Asymptomatic elevation of liver enzymes due to levetiracetam: a case report
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Nitin K. Sethi
,
Prahlad K. Sethi
Abstract
Levetiracetam is a commonly used broad-spectrum anticonvulsant efficacious in both partial and generalized seizures. It has an extremely favorable side effect profile with few drug-drug interactions, low potential for hematological and hepatic toxicity, and thus has rapidly become the preferred drug in patients with traumatic brain injuries who need seizure prophylaxis. We report, here, a patient who was started on levetiracetam for seizure prophylaxis after developing large bifrontal-parietal traumatic subdural hematomas (SDH) following a fall from a horse necessitating bifrontal craniotomies for evacuation. The patient developed an asymptomatic elevation of the liver enzymes. The liver enzymes trended back to normal after levetiracetam was stopped, and topiramate was initiated in its place.
Conflict of interest statement
Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article.
Research funding: None declared.
Employment or leadership: Dr. Sethi serves as the Associate Editor of the Eastern Journal of Medicine. All the other authors have no relevant disclosures.
Honorarium: None declared.
References
1. US Prescribing Information Keppra® tablets and oral solution. Available at: http://www.ucb.com/products/product-list/cns/keppra. Accessed on December 12, 2012.Search in Google Scholar
2. Xiong N, Hou L, Lu N, Mohamed AA, Wang T, Huang Y. Probable levetiracetam-related serum alkaline phosphatase elevation. BMC Neurol 2012;12:97.10.1186/1471-2377-12-97Search in Google Scholar PubMed PubMed Central
©2013 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Viewing drug action as network perturbation in multiple scale systems
- Reviews
- Applying systems biology in drug discovery and development
- An update on the constitutive androstane receptor (CAR)
- Original Articles
- Mitragyna speciosa Korth leaves extracts induced the CYP450 catalyzed aminopyrine-N-demethylase (APND) and UDP-glucuronosyl transferase (UGT) activities in male Sprague-Dawley rat livers
- Fluorescence spectroscopic study for competitive binding of antidiabetic drugs and endogenous substances on serum albumin
- Silibinin hemisuccinate binding to proteins in plasma and blood cell/plasma partitioning in mouse, rat, dog and man in vitro
- Case Report
- Asymptomatic elevation of liver enzymes due to levetiracetam: a case report
- Recommendation Endorsed by ESPT
- Lexical fields of predictive and personalized medicine1)
