study
  10. Reliability and validity of the Game Addiction Scale in Malaysian Adolescents
  11. Waist-height ratio highlights detrimental risk for olanzapine associated weight gain earlier than body mass index
  12. A cross-sectional study of satisfaction with life among 1st year students and doctors of a teaching hospital of the national capital region
  13. Menstrual disorder and its treatment seeking among adolescent girls in India: evidence from nationwide survey
  14. Reviewer Acknowledgment
  15. Reviewer acknowledgment
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