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Application of vibrational spectroscopy and nuclear magnetic resonance methods for drugs pharmacokinetics research

  • Vladimir V. Rafalskiy , Andrey Yu. Zyubin , Ekaterina M. Moiseeva , Galina S. Kupriyanova , Ivan G. Mershiev , Nadezhda O. Kryukova , Igor I. Kon , Ilya G. Samusev , Yana D. Belousova and Svetlana A. Doktorova EMAIL logo
Published/Copyright: September 28, 2022
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Drug Metabolism and Personalized Therapy
From the journal Drug Metabolism and Personalized Therapy Volume 38 Issue 1

Abstract

Objectives

The development of new methods for determining the concentration of drugs is an actual topic today. The article contains a detailed review on vibrational spectroscopy and nuclear magnetic resonance methods using for pharmacokinetic research. This study is devoted to the possibility of using vibrational spectroscopy and 1H nuclear magnetic resonance spectroscopy to determine the concentration of drugs and the use of these groups of techniques for therapeutic drug monitoring.

Content

The study was conducted by using scientific libraries (Scopus, Web of Science Core Collection, Medline, GoogleScholar, eLIBRARY, PubMed) and reference literature. A search was conducted for the period from 2011 to 2021 in Russian and English, by combinations of words: 1H nuclear magnetic resonance (1H NMR), vibrational spectroscopy, Surface-Enhanced Raman spectroscopy, drug concentration, therapeutic drug monitoring. These methods have a number of advantages and are devoid of some of the disadvantages of classical therapeutic drug monitoring (TDM) methods – high performance liquid chromatography and mass spectrometry. This review considers the possibility of using the methods of surface-enhanced Raman scattering (SERS) and 1H NMR-spectroscopy to assess the concentration of drugs in various biological media (blood, urine), as well as to study intracellular metabolism and the metabolism of ophthalmic drugs. 1Н NMR-spectroscopy can be chosen as a TDM method, since it allows analyzing the structure and identifying metabolites of various drugs. 1Н NMR-based metabolomics can provide information on the side effects of drugs, predict response to treatment, and provide key information on the mechanisms of action of known and new drug compounds.

Summary and outlook

SERS and 1Н NMR-spectroscopy have great potential for further study and the possibility of introducing them into clinical practice, including for evaluating the efficacy and safety of drugs.

Keywords: pharmacokinetics; pharmacometabolomics; quantitative NMR analysis; Raman spectroscopy; therapeutic drug monitoring
Corresponding author: Svetlana A. Doktorova, REC “Fundamental and Applied Photonics, Nanophotonics”, Kaliningrad, Russia; and Immanuel Kant Baltic Federal University Institute of Medicine – Clinical Trial Center of IKBFU, A. Nevskogo st, 14, Kaliningrad 236016, Russia, Phone: +79622577480, E-mail:

  1. Research funding: Part of the work devoted to the use of Raman scattering and SERS to determine the concentration of drugs was supported by the Russian Science Foundation grant No. 19-15-00132. Part of the work devoted to the application of the 1H NMR method for determining the concentration of drugs was supported by a grant from the Russian Foundation for Basic Research and the Government of the Kaliningrad Region, project No. 19-415-390001.

  2. Author contributions: E.M. Moiseeva – writing the section “Introduction”, compiling sections: “Materials and methods”, “Using Raman scattering and giant Raman scattering to determine the concentration of drugs”, “Application of the 1H NMR method to determine the concentration of drugs”, “Conclusion”, compiling a bibliographic list. A.Yu. Zyubin – compiling sections: “The use of Raman scattering of light and giant Raman scattering of light to determine the concentration of drugs”, “Conclusion”, compiling a bibliographic list. G.S. Kupriyanova – compiling the section “Application of the 1H NMR method for determining the concentration of drugs”, “Conclusion”, compiling a bibliographic list. I.G. Mershiev – compiling the section “Application of the 1H NMR method for determining the concentration of drugs”, “Conclusion”, compiling a bibliographic list. V.V. Rafalskiy – compiling the “Introduction” section, compiling the sections: “Materials and Methods”, “Using Raman scattering and giant Raman scattering to determine the concentration of drugs”, “Application of the 1H NMR method to determine the concentration of drugs”, “Conclusion”, compiling a bibliographic list. N.O. Kryukova – compiling sections “Use of Raman scattering of light and giant Raman scattering of light to determine the concentration of drugs”, “Application of the 1H NMR method to determine the concentration of drugs”. I.I. Kon. – compiling figures “Model images of the electric field amplification of the SERS sensor in the case of a single particle and a surface formed from metal particles”. I.G. Samusev – compiling the section “Application of the 1H NMR method for determining the concentration of drugs”, “Conclusion”, compiling a bibliographic list. Y.D. Belousova – compiling the “Introduction” section, compiling the sections: “Materials and Methods”. S.A. Doktorova – compiling the “Introduction” section, compiling the sections: “Materials and Methods”. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

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Received: 2022-04-14
Accepted: 2022-06-21
Published Online: 2022-09-28

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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Keywords for this article
pharmacokinetics; pharmacometabolomics; quantitative NMR analysis; Raman spectroscopy; therapeutic drug monitoring

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. News in DMPT: Leaders in Pharmacogenetics Section
  4. Reviews
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