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HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8

  • Zhaohui Tang , Sijuan Ding EMAIL logo , Honglin Huang , Pengfei Luo , Bohua Qing , Siyuan Zhang and Ruoting Tang
Published/Copyright: August 5, 2017
Biological Chemistry
From the journal Biological Chemistry Volume 398 Issue 12

Abstract

Targeted inhibition of histone deacetylase (HDAC) is one of the potent anticancer therapy approaches. Our data showed that mRNA and protein levels of HDAC1 in breast cancer cells were greater than that in normal fibroblast 3T3 cells and normal epithelial breast MCF10A cells. The mRNA levels of HDAC1 in 75% of breast cancer tissues (18/24) were greater than that in their corresponding adjacent normal tissues. Knockdown of HDAC1 by specific siRNAs can suppress the proliferation and migration of breast cancer cells and inhibit the expression of interleukin-8 (IL-8), while not IL-6. While recombinant IL-8 (rIL-8) can attenuate the suppression effects of si-HDAC1 on the proliferation and migration of breast cancer cells. HDAC1 can positively regulate the transcription and promoter activities of IL-8. While NF-κB and MAPK, two important signals responsible for the transcription of IL-8, did not mediate HDAC1 regulated IL-8 expression. The expression and nuclear translocation of Snail were increased in HDAC1 over expressed breast cancer cells. Targeted inhibition of Snail can attenuate HDAC1 over expression induced cell proliferation and migration. Collectively, our data showed that HDAC1 can trigger the proliferation and migration of breast cancer cells via activation of Snail/IL-8 signals.

Keywords: breast cancer; HDAC1; IL-8; migration; proliferation; Snail

  1. Conflict of interest statement: The authors declare no conflict of interest.

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Received: 2017-5-4
Accepted: 2017-8-1
Published Online: 2017-8-5
Published in Print: 2017-11-27

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Regulation of protein function by S-nitrosation and S-glutathionylation: processes and targets in cardiovascular pathophysiology
  4. Cystine knot growth factors and their functionally versatile proregions
  5. Kallistatin: double-edged role in angiogenesis, apoptosis and oxidative stress
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  11. Cell Biology and Signaling
  12. The molecular mechanisms involved in lectin-induced human platelet aggregation
  13. HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8
  14. Heat shock protein 47 effects on hepatic stellate cell-associated receptors in hepatic fibrosis of Schistosoma japonicum-infected mice
https://doi.org/10.1515/hsz-2017-0155
Keywords for this article
breast cancer; HDAC1; IL-8; migration; proliferation; Snail

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Regulation of protein function by S-nitrosation and S-glutathionylation: processes and targets in cardiovascular pathophysiology
  4. Cystine knot growth factors and their functionally versatile proregions
  5. Kallistatin: double-edged role in angiogenesis, apoptosis and oxidative stress
  6. Minireview
  7. The sphingomyelin synthase family: proteins, diseases, and inhibitors
  8. Research Articles/Short Communications
  9. Genes and Nucleic Acids
  10. Comparison of cytochrome P450 expression in four different human osteoblast models
  11. Cell Biology and Signaling
  12. The molecular mechanisms involved in lectin-induced human platelet aggregation
  13. HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8
  14. Heat shock protein 47 effects on hepatic stellate cell-associated receptors in hepatic fibrosis of Schistosoma japonicum-infected mice
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