The study of ischemia modified albumin as an early biomarker of epilepsy in adolescent population: a cross-sectional study
-
Priyanka Asia
,
Seema Garg
Abstract
Objectives
Epilepsy is one of the most common neurological disorders, diagnosis of which is challenging as many unrelated conditions may mimic seizure. Epilepsy impairs the quality of life of patients due to associated physical and psychological trauma. Epileptic patients are also at increased risk of premature death due to autonomic disturbance and fatal accidents. The aim of the present research work was to study ischemia modified albumin (IMA) as an early biomarker of epilepsy in the adolescent population.
Methods
Twenty-five diagnosed cases of epilepsy and 25 healthy volunteers as control of adolescent group were recruited as study subjects. The study subjects were age and sex matched. Clinical evaluation, routine biochemical parameters and IMA estimation were carried out. Serum IMA was measured by spectrophotometric method.
Results
The mean serum IMA levels were significantly raised in epileptic patients (0.69 ± 0.1 absorbance units [ABSU]) as compared to the healthy control group (0.52 ± 0.24 ABSU) (p=0.004). ROC curve of IMA predicted that at cut off of 0.59 ABSU, the IMA has 96% sensitivity and 52% specificity for diagnosing epilepsy.
Conclusions
IMA may be used as a biomarker for early diagnosis of epilepsy as well as to differentiate epileptic seizure from various non epileptic disorders in the adolescent population.
Funding source: Indian Council of Medical Research
Award Identifier / Grant number: STS ICMR Project 2019- 20
Acknowledgments
We are very thankful to Dr. Y. V. Bansod from Department of Medicine and Dr. Dipty Jain from Department of Pediatrics, GMC, Nagpur, MH for their contribution in the recruitment of the study population.
Research funding: Funded by the Indian Council of Medical Research (STS ICMR Project 2019–20).
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Conflict of interest: Authors state no conflict of interest.
Informed consent: Informed written consent was taken from the patients/parents/guardian.
Ethical approval: The study was conducted in accordance with the Declaration of Helsinki and approved by Institutional Ethical Committee of AIIMS, Nagpur, MH.
References
1. Stafstrom, CE, Carmant, L. Seizures and epilepsy: an overview for neuroscientists. Cold Spring Harbor Perspect Med 2015:5:022426. https://doi.org/10.1101/cshperspect.a022426.Search in Google Scholar
2. Meyer, AC, Dua, T, Ma, J, Saxena, S, Birbeck, G. Global disparities in the epilepsy treatment gap: a systematic review. Bull World Health Organ 2010;88:260–6. https://doi.org/10.2471/blt.09.064147.Search in Google Scholar
3. Amudhan, S, Gururaj, G, Satishchandra, P. Epilepsy in India I: epidemiology and public health. Ann Indian Acad Neurol 2015;18:263. https://doi.org/10.4103/0972-2327.160093.Search in Google Scholar
4. Santhosh, NS, Sinha, S, Satishchandra, P. Epilepsy: Indian perspective. Ann Indian Acad Neurol 2014;17(Suppl 1):S3. https://doi.org/10.4103/0972-2327.128643.Search in Google Scholar
5. Shin, HW, Jewells, V, Hadar, E, Fisher, T, Hinn, A. Review of epilepsy-etiology, diagnostic evaluation and treatment. Int J Neurorehabilitation 2014;1:2376–0281.Search in Google Scholar
6. Bhalla, D, Godet, B, Druet-Cabanac, M, Preux, PM. Etiologies of epilepsy: a comprehensive review. Exp Rev Neurother 2011;11:861–76. https://doi.org/10.1586/ern.11.51.Search in Google Scholar
7. Yin, YH, Ahmad, N, Makmor-Bakry, M. Pathogenesis of epilepsy: challenges in animal models. Iran J Basic Med Sci 2013;16:1119.Search in Google Scholar
8. Gaze, DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug Metab Pharmacokinet 2009;24:333–41. https://doi.org/10.2133/dmpk.24.333.Search in Google Scholar
9. Onis, MD, Onyango, AW, Borghi, E, Siyam, A, Nishida, C, Siekmann, J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 2007;85:660–7. https://doi.org/10.2471/blt.07.043497.Search in Google Scholar
10. Kamasak, T, Turedi, S, Serin, HM, Mentese, A, Gündüz, A, Alver, A, et al.. Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures? Turk J Med Sci 2017;47:282–6.10.3906/sag-1504-105Search in Google Scholar
11. Bar–Or, D, Lau, E, Winkler, JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia—a preliminary report. J Emerg Med 2000;19:311–5.10.1016/S0736-4679(00)00255-9Search in Google Scholar
12. Uzel, M, Oray, NC, Bayram, B, Kume, T, Girgin, MC, Doylan, O, et al.. Novel biochemical marker for differential diagnosis of seizure: ischemia-modified albumin. Am J Emerg Med 2014;32:962–5. https://doi.org/10.1016/j.ajem.2014.05.003.Search in Google Scholar PubMed
13. Kobylarek, D, Iwanowski, P, Lewandowska, Z, Limphaibool, N, Szafranek, S, Labrzycka, A, et al.. Advances in the potential biomarkers of epilepsy. Front Neurol 2019:10.10.3389/fneur.2019.00685Search in Google Scholar
14. Ristić, AJ, Savić, D, Sokić, D, Bogdanović Pristov, J, Nestorov, J, Baščarević, V, et al.. Hippocampal antioxidative system in mesial temporal lobe epilepsy. Epilepsia 2015;56:789–99.10.1111/epi.12981Search in Google Scholar
15. Gaze, DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug Metabol Pharmacokine 2009;24:333–41. https://doi.org/10.2133/dmpk.24.333.Search in Google Scholar
16. Bar–Or, D, Lau, E, Winkler, JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia—a preliminary report 1. J Emerg Med 2000;19:311–5.10.1016/S0736-4679(00)00255-9Search in Google Scholar
17. Abboud, H, Labreuche, J, Meseguer, E, Lavallee, PC, Simon, O, Olivot, JM, et al.. Ischemia-modified albumin in acute stroke. Cerebrovasc Dis 2007;23:216–20. https://doi.org/10.1159/000097644.Search in Google Scholar PubMed
18. Kocaoglu, C, Caksen, H, Atabek, ME, Kurku, H, Arslan, S. Serum ischemia-modified albumin levels in children with epileptic seizures. Pediatr Emerg Care 2014.10.1097/PEC.0000000000000145Search in Google Scholar PubMed
19. Inci, A, Gencpinar, P, Orhan, D, Uzun, G, Ozdem, S, Samur, AA, et al.. Ischemia-modified albumin levels in children having seizure. Brain and Development 2013;35:849. https://doi.org/10.1016/j.braindev.2012.11.004.Search in Google Scholar PubMed
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Special Section: "Progestogen-only pill and its therapeutic indications and effects"; Guest Editors: Adolf E- Schindler and René Druckmann
- Original Articles
- Peritoneal fluid biomarkers in patients with endometriosis: a cross-sectional study
- Safety, influence on the endometrium, sonographic changes and bleeding profile after 13 cycles with the new drospirenone only pill (DOP) for contraception
- Review Articles
- A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion -
- Progestogens in luteal support
- Mini Review
- Progestogen-only pills: which progestogen would be ideal
- Regular Issue
- Original Articles
- Outcomes of surgical and/or medical treatment in patients with prolactinomas during long-term follow-up: a retrospective single-centre study
- PPARGC1A promoter DNA-methylation level and glucose metabolism in Ecuadorian women with Turner syndrome
- Allium jesdianum hydro alcoholic extract ameliorates diabetic nephropathy by suppressing connective tissue growth factor (CTGF) and receptor for advanced glycation endproducts (RAGE) gene expression in diabetic rats with streptozotocin
- Changes in serum levels of Apo AIV in patients with newly diagnosed hyperthyroidism and hypothyroidism: a preliminary study
- The study of ischemia modified albumin as an early biomarker of epilepsy in adolescent population: a cross-sectional study
- Short Communications
- The effect of water-based rhythmic exercise training on glucose homeostasis and thyroid hormones in postmenopausal women with metabolic syndrome
- Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome
- Case Report
- A rare association of two endocrine tumours: non-functional oncocytic adrenocortical carcinoma and Papillary thyroid carcinoma
- Mini Review
- Vitamin D and new insights into pathophysiology of type 2 diabetes
- Review Articles
- Sex steroids-induced neurogenesis in adult brain: a better look at mechanisms and mediators
- Genetic variants and risk of thyroid cancer among Iranian patients
Articles in the same Issue
- Frontmatter
- Special Section: "Progestogen-only pill and its therapeutic indications and effects"; Guest Editors: Adolf E- Schindler and René Druckmann
- Original Articles
- Peritoneal fluid biomarkers in patients with endometriosis: a cross-sectional study
- Safety, influence on the endometrium, sonographic changes and bleeding profile after 13 cycles with the new drospirenone only pill (DOP) for contraception
- Review Articles
- A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion -
- Progestogens in luteal support
- Mini Review
- Progestogen-only pills: which progestogen would be ideal
- Regular Issue
- Original Articles
- Outcomes of surgical and/or medical treatment in patients with prolactinomas during long-term follow-up: a retrospective single-centre study
- PPARGC1A promoter DNA-methylation level and glucose metabolism in Ecuadorian women with Turner syndrome
- Allium jesdianum hydro alcoholic extract ameliorates diabetic nephropathy by suppressing connective tissue growth factor (CTGF) and receptor for advanced glycation endproducts (RAGE) gene expression in diabetic rats with streptozotocin
- Changes in serum levels of Apo AIV in patients with newly diagnosed hyperthyroidism and hypothyroidism: a preliminary study
- The study of ischemia modified albumin as an early biomarker of epilepsy in adolescent population: a cross-sectional study
- Short Communications
- The effect of water-based rhythmic exercise training on glucose homeostasis and thyroid hormones in postmenopausal women with metabolic syndrome
- Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome
- Case Report
- A rare association of two endocrine tumours: non-functional oncocytic adrenocortical carcinoma and Papillary thyroid carcinoma
- Mini Review
- Vitamin D and new insights into pathophysiology of type 2 diabetes
- Review Articles
- Sex steroids-induced neurogenesis in adult brain: a better look at mechanisms and mediators
- Genetic variants and risk of thyroid cancer among Iranian patients
