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Triplet repeats in transcripts: structural insights into RNA toxicity

  • Paulina Galka-Marciniak

    Paulina Galka-Marciniak graduated in medical biotechnology in 2010 at the Poznan University of Medical Sciences, Poland. She is currently working on her PhD investigating the genetic approaches to RNAi-based experimental therapy of Triplet Repeat Expansion Diseases, the nonspecific immunological side effects triggered by RNAi and microRNA reagents and the mechanisms of microRNA biogenesis.

    , Martyna O. Urbanek

    Martyna Urbanek is a MSc student in medical biotechnology at Poznan University of Medical Science and BCS student in algorithmics and programming engineering at Adam Mickiewicz University. Her research interests span nonspecific immunological effects of RNA interference reagent, RNA visualization in live cells and broadly defined bioinformatics including microarray analysis.

    and Wlodzimierz J. Krzyzosiak

    Professor Wlodzimierz J. Krzyzosiak is Head of Laboratory of Molecular Biomedicine at the Institute of Bioorganic Chemistry, Polish Academy of Sciences in Poznan, Poland. He received his PhD degree from Adam Mickiewicz University in Poznan, and held fellowships at prestigious research centers in the UK, France, USA and Japan. Professor Krzyzosiak has a long-lasting interest in the biochemistry of RNA, and his research achievements include developing a method of RNA structure probing by metal ion-induced cleavages. He also has a long research record in studying the role of RNA repeats in molecular pathology of triplet repeat expansion diseases.

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Published/Copyright: October 11, 2012

Received: 2012-5-31
Accepted: 2012-7-6
Published Online: 2012-10-11
Published in Print: 2012-11-01

©2012 by Walter de Gruyter Berlin Boston

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