Prognostic significance of soluble CD25 in patients with sepsis: a prospective observational study

Chun-Mei Huang; Xin-Jie Xu; Wen-Qi Qi; Qin-Min Ge

doi:10.1515/cclm-2022-0068

Article

Prognostic significance of soluble CD25 in patients with sepsis: a prospective observational study

Chun-Mei Huang , Xin-Jie Xu , Wen-Qi Qi and Qin-Min Ge

Published/Copyright: February 28, 2022

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From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 60 Issue 6

Abstract

Objectives

The diagnosis of sepsis is challenging, the need for sensitive and specific diagnostic and prognostic biomarkers has not been met. Soluble CD25 (sCD25) is a readily available biomarker reported to represent the severity of the disease. This study aimed to assess the association between sCD25 and mortality in patients with sepsis.

Methods

In total, 329 adult patients with sepsis were screened through a prospective, observational study. We investigated the severity scores and sCD25 levels at admission to the intensive care unit (ICU), defined by sepsis (sepsis-3). The prognostic value of sCD25 was assessed using receiver operating characteristic (ROC) curves and binary logistic regression models in predicting unfavourable outcome. The correlations between variables and severity of disease were analysed by Spearman correlation tests.

Results

After entering the ICU, the sCD25 level and sequential organ failure assessment (SOFA) score were significantly higher in nonsurvivors than in survivors. The prognostic values estimated by the ROC curves were 0.678 for sCD25 and 0.945 for SOFA score at ICU admission. sCD25 had a modest ability to predict poor outcome. Logistic regression showed that increased levels of sCD25 were independently associated with unfavourable outcome. Spearman correlation tests showed that sCD25 levels were positively correlated with disease severity.

Conclusions

In sepsis patients, increased sCD25 levels were independently associated with poor clinical outcomes. Further research is needed to improve the understanding of the pathophysiology of this relationship.

Keywords: 28-day mortality; sepsis; SOFA score; soluble CD25

Corresponding author: Qin-Min Ge, Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, P.R. China, E-mail: geqinmin@xinhuamed.com.cn

Chun-Mei Huang, Xin-Jie Xu and Wen-Qi Qi have contributed equally to this work and should be considered co-first authors.

Acknowledgments

We thank the Emergency Department of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine for its comprehensive support for this study.

Research funding: None declared.
Author contribution: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The study was approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine and was carried out in accordance with the Declaration of Helsinki. All data were anonymized.

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Received: 2022-01-25

Revised: 2022-02-12

Accepted: 2022-02-14

Published Online: 2022-02-28

Published in Print: 2022-05-25

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Articles in the same Issue

https://doi.org/10.1515/cclm-2022-0068

Keywords for this article

28-day mortality; sepsis; SOFA score; soluble CD25