Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity

References

Aksoy, S., Szumlanski, C.L., and Weinshilboum, R.M. (1994). Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J. Biol. Chem. 269, 14835–14840.10.1016/S0021-9258(17)36700-5Suche in Google Scholar

Audrito, V., Vaisitti, T., Rossi, D., Gottardi, D., D’Arena, G., Laurenti, L., Gaidano, G., Malavasi, F., and Deaglio, S. (2011). Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. Cancer Res. 71, 4473–4483.10.1158/0008-5472.CAN-10-4452Suche in Google Scholar

Balducci, E., Emanuelli, M., Raffaelli, N., Ruggieri, S., Amici, A., Magni, G., Orsomando, G., Polzonetti, V., and Natalini, P. (1995). Assay methods for nicotinamide mononucleotide adenylyltransferase of wide applicability. Anal. Biochem. 228, 64–68.10.1006/abio.1995.1315Suche in Google Scholar

Bartuś, M., Łomnicka, M., Kostogrys, R.B., Kaźmierczak, P., Watała, C., Słominska, E.M., Smoleński, R.T., Pisulewski, P.M., Adamus, J., Gebicki, J., et al. (2008). 1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats. Pharmacol. Rep. 60, 127–138.Suche in Google Scholar

Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248–254.10.1016/0003-2697(76)90527-3Suche in Google Scholar

Brzozowski, T., Konturek, P.C., Chlopicki, S., Sliwowski, Z., Pawlik, M., Ptak-Belowska, A., Kwiecien, S., Drozdowicz, D., Pajdo, R., Slonimska, E., et al. (2008). Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves. J. Pharmacol. Exp. Ther. 326, 105–116.10.1124/jpet.108.136457Suche in Google Scholar PubMed

Chlopicki, S., Swies, J., Mogielnicki, A., Buczko, W., Bartus, M., Lomnicka, M., Adamus, J., and Gebicki, J. (2007). 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. Br. J. Pharmacol. 152, 230–239.10.1038/sj.bjp.0707383Suche in Google Scholar PubMed PubMed Central

D’Andrea, F.P., Safwat, A., Kassem, M., Gautier, L., Overgaard, J., and Horsman, M.R. (2011). Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. Radiother. Oncol. 99, 373–378.10.1016/j.radonc.2011.05.086Suche in Google Scholar PubMed

Debigaré, R., Maltais, F., Côté, C.H., Michaud, A., Caron, M.A., Mofarrahi, M., Leblanc, P., and Hussain, S.N. (2008). Profiling of mRNA expression in quadriceps of patients with COPD and muscle wasting. COPD. 5, 75–84.10.1080/15412550801940457Suche in Google Scholar PubMed

Emanuelli, M., Santarelli, A., Sartini, D., Ciavarella, D., Rossi, V., Pozzi, V., Rubini, C., and Lo Muzio, L. (2010). Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma. Histol. Histopathol. 25, 15–20.Suche in Google Scholar

Kim, H.C., Mofarrahi, M., Vassilakopoulos, T., Maltais, F., Sigala, I., Debigare, R., Bellenis, I., and Hussain, S.N. (2010). Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 181, 797–805.10.1164/rccm.200906-0936OCSuche in Google Scholar PubMed

Lim, B.H., Cho, B.I., Kim, Y.N., Kim, J.W., Park, S.T., and Lee, C.W. (2006). Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification. Exp. Mol. Med. 38, 455–465.10.1038/emm.2006.54Suche in Google Scholar PubMed

Liu, Y., He, S., Ding, Y., Huang, J., Zhang, Y., and Chen, L. (2014). The efficacy and safety of thalidomide-based therapy in patients with advanced non-small cell lung cancer: a meta-analysis. Contemp. Oncol. 18, 39–47.10.5114/wo.2014.40782Suche in Google Scholar

Markert, J.M., Fuller, C.M., Gillespie, G.Y., Bubien, J.K., McLean, L.A., Hong, R.L., Lee, K., Gullans, S.R., Mapstone, T.B., and Benos, D.J. (2001). Differential gene expression profiling in human brain tumors. Physiol. Genomics. 5, 21–33.10.1152/physiolgenomics.2001.5.1.21Suche in Google Scholar

Mateuszuk, Ł., Khomich, T.I., Słomińska, E., Gajda, M., Wójcik, L., łomnicka, M., Gwóźdź, P., and Chłopicki, S. (2009). Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis. Pharmacol. Rep. 61, 76–85.10.1016/S1734-1140(09)70009-XSuche in Google Scholar

Milani, Z.H., Ramsden, D.B., and Parsons, R.B. (2013). Neuroprotective effects of nicotinamide N-methyltransferase and its metabolite 1-methylnicotinamide. J. Biochem. Mol. Toxicol. 27, 451–456.10.1002/jbt.21508Suche in Google Scholar

Niklinski, J. and Hirsch, F.R. (2002). Molecular approaches to lung cancer evaluation. Lung Cancer. 38, S9–S17.10.1016/S0169-5002(02)00260-XSuche in Google Scholar

Parsons, R.B., Smith, M.L., Williams, A.C., Waring, R.H., and Ramsden, D.B. (2002). Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain. J. Neuropathol. Exp. Neurol. 61, 111–124.10.1093/jnen/61.2.111Suche in Google Scholar PubMed

Parsons, R.B., Aravindan, S., Kadampeswaran, A., Evans, E.A., Sandhu, K.K., Levy, E.R., Thomas, M.G., Austen, B.M., and Ramsden, D.B. (2011). The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors. Biochem. J. 436, 145–155.10.1042/BJ20101685Suche in Google Scholar PubMed

Pei, B.X., Sun, B.S., Zhang, Z.F., Wang, A.L., and Ren, P. (2014). Interstitial tumor-associated macrophages combined with tumor-derived colony-stimulating factor-1 and interleukin-6, a novel prognostic biomarker in non-small cell lung cancer. J. Thorac. Cardiovasc. Surg. In press.10.1016/j.jtcvs.2014.05.003Suche in Google Scholar PubMed

Peng, Y., Sartini, D., Pozzi, V., Wilk, D., Emanuelli, M., and Yee, V.C. (2011). Structural basis of substrate recognition in human nicotinamide N-methyltransferase. Biochemistry. 50, 7800–7808.10.1021/bi2007614Suche in Google Scholar PubMed PubMed Central

Pozzi, V., Mazzotta, M., Lo Muzio, L., Sartini, D., Santarelli, A., Renzi, E., Rocchetti, R., Tomasetti, M., Ciavarella, D., and Emanuelli, M. (2011). Inhibiting proliferation in KB cancer cells by RNA interference-mediated knockdown of nicotinamide N-methyltransferase expression. Int. J. Immunopathol. Pharmacol. 24, 69–77.10.1177/039463201102400109Suche in Google Scholar PubMed

Pozzi, V., Sartini, D., Morganti, S., Giuliante, R., Di Ruscio, G., Santarelli, A., Rocchetti, R., Rubini, C., Tomasetti, M., Giannatempo, G., et al. (2013). RNA-mediated gene silencing of nicotinamide N-methyltransferase is associated with decreased tumorigenicity in human oral carcinoma cells. PLoS One. 8, e71272.10.1371/journal.pone.0071272Suche in Google Scholar

Roessler, M., Rollinger, W., Palme, S., Hagmann, M.L., Berndt, P., Engel, A.M., Schneidinger, B., Pfeffer, M., Andres, H., Karl, J., et al. (2005). Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin. Cancer Res. 11, 6550–6557.10.1158/1078-0432.CCR-05-0983Suche in Google Scholar

Rogers, C.D., Fukushima, N., Sato, N., Shi, C., Prasad, N., Hustinx, S.R., Matsubayashi, H., Canto, M., Eshleman, J.R., Hruban, R.H., et al. (2006). Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer. Biol. Ther. 5, 1383–1389.10.4161/cbt.5.10.3323Suche in Google Scholar

Sartini, D., Muzzonigro, G., Milanese, G., Pierella, F., Rossi, V., and Emanuelli, M. (2006). Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma. J. Urol. 176, 2248–2254.10.1016/j.juro.2006.07.046Suche in Google Scholar

Sartini, D., Santarelli, A., Rossi, V., Goteri, G., Rubini, C., Ciavarella, D., Lo Muzio, L., and Emanuelli, M. (2007). Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol. Med. 13, 415–421.10.2119/2007-00035.SartiniSuche in Google Scholar

Sartini, D., Pozzi, V., Renzi, E., Morganti, S., Rocchetti, R., Rubini, C., Santarelli, A., Lo Muzio, L., and Emanuelli, M. (2012). Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease. Biol. Chem. 393, 505–11.10.1515/hsz-2012-0112Suche in Google Scholar

Sartini, D., Muzzonigro, G., Milanese, G., Pozzi, V., Vici, A., Morganti, S., Rossi, V., Mazzucchelli, R., Montironi, R., and Emanuelli, M. (2013a). Upregulation of tissue and urinary nicotinamide N-methyltransferase in bladder cancer: potential for the development of a urine-based diagnostic test. Cell Biochem. Biophys. 65, 473–483.10.1007/s12013-012-9451-1Suche in Google Scholar

Sartini, D., Morganti, S., Guidi, E., Rubini, C., Zizzi, A., Giuliante, R., Pozzi, V., and Emanuelli, M. (2013b). Nicotinamide N-methyltransferase in non-small cell lung cancer: promising results for targeted anti-cancer therapy. Cell Biochem. Biophys. 67, 865–873.10.1007/s12013-013-9574-zSuche in Google Scholar

Sternak, M., Khomich, T.I., Jakubowski, A., Szafarz, M., Szczepański, W., Białas, M., Stojak, M., Szymura-Oleksiak, J., and Chłopicki, S. (2010). Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse. Pharmacol. Rep. 62, 483–493.10.1016/S1734-1140(10)70304-2Suche in Google Scholar

Sun, S., Schiller, J.H., Spinola, M., and Minna, J.D. (2007). New molecularly targeted therapies for lung cancer. J. Clin. Invest. 117, 2740–2750.10.1172/JCI31809Suche in Google Scholar PubMed PubMed Central

Tang, S.W., Yang, T.C., Lin, W.C., Chang, W.H., Wang, C.C., Lai, M.K., and Lin, J.Y. (2011). Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. Carcinogenesis. 32, 138–145.10.1093/carcin/bgq225Suche in Google Scholar PubMed

Ulanovskaya O.A., Zuhl A.M., and Cravatt B.F. (2013). NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat. Chem. Biol. 9, 300–306.10.1038/nchembio.1204Suche in Google Scholar PubMed PubMed Central

Wu, Y., Siadaty, M.S., Berens, M.E., Hampton, G.M., and Theodorescu, D. (2008). Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene. 27, 6679–6689.10.1038/onc.2008.264Suche in Google Scholar PubMed PubMed Central

Xu, J., Moatamed, F., Caldwell, J.S., Walker, J.R., Kraiem, Z., Taki, K., Brent, G.A., and Hershman, J.M. (2003). Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J. Clin. Endocrinol. Metab. 88, 4990–4996.10.1210/jc.2002-021843Suche in Google Scholar PubMed

Zhang, J. (2003). Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked? Bioessays. 25, 808–814.Suche in Google Scholar

Zhang, J., Wang, Y., Li, G., Yu, H., and Xie, X. (2014a). Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway. PLoS One. 9, e89202.10.1371/journal.pone.0089202Suche in Google Scholar PubMed PubMed Central

Zhang, E.B., Yin, D.D., Sun, M., Kong, R., Liu, X.H., You, L.H., Han, L., Xia, R., Wang, K.M., Yang, J.S., et al. (2014b). P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression. Cell Death Dis. 22, e1243.10.1038/cddis.2014.201Suche in Google Scholar PubMed PubMed Central

Zhao, D.P., Yang, C.L., Zhou, X., Ding, J.A., and Jiang, G.N. (2014). Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies. Mol. Genet. Genomics. In press.10.1007/s00438-014-0868-7Suche in Google Scholar PubMed