Analytical challenges related to the use of biomarker ratios for the biological diagnosis of Alzheimer’s disease

Articles in the same Issue

1. Frontmatter
2. Editorials
3. Once upon a time: a tale of ISO 15189 accreditation
4. A new integrated tool for assessing and monitoring test comparability and stability
5. Liver-FibroSTARD checklist and glossary: tools for standardized design and reporting of diagnostic accuracy studies of liver fibrosis tests
6. Reviews
7. Thromboembolic risk in hematological malignancies
8. A review of the cut-off points for the diagnosis of vitamin B₁₂ deficiency in the general population
9. Opinion Paper
10. Permissible limits for uncertainty of measurement in laboratory medicine
11. EFLM Position Paper
12. Flexible scope for ISO 15189 accreditation: a guidance prepared by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group Accreditation and ISO/CEN standards (WG-A/ISO)
13. Genetics and Molecular Diagnostics
14. Evaluation of a low-cost procedure for sampling, long-term storage, and extraction of RNA from blood for qPCR analyses
15. Application of real-time PCR of sex-independent insertion-deletion polymorphisms to determine fetal sex using cell-free fetal DNA from maternal plasma
16. General Clinical Chemistry and Laboratory Medicine
17. The Empower project – a new way of assessing and monitoring test comparability and stability
18. Comparison of four automated serum vitamin B12 assays
19. Combined indicator of vitamin B₁₂ status: modification for missing biomarkers and folate status and recommendations for revised cut-points
20. INR vs. thrombin generation assays for guiding VKA reversal: a retrospective comparison
21. Determination of dabigatran in plasma, serum, and urine samples: comparison of six methods
22. Simple high-throughput analytical method using ultra-performance liquid chromatography coupled with tandem mass spectrometry to quantify total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine
23. Revival of physostigmine – a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients
24. Relationship between antiphosphatidylserine/prothrombin and conventional antiphospholipid antibodies in primary antiphospholipid syndrome
25. Reference Values and Biological Variations
26. Relevance of EDTA carryover during blood collection
27. Reference intervals for renal injury biomarkers neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in young infants
28. Cardiovascular Diseases
29. NT-proBNP levels and their relationship with systemic ventricular impairment in adult patients with transposition of the great arteries long after Mustard or Senning procedure
30. Letters to the Editors
31. Troponin T measured with highly sensitive assay (hsTnT) on admission does not reflect infarct size in ST-elevation myocardial infarction patients receiving primary percutaneous coronary intervention
32. Analytical challenges related to the use of biomarker ratios for the biological diagnosis of Alzheimer’s disease
33. Serum brain injury biomarkers as predictors of mortality after severe aneurysmal subarachnoid hemorrhage: preliminary results
34. Tumor markers assay by the Lumipulse G
35. Real-world costs of laboratory tests for non-small cell lung cancer
36. Impact of stopping vitamin K antagonist therapy on concentrations of dephospho-uncarboxylated Matrix Gla protein
37. Practicability of fetal scalp blood sampling during labor using microtubes and a point-of-care (POC) lactate testing device: difficulty assessment, sampling time and failure rates
38. Establishing objective analytical quality requirements in the IgE specific assay: a message in a bottle
39. Bacteria on a peripheral blood smear as presenting sign of overwhelming post-splenectomy infection in a patient with secondary acute myeloid leukemia