Quantifying the Effects of Compound Combinations
Quantifying the Effects of Compound Combinations
As ever more combination therapies are applied in various areas of medicine, there is a growing need for quantitative descriptions of combination effects. While most of the scientific community has agreed on a basic standard for synergy, there is no consensus on quantifying the degree to which a combination may deviate from synergy, and no predictive models are accepted to serve as benchmarks.
This project will convene a working group, involving leading experts on combination effects, to (1) endorse the synergy criterion recommended at a recent meeting in Finland, (2) adopt standard measures of combination effect to quantify deviations from synergy, and (3) explore predictive combination-effect models for multiply-inhibited biological interaction networks.
For more information contact the Task Group Chairman Joseph Lehár <jlehar@combinatorx.com>.
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Articles in the same Issue
- Contents
- IUPAC’s Recognition of Chemists
- Chemical Education and Sustainable Development in Russia. Chemistry Clearing House
- Collaborative Trial Tests for Method Validation: Lessons to be Learned
- IUPAC Working Party on Structure and Properties of Commercial Polymers–History, Output, and Future Prospects
- John Pople
- XML in Chemical Education
- Executive Committee Looks at IUPAC's Role in the World
- 2004 Winners of the IUPAC Prize for Young Chemists
- Questionable Stereoformulas of Diastereomers
- Graphical Representation Standards for Chemical Structure Diagrams
- Explanatory Dictionary of Concepts in Toxicokinetics
- Chemistry's Contributions to Humanity–A Feasibility Study
- Bio-Physical Chemistry of Fractal Structures and Processes in Environmental Systems
- Quantifying the Effects of Compound Combinations
- XML in Chemistry and Chemical Identifiers
- XML-Based IUPAC Standard for Experimental and Critically Evaluated Thermodynamic Property Data Storage and Capture
- IUPAC Seeks Your Comments
- Kids and Science
- Bio-Based Polymers
- Advanced Materials
- Biological Polyesters
- Biotechnology
- Liquid Chromatography/Mass Spectrometry
- Chemistry for Agriculture
- Young Chemists
- Mark Your Calendar
