Startseite Medizin Precision medicine in medical oncology: hope, disappointment and reality
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Precision medicine in medical oncology: hope, disappointment and reality

  • Marie Bartoušková und Bohuslav Melichar EMAIL logo
Veröffentlicht/Copyright: 9. April 2020
Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine (CCLM) Band 58 Heft 9

Abstract

During the past 20 years, targeted therapy based on the understanding of tumor biology has been complementing or even replacing cytotoxic agents that have dominated pharmacotherapy of cancer since the conception of medical oncology. Unfortunately, the fact that targeted therapies with potential to induce cure or at least substantially prolong survival are still not available for many common solid tumors results in skepticism or even nihilism. On the one hand, biomarker research is not keeping pace with the introduction of new agents, while on the other hand, effective drugs are still not available for many potential molecular targets associated with malignant transformation and tumor progression. However, targeted therapies have already transformed the natural history and clinical outcomes not only in patients with rare malignancies like gastrointestinal stromal tumor but also with many common tumors, e.g. breast cancer, malignant melanoma, non-small cell lung cancer or renal cell carcinoma. For further advances, a multidisciplinary effort is indispensible that should, above all, involve the collaboration of medical oncology and laboratory medicine.

Keywords: biomarkers; cancer; immunotherapy; targeted therapy
Corresponding author: Bohuslav Melichar, MD, PhD, Professor and Head, Department of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic, Phone: +420-588444288, Fax: +420-588442522

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: IGA Univerzity Palackého, grant number: IGA_LF_2020_005.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2020-03-02
Published Online: 2020-04-09
Published in Print: 2020-08-27

©2020 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Measurement uncertainty: light in the shadows
  4. Review
  5. Childhood obesity: an overview of laboratory medicine, exercise and microbiome
  6. Mini review
  7. The utility of measurement uncertainty in medical laboratories
  8. Opinion Paper
  9. Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)?
  10. Opinion Papers
  11. The current status and future prospects of precision medicine
  12. Precision medicine in medical oncology: hope, disappointment and reality
  13. IFCC Papers
  14. Laboratory practices to mitigate biohazard risks during the COVID-19 outbreak: an IFCC global survey
  15. Operational considerations and challenges of biochemistry laboratories during the COVID-19 outbreak: an IFCC global survey
  16. Genetics and Molecular Diagnostics
  17. Diverse fragment lengths dismiss size selection for serum cell-free DNA: a comparative study of serum and plasma samples
  18. General Clinical Chemistry and Laboratory Medicine
  19. Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient
  20. Isotope dilution-LC-MS/MS method for quantification of the urinary cotinine-to-creatinine ratio
  21. A liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based assay to profile 20 plasma steroids in endocrine disorders
  22. Assessment of antinuclear antibodies by indirect immunofluorescence assay: report from a survey by the American Association of Medical Laboratory Immunologists
  23. Evaluation of a novel extended automated particle-based multi-analyte assay for the detection of autoantibodies in the diagnosis of primary biliary cholangitis
  24. Reference Values and Biological Variations
  25. Continuous, complete and comparable NT-proBNP reference ranges in healthy children
  26. Reference-mean-centered statistical quality control
  27. Hematology and Coagulation
  28. Top-down and bottom-up approaches for the estimation of measurement uncertainty in coagulation assays
  29. Cancer Diagnostics
  30. Tumor-associated exosomal miRNA biomarkers to differentiate metastatic vs. nonmetastatic non-small cell lung cancer
  31. Analysis of EGFR mutation status in malignant pleural effusion and plasma from patients with advanced lung adenocarcinoma
  32. Cardiovascular Diseases
  33. Establishing the 99th percentile of a novel assay for high-sensitivity troponin I in a healthy blood donor population
  34. The clinically effective use of cardiac markers by restructuring laboratory profiles at Cardiology wards
  35. Infectious Diseases
  36. Lower nasopharyngeal viral load during the latest phase of COVID-19 pandemic in a Northern Italy University Hospital
  37. SARS-CoV-2 RNA identification in nasopharyngeal swabs: issues in pre-analytics
  38. Rapid identification of SARS-CoV-2-infected patients at the emergency department using routine testing
  39. Evaluation of eleven rapid tests for detection of antibodies against SARS-CoV-2
  40. Development and multicenter performance evaluation of fully automated SARS-CoV-2 IgM and IgG immunoassays
  41. Letters to the Editor
  42. Evaluation of seven commercial SARS-CoV-2 RNA detection kits based on real-time polymerase chain reaction (PCR) in China
  43. Blood sampling after COVID-19 − How to organize large scale phlebotomy services in the post SARS CoV-2 era
  44. Diagnostic performance of a SARS-CoV-2 IgG/IgM lateral flow immunochromatography assay in symptomatic patients presenting to the emergency department
  45. Urinalysis parameters for predicting severity in coronavirus disease 2019 (COVID-19)
  46. Neutrophil-to-lymphocyte ratio predicts the clearance of SARS-CoV-2 RNA in mild COVID-19 patients – a retrospective analysis from Dongxihu Fangcang Hospital in Wuhan, China
  47. Low levels of total and ionized calcium in blood of COVID-19 patients
  48. Is “light cannabis” really light? Determination of cannabinoids content in commercial products
  49. Amino-terminal proB-type natriuretic peptide reference values in umbilical cord blood
  50. The new era of LED microscopes in immunofluorescence anti-nuclear antibody (ANA) testing
  51. The centrifuge brake impacts neither routine coagulation assays nor platelet count in platelet-poor plasma
https://doi.org/10.1515/cclm-2020-0231
Schlagwörter für diesen Artikel
biomarkers; cancer; immunotherapy; targeted therapy

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Measurement uncertainty: light in the shadows
  4. Review
  5. Childhood obesity: an overview of laboratory medicine, exercise and microbiome
  6. Mini review
  7. The utility of measurement uncertainty in medical laboratories
  8. Opinion Paper
  9. Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)?
  10. Opinion Papers
  11. The current status and future prospects of precision medicine
  12. Precision medicine in medical oncology: hope, disappointment and reality
  13. IFCC Papers
  14. Laboratory practices to mitigate biohazard risks during the COVID-19 outbreak: an IFCC global survey
  15. Operational considerations and challenges of biochemistry laboratories during the COVID-19 outbreak: an IFCC global survey
  16. Genetics and Molecular Diagnostics
  17. Diverse fragment lengths dismiss size selection for serum cell-free DNA: a comparative study of serum and plasma samples
  18. General Clinical Chemistry and Laboratory Medicine
  19. Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient
  20. Isotope dilution-LC-MS/MS method for quantification of the urinary cotinine-to-creatinine ratio
  21. A liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based assay to profile 20 plasma steroids in endocrine disorders
  22. Assessment of antinuclear antibodies by indirect immunofluorescence assay: report from a survey by the American Association of Medical Laboratory Immunologists
  23. Evaluation of a novel extended automated particle-based multi-analyte assay for the detection of autoantibodies in the diagnosis of primary biliary cholangitis
  24. Reference Values and Biological Variations
  25. Continuous, complete and comparable NT-proBNP reference ranges in healthy children
  26. Reference-mean-centered statistical quality control
  27. Hematology and Coagulation
  28. Top-down and bottom-up approaches for the estimation of measurement uncertainty in coagulation assays
  29. Cancer Diagnostics
  30. Tumor-associated exosomal miRNA biomarkers to differentiate metastatic vs. nonmetastatic non-small cell lung cancer
  31. Analysis of EGFR mutation status in malignant pleural effusion and plasma from patients with advanced lung adenocarcinoma
  32. Cardiovascular Diseases
  33. Establishing the 99th percentile of a novel assay for high-sensitivity troponin I in a healthy blood donor population
  34. The clinically effective use of cardiac markers by restructuring laboratory profiles at Cardiology wards
  35. Infectious Diseases
  36. Lower nasopharyngeal viral load during the latest phase of COVID-19 pandemic in a Northern Italy University Hospital
  37. SARS-CoV-2 RNA identification in nasopharyngeal swabs: issues in pre-analytics
  38. Rapid identification of SARS-CoV-2-infected patients at the emergency department using routine testing
  39. Evaluation of eleven rapid tests for detection of antibodies against SARS-CoV-2
  40. Development and multicenter performance evaluation of fully automated SARS-CoV-2 IgM and IgG immunoassays
  41. Letters to the Editor
  42. Evaluation of seven commercial SARS-CoV-2 RNA detection kits based on real-time polymerase chain reaction (PCR) in China
  43. Blood sampling after COVID-19 − How to organize large scale phlebotomy services in the post SARS CoV-2 era
  44. Diagnostic performance of a SARS-CoV-2 IgG/IgM lateral flow immunochromatography assay in symptomatic patients presenting to the emergency department
  45. Urinalysis parameters for predicting severity in coronavirus disease 2019 (COVID-19)
  46. Neutrophil-to-lymphocyte ratio predicts the clearance of SARS-CoV-2 RNA in mild COVID-19 patients – a retrospective analysis from Dongxihu Fangcang Hospital in Wuhan, China
  47. Low levels of total and ionized calcium in blood of COVID-19 patients
  48. Is “light cannabis” really light? Determination of cannabinoids content in commercial products
  49. Amino-terminal proB-type natriuretic peptide reference values in umbilical cord blood
  50. The new era of LED microscopes in immunofluorescence anti-nuclear antibody (ANA) testing
  51. The centrifuge brake impacts neither routine coagulation assays nor platelet count in platelet-poor plasma
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