Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing
-
Sai M. Surve
and
Srinath L. Thakur
Abstract
Background: The current understanding of the pathogenesis of periodontal disease has resulted in adjunctive use of various pharmacologic agents in periodontal therapy. The objective of this investigation was to assess the efficacy of atorvastatin and simvastatin (because of their pleiotropic properties) as an adjunct to dental scaling and root planing (SRP) by local delivery, i.e. placing them subgingivally, in the treatment of chronic periodontitis.
Methods: Local delivery systems for atorvastatin and simvastatin were prepared in sodium alginate suspension to be administered with calcium chloride solution. Patients diagnosed with chronic periodontitis were grouped as group 1, receiving SRP only (control), group 2, receiving SRP with subgingival delivery of 1.2% simvastatin, and group 3, receiving SRP with subgingival delivery of 1.2% atorvastatin. Clinical parameters and interleukin (IL) 1α levels in the gingival crevicular fluid (GCF) were assessed.
Results: All three groups showed significant reductions in clinical parameters and IL-1α levels in the GCF (p<0.05). However, the test groups did not show any statistically significant difference when compared with control.
Conclusions: Subgingivally delivered atorvastatin and simvastatin as an adjunct to SRP is efficacious but did not demonstrate any added benefit as compared with SRP alone.
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©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Review
- Clinical pharmacy service practice in a Chinese tertiary hospital
- Reviews in Population Pharmacogenomics
- CYP2D6 in Amerindians from Southern Mexico: low variability and higher frequency of functional alleles
- Pharmacogenetics of healthy volunteers in Puerto Rico
- Original Articles
- ABCG2/BCRP interaction with the sea grass Thalassia testudinum
- Effect of rifampicin pretreatment on the oral bioavailability of domperidone in healthy human volunteers
- Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing
- Case Report
- Fluvoxamine-associated oscillopsia and a role for personalized medication dosing
- Acknowledgment
Articles in the same Issue
- Frontmatter
- Review
- Clinical pharmacy service practice in a Chinese tertiary hospital
- Reviews in Population Pharmacogenomics
- CYP2D6 in Amerindians from Southern Mexico: low variability and higher frequency of functional alleles
- Pharmacogenetics of healthy volunteers in Puerto Rico
- Original Articles
- ABCG2/BCRP interaction with the sea grass Thalassia testudinum
- Effect of rifampicin pretreatment on the oral bioavailability of domperidone in healthy human volunteers
- Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing
- Case Report
- Fluvoxamine-associated oscillopsia and a role for personalized medication dosing
- Acknowledgment
