Predicting of factors associated with valsartan response among hypertensive patients attending the Jordan University Hospital
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Shahd Khalil
Abstract
Objectives
There is an inter-individual in the valsartan response among hypertensive patients. However, clinical factors associated with this variation in the response is still not fully understood. The major purpose of this study is to predict the factors associated with valsartan response and their influence on decreasing blood pressure among patients.
Methods
This study is a cross-sectional observational study. It included 91 hypertensive patients on valsartan treatment, selected through simple random sampling from the Jordan University Hospital. The clinical data was collected through documented medical records in the hospital’s computerized system. The data was analyzed using the chi-square test to compare frequencies and categories.
Results
Patients were divided into systolic and diastolic responders. No statistical significance was found between systolic response to valsartan’s and gender, smoking, age, BMI, lipid profile and HbA1c status. Diastolic responders had a positive significance of p-value = 0.006 with BMI categories, however there was no significance with any other factor.
Conclusions
There was a better diastolic response to valsartan among hypertensive patients with lower BMI levels. BMI can be considered as a factor to personalize the therapy among patients on valsartan. However, further clinical studies with larger sample size are needed to confirm these data.
Acknowledgments
The authors would like to thank Al-Balqa Applied University for supporting this research.
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Research ethics: Ethical clearance for this study was guaranteed by the Institutional Review Board of the Jordan University Hospital and the Balqa Applied University Faculty of Medicine.
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Informed consent: Informed consent was obtained from each volunteer in this study.
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Author contributions: Shahd Khalil, Aseel Quran, Leen Thalji, Malk Al-Adamat, Lina Sabha, Joud Khraisat, Abdel rahman Al Na’ami and Hatem Al-Jazzazi collected the clinical data, did the statistical analysis and wrote the manuscript. Hussein Alhawari obtained IRB from the university of Jordan Hospital and supervised the clinical work. Yazun Jarrar supervised this research and revised the manuscript. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Data are available with the corresponding author upon request.
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- Frontmatter
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- Predicting of factors associated with valsartan response among hypertensive patients attending the Jordan University Hospital
