Involvement of GABAergic and nitrergic systems in the anxiolytic and hypnotic effects of Curcuma longa: its interaction with anxiolytic-hypnotics
-
Ismail O. Ishola
,
Folashade O. Katola
Abstract
Objectives
Concurrent use of herbs with drugs have become a major healthcare problem. Herb-drug interactions could lead to therapeutic failure or toxicity. Hence, this study seeks to evaluate the impact of combining Curcuma longa rhizome (CL) with selected anxiolytic and hypnotic drugs.
Methods
CL (100, 200 or 400 mg/kg, p.o.) was administered to mice 1 h before subjecting the animals to elevated plus maze (EPM), hole board test (HBT), open field test (OFT) and rotarod test for anxiolytic-like effect as well as hexobarbitone-induced sleeping time (HIST) for hypnotic activity. The involvement of GABAergic and nitrergic systems in CL-induced anxiolytic and hypnotic actions were also evaluated. The effect of concurrent use of CL with midazolam, imipramine, nifedipine, propranolol and carbamazepine were evaluated in anxiolytic-hypnosis models.
Results
The peak anxiolytic-like effect of CL was obtained at 400 mg/kg in the EPM and hole-board test without affecting muscle coordination in the rotarod test while the peak hypnosis-potentiation was observed at 100 mg/kg. CL-induced anxiolytic-hypnotic-like effects were reversed by the pretreatment of mice with flumazenil or NG-nitro-l-arginine.
Conclusions
Curcuma longa possesses anxiolytic and hypnotic effects through its interaction with GABAergic and nitrergic systems. Conversely, co-administration of C. longa with midazolam potentiate barbiturate-induced hypnosis.
Acknowledgments
Authors are grateful to Mr. M. Chijioke of the Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos for his technical assistance.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Ethical approval: The experimental procedures were carried out in accordance with United States National Institute of Health Guidelines for Care and Use of Laboratory Animals in Biomedical Research (NIH, 1985).
References
1. Meng, Q, Liu, K. Pharmacokinetic interactions between herbal medicines and prescribed drugs: focus on drug metabolic enzymes and transporters. Curr Drug Metab 2014;15:791−807.10.2174/1389200216666150223152348Search in Google Scholar
2. Awortwe, C, Makiwane, M, Reuter, H, Muller, C, Louw, J, Rosenkranz, B. Critical evaluation of causality assessment of herb-drug interactions in patients. Br J Clin Pharmacol 2018;84:679−93. https://doi.org/10.1111/bcp.13490.Search in Google Scholar
3. Gouda, HN, Charlson, F, Sorsdahl, K, Ahmadzada, S, Ferrari, AJ, Erskine, H, et al.. Burden of non-communicable diseases in sub-Saharan Africa, 1990-2017: results from the Global Burden of Disease Study 2017. Lancet Glob Health 2019;7:e1375−87. https://doi.org/10.1016/S2214-109X(19)30374-2.Search in Google Scholar
4. Ammon, HP, Wahl, MA. Pharmacology of Curcuma longa. Planta Med 1991;57:1−7. https://doi.org/10.1055/s-2006-960004.Search in Google Scholar PubMed
5. Ayati, Z, Ramezani, M, Amiri, MS, Moghadam, AT, Rahimi, H, Abdollahzade, A, et al.. Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important Species (C. longa and C. zedoaria): a review. Curr Pharm Des 2019;25:871−935.10.2174/1381612825666190402163940Search in Google Scholar PubMed
6. Al-Jenoobi, FI, Al-Thukair, AA, Alam, MA, Abbas, FA, Al-Mohizea, AM, Alkharfy, KM, et al.. Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects. Eur J Drug Metab Pharmacokinet 2015;40:61−6. https://doi.org/10.1007/s13318-014-0180-2.Search in Google Scholar PubMed
7. Gilhotra, N, Dhingra, D. GABAergic and nitriergic modulation by curcumin for its antianxiety-like activity in mice. Brain Res 2010;1352:167−75.10.1016/j.brainres.2010.07.007Search in Google Scholar PubMed
8. Green, TA, Baracz, SJ, Everett, NA, Robinson, KJ, Cornish, JL. Differential effects of GABAA receptor activation in the prelimbic and orbitofrontal cortices on anxiety. Psychopharmacology (Berl) 2020;237:3237−47.10.1007/s00213-020-05606-9Search in Google Scholar PubMed
9. Ishola, IO, Akinyede, AA, Robert, AK, Omilabu, SA. Hepatoprotective and antioxidant activities of Hepacare®, a herbal formulation against carbon tetrachloride-induced liver injury. Drug Res 2015;65:30−9.10.1055/s-0034-1371829Search in Google Scholar PubMed
10. Ishola, IO, Chatterjee, M, Tota, S, Tadigopulla, N, Adeyemi, OO, Palit, G, et al.. Antidepressant and anxiolytic effects of amentoflavone isolated from Cnestis ferruginea in mice. Pharmacol Biochem Behav 2012;103:322−31.10.1016/j.pbb.2012.08.017Search in Google Scholar PubMed
11. Takeda, H, Tsuji, M, Matsumiya, T. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Eur J Pharmacol 1998;350:21−9.10.1016/S0014-2999(98)00223-4Search in Google Scholar
12. Owope, TE, Ishola, IO, Akinleye, MO, Oyebade, R, Adeyemi, OO. Antidepressant effect of Cnestis ferruginea Vahl ex DC (Connaraceae): involvement of Cholinergic, Monoaminergic and L-arginine-nitric oxide pathways. Drug Res 2016;66:235−45.10.1055/s-0035-1565174Search in Google Scholar PubMed
13. Ishola, IO, Olayemi, SO, Idowu, AR. Anticonvulsant, anxiolytic and hypnotic effects of aqueous bulb extract of Crinum glaucum A. chev (Amaryllidaceae): role of GABAergic and nitrergic systems. Pak J Biol Sci 2013;16:701−10.10.3923/pjbs.2013.701.710Search in Google Scholar PubMed
14. Akindele, AJ. Adeyemi, OO. Anxiolytic and sedative effects of Byrsocarpus coccineus Schum, and thonn. (Connaraceae) extract. Int J Appl Res Nat Prod 2010;3: 28−36.Search in Google Scholar
15. Kito, T, Shibata, R, Kondo, M, Yamamoto, T, Suzuki, H, Ishii, M, et al.. Nifedipine ameliorates ischemia-induced revascularization in diet-induced obese mice. Am J Hypertens 2012;25:401−6.10.1038/ajh.2011.239Search in Google Scholar PubMed
16. Ceremuga, TE, Helmrick, K, Kufahl, Z, Kelley, J, Keller, B, Philippe, F, et al.. Investigation of the anxiolytic and antidepressant effects of Curcumin, a compound from turmeric (Curcuma longa), in the adult male Sprague-Dawley rat. Holist Nurs Pract 2017;31:193−203.10.1097/HNP.0000000000000208Search in Google Scholar PubMed
17. Oyemitan, IA, Elusiyan, CA, Onifade, AO, Akanmu, MA, Oyedeji, AO, McDonald, AG. Neuropharmacological profile and chemical analysis of fresh rhizome essential oil of Curcuma longa (turmeric) cultivated in Southwest Nigeria. Toxicol Rep 2017;4:391−8.10.1016/j.toxrep.2017.07.001Search in Google Scholar PubMed PubMed Central
18. Walf, AA, Frye, CA. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc 2007;2:322−8.10.1038/nprot.2007.44Search in Google Scholar PubMed PubMed Central
19. Pitsikas, N. The role of nitric oxide (NO) donors in anxiety. Lights and shadows. Nitric Oxide 2018;77:6−11.10.1016/j.niox.2018.04.002Search in Google Scholar PubMed
20. Gulati, K, Rai, N, Ray, A. Nitric oxide and anxiety. Vitam Horm 2017;103:169−92.10.1016/bs.vh.2016.09.001Search in Google Scholar PubMed
21. Gilhotra, N, Dhingra, D. Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice. Prog Neuro Psychopharmacol Biol Psychiatry 2009;33:1502−7.10.1016/j.pnpbp.2009.08.012Search in Google Scholar PubMed
22. Calixto, AV, Duarte, FS, Duzzioni, M, Nascimento Häckl, LP, Faria, MS, De Lima, TC. Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze. Behav Brain Res 2010;207:112−7.10.1016/j.bbr.2009.09.037Search in Google Scholar
23. Zhu, LJ, Ni, HY, Chen, R, Chang, L, Shi, H-J, Qiu, D, et al.. Hippocampal nuclear factor kappa B accounts for stress-induced anxiety behaviors via enhancing neuronal nitric oxide synthase (nNOS)-carboxy-terminal PDZ ligand of nNOS-Dexras1 coupling. J Neurochem 2018;146:598−612.10.1111/jnc.14478Search in Google Scholar
24. Appiah-Opong, R, Commandeur, JN, van Vugt-Lussenburg, B, Vermeulen, NP. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 2007;235:83−91.10.1016/j.tox.2007.03.007Search in Google Scholar
25. Rodríguez Castaño, P, Parween, S, Pandey, AV. Bioactivity of Curcumin on the Cytochrome P450 enzymes of the Steroidogenic pathway. Int J Mol Sci 2019;20:4606. https://doi.org/10.3390/ijms20184606.Search in Google Scholar
26. Bostock, E, Kirkby, K, Garry, M, Taylor, B, Hawrelak, JA. Mania Associated with herbal medicines, other than Cannabis: a Systematic review and quality assessment of Case reports. Front Psychiatry 2018;9:280. https://doi.org/10.3389/fpsyt.2018.00280.Search in Google Scholar
27. Dasgupta, A, Hovanetz, M, Olsen, M, Wells, A, Actor, JK. Drug-herb interaction: effect of St John’s wort on bioavailability and metabolism of procainamide in mice. Arch Pathol Lab Med 2007;131:1094−8.10.5858/2007-131-1094-DIEOSJSearch in Google Scholar
28. Fugh-Berman, A. Herb-drug interactions. Lancet 2000;355:134−8.10.1016/S0140-6736(99)06457-0Search in Google Scholar
© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- A review on the clinical trials of repurposing therapeutic drugs, mechanisms and preventive measures against SARS-CoV-2
- Drugs intervention study in COVID-19 management
- Original Articles
- CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine
- Metabolizer phenotype prediction in different Peruvian ethnic groups through CYP2C9 polymorphisms
- Pharmacogenetic algorithm for predicting daily dose of warfarin in Caucasian patients of Czech origin
- Fear of Hypoglycemia in Adults with diabetes mellitus switching to Treatment with IDegAsp Co-formulation to Examine real-world setting: an observational study (The HATICE study)
- Involvement of GABAergic and nitrergic systems in the anxiolytic and hypnotic effects of Curcuma longa: its interaction with anxiolytic-hypnotics
- Quality control, HPTLC analysis, antioxidant and antimicrobial activity of hydroalcoholic extract of roots of qust (Saussurea lappa, C.B Clarke)
- Recombinant human hyaluronidase PH20-mediated dermal spreading activity in mice is not altered by steroids, antihistamines, or salicylic acid
- Short Communication
- TCF7L2 rs7903146 C>T gene polymorphism is not associated with hypoglycemia in sulfonylurea-treated type 2 diabetic patients
- Case Report
- Spinal and cerebral hematoma in systemic lupus erythematosus and antiphospholipid syndrome: is drug interaction the culprit?
Articles in the same Issue
- Frontmatter
- Reviews
- A review on the clinical trials of repurposing therapeutic drugs, mechanisms and preventive measures against SARS-CoV-2
- Drugs intervention study in COVID-19 management
- Original Articles
- CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine
- Metabolizer phenotype prediction in different Peruvian ethnic groups through CYP2C9 polymorphisms
- Pharmacogenetic algorithm for predicting daily dose of warfarin in Caucasian patients of Czech origin
- Fear of Hypoglycemia in Adults with diabetes mellitus switching to Treatment with IDegAsp Co-formulation to Examine real-world setting: an observational study (The HATICE study)
- Involvement of GABAergic and nitrergic systems in the anxiolytic and hypnotic effects of Curcuma longa: its interaction with anxiolytic-hypnotics
- Quality control, HPTLC analysis, antioxidant and antimicrobial activity of hydroalcoholic extract of roots of qust (Saussurea lappa, C.B Clarke)
- Recombinant human hyaluronidase PH20-mediated dermal spreading activity in mice is not altered by steroids, antihistamines, or salicylic acid
- Short Communication
- TCF7L2 rs7903146 C>T gene polymorphism is not associated with hypoglycemia in sulfonylurea-treated type 2 diabetic patients
- Case Report
- Spinal and cerebral hematoma in systemic lupus erythematosus and antiphospholipid syndrome: is drug interaction the culprit?
