Analogue-Based Drug Discovery: Contributions to Medicinal Chemistry Principles and Drug Design Strategies. Microtubule Stabilizers as a Case in Point (special topic article)
Analogue-Based Drug Discovery: Contributions to Medicinal Chemistry Principles and Drug Design Strategies. Microtubule Stabilizers as a Case in Point (special topic article)
Mohammad H. El-Dakdouki and Paul W. Erhardt
Pure and Applied Chemistry , 2012
Vol. 84, No. 7, pp. 1479–1542
The benefits of utilizing marketed drugs as starting points to discover new therapeutic agents have been well documented within the IUPAC series of books that bear the title Analogue-based Drug Discovery (ABDD). Not as clearly demonstrated, however, is that ABDD also contributes to the elaboration of new basic principles and alternative drug design strategies that are useful to the field of medicinal chemistry in general. After reviewing the ABDD programs that have evolved around the area of microtubule-stabilizing chemo-therapeutic agents, the present article delineates the associated research activities that additionally contributed to general strategies that can be useful for prodrug design, identifying pharmacophores, circumventing multidrug resistance, and achieving targeted drug distribution.
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Articles in the same Issue
- Masthead
- From the Editor
- Contents
- The Times They Are a Changing . . .
- The Mother of All Molecules
- Repositioning the Chemical Sciences for African Development
- The Young Ambassadors for Chemistry Program Visits Tanzania
- On the Future of Drug Discovery
- Linking Science and Policy at Rio+20
- ICSU Grants Programme 2013 Call for Applications
- ICSU Issues Recommendations for Organizing International Scientific Meetings
- CHF Catalyst Series on Women in Chemistry
- The Global Young Academy Calls on Scientific Community to Promote Sustainability
- In Memoriam
- Impact of Nanotechnology on Chemistry: A Terminology Conundrum
- Chemical Kinetic Data Evaluation for Atmospheric Chemistry and the IUPAC Kinetics Database
- Global Chemical Safety and Sustainability
- Provisional Recommendations
- IUPAC Glossary of Terms Used in Immunotoxicology (IUPAC Recommendations 2012)
- Names and Symbols of the Elements with Atomic Numbers 114 and 116 (IUPAC Recommendations 2012)
- Analogue-Based Drug Discovery: Contributions to Medicinal Chemistry Principles and Drug Design Strategies. Microtubule Stabilizers as a Case in Point (special topic article)
- Macromolecular Symposia
- Periodic Tables on the World Wide Web
- Systematic and Trivial Nomenclature
- Advanced Materials: Stories of Innovation
- How Many Miles Have We Gone, InChI by InChI?
- Advanced Polymeric Materials
- Toxicology
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