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HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8

  • Jieying Wu , Ling Zhang , Yashu Feng , Bijay Khadka , Zhigang Fang and Jiajun Liu ORCID logo EMAIL logo
Published/Copyright: December 17, 2020
Biological Chemistry
From the journal Biological Chemistry Volume 402 Issue 4

Abstract

The chemoresistance is one of the major challenges for acute myeloid leukemia (AML) treatment. We found that the expression of histone deacetylase 8 (HDAC8) was increased in daunorubicin (DNR) resistant AML cells, while targeted inhibition of HDAC8 by its specific siRNA or inhibitor can restore sensitivity of DNR treatment . Further, targeted inhibition of HDAC8 can suppress expression of interleukin 6 (IL-6) and IL-8. While recombinant IL-6 (rIL-6) and rIL-8 can reverse si-HDAC8-resored DNR sensitivity of AML cells. Mechanistical study revealed that HDAC8 increased the expression of p65, one of key components of NF-κB complex, to promote the expression of IL-6 and IL-8. It might be due to that HDAC8 can directly bind with the promoter of p65 to increase its transcription and expression. Collectively, our data suggested that HDAC8 promotes DNR resistance of human AML cells via regulation of IL-6 and IL-8.

Keywords: AML; HDAC8; IL-6; IL-8; p65; resistance
Corresponding author: Jiajun Liu, Department of Hematology and Hematology, Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Avenue, Guangzhou 510630, P. R. China, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflict of interest.

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Received: 2020-05-24
Accepted: 2020-11-30
Published Online: 2020-12-17
Published in Print: 2021-03-26

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

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  2. Minireview
  3. Regulation of RNA stability at the 3′ end
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  5. Protein Structure and Function
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  8. Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL)
  9. Molecular Medicine
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  11. Cell Biology and Signaling
  12. HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8
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  16. Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria
  17. Retraction Note
  18. Retraction note to: LncRNA MEG3 inhibits HMEC-1 cells growth, migration and tube formation via sponging miR-147
https://doi.org/10.1515/hsz-2020-0196
Keywords for this article
AML; HDAC8; IL-6; IL-8; p65; resistance

Articles in the same Issue

  1. Frontmatter
  2. Minireview
  3. Regulation of RNA stability at the 3′ end
  4. Research Articles/Short Communications
  5. Protein Structure and Function
  6. Phage-display reveals interaction of lipocalin allergen Can f 1 with a peptide resembling the antigen binding region of a human γδT-cell receptor
  7. Membranes, Lipids, Glycobiology
  8. Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL)
  9. Molecular Medicine
  10. Dihydroartemisinin ameliorates balloon injury-induced neointimal formation through suppressing autophagy in vascular smooth muscle cells
  11. Cell Biology and Signaling
  12. HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8
  13. Hsa-miR-186-5p regulates TGFβ signaling pathway through expression suppression of SMAD6 and SMAD7 genes in colorectal cancer
  14. Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity
  15. Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation
  16. Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria
  17. Retraction Note
  18. Retraction note to: LncRNA MEG3 inhibits HMEC-1 cells growth, migration and tube formation via sponging miR-147
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