NT-proBNP levels and their relationship with systemic ventricular impairment in adult patients with transposition of the great arteries long after Mustard or Senning procedure
-
Karel Kotaska
,
Jana Popelova
Abstract
Background: The aim of the study was to investigate serum NT-proBNP levels in adult patients with transposition of the great arteries (d-TGA) corrected by atrial switch procedures (Mustard or Senning) operation and to assess the relationship with ventricular impairment and NYHA class.
Methods: Serum NT-proBNP levels were measured in a group of 81 consecutive adult patients (59 males, mean age 27 years and 22 females, mean age 28 years) with transposition of the great arteries (TGA) after surgical correction in childhood, and in a control group of 25 healthy individuals (16 males, mean age 32 years, and 9 females, mean age 29 years). Age-matched correlation of NT-proBNP concentrations in TGA patients after Mustard or Senning correction was performed, but this correlation was considered not significant (p=0.08).
Results: Concentrations of NT-proBNP in patients with TGA were significantly elevated compared to the control group of healthy individuals (203 ng/L vs. 41 ng/L, p<0.0001). Patients after the Mustard repair had significantly higher NT-proBNP values than patients after the Senning operation (234 ng/L vs. 148 ng/L, p=0.0023). NT-proBNP correlated negatively with the systemic right ventricular ejection fraction with the greatest significance in patients after Mustard correction (r=–0.32, p<0.0001). The concentration of NT-proBNP was also associated with NYHA functional class (p=0.0035) with the greatest significance in patients with Mustard correction (p=0.028).
Conclusions: Elevated levels of NT-proBNP appear to be a useful tool in assessing heart failure in patients with transposition of the great arteries after atrial switch correction.
Acknowledgments
Supported by Ministry of Health, Czech Republic – conceptual development of research organization: Hospital Na Homolce, Prague, Czech Republic – NNH, 00023884 and University Hospital Motol, Prague, Czech Republic 0006420.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Financial support: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Artikel in diesem Heft
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Artikel in diesem Heft
- Frontmatter
- Editorials
- Once upon a time: a tale of ISO 15189 accreditation
- A new integrated tool for assessing and monitoring test comparability and stability
- Liver-FibroSTARD checklist and glossary: tools for standardized design and reporting of diagnostic accuracy studies of liver fibrosis tests
- Reviews
- Thromboembolic risk in hematological malignancies
- A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population
- Opinion Paper
- Permissible limits for uncertainty of measurement in laboratory medicine
- EFLM Position Paper
- Flexible scope for ISO 15189 accreditation: a guidance prepared by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group Accreditation and ISO/CEN standards (WG-A/ISO)
- Genetics and Molecular Diagnostics
- Evaluation of a low-cost procedure for sampling, long-term storage, and extraction of RNA from blood for qPCR analyses
- Application of real-time PCR of sex-independent insertion-deletion polymorphisms to determine fetal sex using cell-free fetal DNA from maternal plasma
- General Clinical Chemistry and Laboratory Medicine
- The Empower project – a new way of assessing and monitoring test comparability and stability
- Comparison of four automated serum vitamin B12 assays
- Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points
- INR vs. thrombin generation assays for guiding VKA reversal: a retrospective comparison
- Determination of dabigatran in plasma, serum, and urine samples: comparison of six methods
- Simple high-throughput analytical method using ultra-performance liquid chromatography coupled with tandem mass spectrometry to quantify total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine
- Revival of physostigmine – a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients
- Relationship between antiphosphatidylserine/prothrombin and conventional antiphospholipid antibodies in primary antiphospholipid syndrome
- Reference Values and Biological Variations
- Relevance of EDTA carryover during blood collection
- Reference intervals for renal injury biomarkers neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in young infants
- Cardiovascular Diseases
- NT-proBNP levels and their relationship with systemic ventricular impairment in adult patients with transposition of the great arteries long after Mustard or Senning procedure
- Letters to the Editors
- Troponin T measured with highly sensitive assay (hsTnT) on admission does not reflect infarct size in ST-elevation myocardial infarction patients receiving primary percutaneous coronary intervention
- Analytical challenges related to the use of biomarker ratios for the biological diagnosis of Alzheimer’s disease
- Serum brain injury biomarkers as predictors of mortality after severe aneurysmal subarachnoid hemorrhage: preliminary results
- Tumor markers assay by the Lumipulse G
- Real-world costs of laboratory tests for non-small cell lung cancer
- Impact of stopping vitamin K antagonist therapy on concentrations of dephospho-uncarboxylated Matrix Gla protein
- Practicability of fetal scalp blood sampling during labor using microtubes and a point-of-care (POC) lactate testing device: difficulty assessment, sampling time and failure rates
- Establishing objective analytical quality requirements in the IgE specific assay: a message in a bottle
- Bacteria on a peripheral blood smear as presenting sign of overwhelming post-splenectomy infection in a patient with secondary acute myeloid leukemia
