Abstract
Ojectives
Since health care budgets are limited and must be allocated efficiently, there is an economic pressure to reduce the costs of health care interventions. This study aims to investigate the cost of testing within a Clinical Chemistry laboratory.
Methods
This study was conducted in the Clinical Chemistry laboratory of the University Hospital UZ Brussel, Belgium, in which 156 tests were included and an average cost per test was calculated for the year 2018. Activity-based costing (ABC) was applied, using a top-down perspective. Costs were first allocated to different activity centers and subsequently to different tests. Number of tests, parameters, analyzers and time estimates were used as activity cost drivers.
Results
The blood glucose test on the point-of-care testing (POCT) analyzer Accu Chek Inform II had the lowest unit cost (€0.92). The determination of methanol, ethanol and isopropanol on the GC-FID (7820A) is the test with the highest unit cost (€129.42). In terms of average cost per test per activity center, core laboratory (€3.37) scored lowest, followed consecutively by POCT (€3.49), diabetes (€22.09), toxicology (€31.52), metabolic disorder (€41.53) and cystic fibrosis (€86.02). The cost per test was mainly determined by staff (57%), costs of support services (23%) and reagents (14%).
Conclusions
High-volume and automated tests have lower unit costs, as is the case with the core laboratory. ABC provides the ability to identify high average cost tests that can benefit from optimizations, such as focusing on automation or outsourcing low-volume tests that can benefit from economies of scale.
Acknowledgments
This study was part of a thesis in Master of Health Care Management and Policy at the KU Leuven University. We thank the management of UZ Brussel for allowing this study to be carried out and all those involved at UZ Brussel who participated in this study.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Not applicable.
Ethical approval: Not applicable.
References
1. Barletta, G, Zaninotto, M, Faggian, D, Plebani, M. Shop for quality or quantity? Volumes and costs in clinical laboratories. Clin Chem Lab Med 2013;51:295–301. https://doi.org/10.1515/cclm-2012-0415.Search in Google Scholar PubMed
2. Plebani, M, Lippi, G. Is laboratory medicine a dying profession? Blessed are those who have not seen and yet have believed. Clin Biochem 2010;43:939–41. https://doi.org/10.1016/j.clinbiochem.2010.05.015.Search in Google Scholar PubMed
3. Su, BG, Chen, SF, Yeh, SH, Shih, PW, Lin, CC. Cost evaluation of clinical laboratory in Taiwan’s National Health System by using activity-based costing. Clin Chem Lab Med 2016;54:1753–8. https://doi.org/10.1515/cclm-2016-0193.Search in Google Scholar PubMed
4. Mouseli, A, Barouni, M, Amiresmaili, M, Mirab Samiee, S, Vali, L. Cost-price estimation of clinical laboratory services based on activity-based costing: a case study from a developing country. Electron Phys 2017;9:4077–83. https://doi.org/10.19082/4077.Search in Google Scholar PubMed PubMed Central
5. Adane, K, Abiy, Z, Desta, K. The revenue generated from clinical chemistry and hematology laboratory services as determined using activity-based costing (ABC) model. Cost Eff Resour Alloc 2015;13:1–7. https://doi.org/10.1186/s12962-015-0047-7.Search in Google Scholar PubMed PubMed Central
6. Cooper, R, Kaplan, R. Activity-based systems: measuring the costs of resource usage. Account Horiz 1992;6:1–13.Search in Google Scholar
7. Kaplan, RS, Anderson, SR. Time-driven activity-based costing. Harv Bus Rev 2003;82:131–8.10.2139/ssrn.485443Search in Google Scholar
8. Kaplan, RS, Porter, ME. How to solve the cost crisis in health care understanding the value of health care. Harv Bus Rev 2011;89:47–64.Search in Google Scholar
9. Keel, G, Savage, C, Rafiq, M, Mazzocato, P. Time-driven activity-based costing in health care: a systematic review of the literature. Health Pol 2017;121:755–63. https://doi.org/10.1016/j.healthpol.2017.04.013.Search in Google Scholar PubMed
10. Kaplan, AL, Agarwal, N, Setlur, NP, Tan, HJ, Niedzwiecki, D, McLaughlin, N, et al.. Measuring the cost of care in benign prostatic hyperplasia using time-driven activity-based costing (TDABC). Healthcare 2015;3:43–8. https://doi.org/10.1016/j.hjdsi.2014.09.007.Search in Google Scholar PubMed
11. DiGioia, AM, Greenhouse, PK, Giarrusso, ML, Kress, JM. Determining the true cost to deliver total hip and knee arthroplasty over the full cycle of care: preparing for bundling and reference-based pricing. J Arthroplasty 2016;31:1–6. https://doi.org/10.1016/j.arth.2015.07.013.Search in Google Scholar PubMed
12. Plebani, M. Quality and future of clinical laboratories: the Vico’s whole cyclical theory of the recurring cycles. Clin Chem Lab Med 2018;56:901–8. https://doi.org/10.1515/cclm-2018-0009.Search in Google Scholar PubMed
13. Plebani, M. Clinical laboratory: bigger is not always better. Diagnosis 2018;5:41–6. https://doi.org/10.1515/dx-2018-0019.Search in Google Scholar PubMed
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Kinetics and biological characteristics of humoral response developing after SARS-CoV-2 infection: implications for vaccination
- Reviews
- The impact of interventions applied in primary care to optimize the use of laboratory tests: a systematic review
- Circulating tumor DNA (ctDNA) as a pan-cancer screening test: is it finally on the horizon?
- Opinion Paper
- Performance specifications for measurement uncertainty of common biochemical measurands according to Milan models
- General Clinical Chemistry and Laboratory Medicine
- Activity-based cost analysis of laboratory tests in clinical chemistry
- Audit of sweat chloride testing reveals analytical errors
- Comparison of different algorithms in laboratory diagnosis of alpha1-antitrypsin deficiency
- Interpretable machine learning model to detect chemically adulterated urine samples analyzed by high resolution mass spectrometry
- Prognostic role of Krebs von den Lungen-6 (KL-6) measurement in idiopathic pulmonary fibrosis: a systematic review and meta-analysis
- Evaluating chronic kidney disease in rural South Africa: comparing estimated glomerular filtration rate using point-of-care creatinine to iohexol measured GFR
- Reference Values and Biological Variations
- Pediatric reference intervals for endocrine markers and fertility hormones in healthy children and adolescents on the Siemens Healthineers Atellica immunoassay system
- Cardiovascular Diseases
- Independent and combined effects of biotin and hemolysis on high-sensitivity cardiac troponin assays
- Infectious Diseases
- Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers
- Clinical validation of the Siemens quantitative SARS-CoV-2 spike IgG assay (sCOVG) reveals improved sensitivity and a good correlation with virus neutralization titers
- Evaluation of the automated LIAISON® SARS-CoV-2 TrimericS IgG assay for the detection of circulating antibodies
- Lumipulse G SARS-CoV-2 Ag assay evaluation using clinical samples from different testing groups
- Letters to the Editors
- The impact of measurement uncertainty on the uncertainty of ordinal medical scores based on continuous quantitative laboratory results
- Effect of five different pneumatic tube carrier inserts on mechanical sample stress: a multicentre evaluation
- Critical role of pre-analytical aspects for the measurement of circulating calprotectin in serum or plasma as a biomarker for neutrophil-related inflammation
- Prospective serological evaluation of anti SARS-CoV-2 IgG and anti S1-RBD antibodies in a community outbreak
- Common laboratory tests as indicators of COVID-19 severity on admission at high altitude: a single-center retrospective study in Quito (ECUADOR)
- Protease-antiprotease imbalance in patients with severe COVID-19
- Iodine containing contrast media and urinary flow cytometry: an unknown interference in automated urine sediment analysis
- Prolymphocytic or Richter’s transformation of chronic lymphocytic leukemia?
- OGTT reproducibility in adults with impaired fasting glucose is nearly 65% with adoption of Italian SIBioC-SIPMeL recommendations
Articles in the same Issue
- Frontmatter
- Editorial
- Kinetics and biological characteristics of humoral response developing after SARS-CoV-2 infection: implications for vaccination
- Reviews
- The impact of interventions applied in primary care to optimize the use of laboratory tests: a systematic review
- Circulating tumor DNA (ctDNA) as a pan-cancer screening test: is it finally on the horizon?
- Opinion Paper
- Performance specifications for measurement uncertainty of common biochemical measurands according to Milan models
- General Clinical Chemistry and Laboratory Medicine
- Activity-based cost analysis of laboratory tests in clinical chemistry
- Audit of sweat chloride testing reveals analytical errors
- Comparison of different algorithms in laboratory diagnosis of alpha1-antitrypsin deficiency
- Interpretable machine learning model to detect chemically adulterated urine samples analyzed by high resolution mass spectrometry
- Prognostic role of Krebs von den Lungen-6 (KL-6) measurement in idiopathic pulmonary fibrosis: a systematic review and meta-analysis
- Evaluating chronic kidney disease in rural South Africa: comparing estimated glomerular filtration rate using point-of-care creatinine to iohexol measured GFR
- Reference Values and Biological Variations
- Pediatric reference intervals for endocrine markers and fertility hormones in healthy children and adolescents on the Siemens Healthineers Atellica immunoassay system
- Cardiovascular Diseases
- Independent and combined effects of biotin and hemolysis on high-sensitivity cardiac troponin assays
- Infectious Diseases
- Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers
- Clinical validation of the Siemens quantitative SARS-CoV-2 spike IgG assay (sCOVG) reveals improved sensitivity and a good correlation with virus neutralization titers
- Evaluation of the automated LIAISON® SARS-CoV-2 TrimericS IgG assay for the detection of circulating antibodies
- Lumipulse G SARS-CoV-2 Ag assay evaluation using clinical samples from different testing groups
- Letters to the Editors
- The impact of measurement uncertainty on the uncertainty of ordinal medical scores based on continuous quantitative laboratory results
- Effect of five different pneumatic tube carrier inserts on mechanical sample stress: a multicentre evaluation
- Critical role of pre-analytical aspects for the measurement of circulating calprotectin in serum or plasma as a biomarker for neutrophil-related inflammation
- Prospective serological evaluation of anti SARS-CoV-2 IgG and anti S1-RBD antibodies in a community outbreak
- Common laboratory tests as indicators of COVID-19 severity on admission at high altitude: a single-center retrospective study in Quito (ECUADOR)
- Protease-antiprotease imbalance in patients with severe COVID-19
- Iodine containing contrast media and urinary flow cytometry: an unknown interference in automated urine sediment analysis
- Prolymphocytic or Richter’s transformation of chronic lymphocytic leukemia?
- OGTT reproducibility in adults with impaired fasting glucose is nearly 65% with adoption of Italian SIBioC-SIPMeL recommendations