Cardiac troponin T detection using polymers coated quartz crystal microbalance as a cost-effective immunosensor
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Krongkamol Wong-ek
Abstract
Cardiac troponin T (cTnT) detection has been the focus of increased interest due to its role in myocardial infarction diagnosis. In this study, we report a relatively low coat technique to detect cTnT using a quartz crystal microbalance (QCM) sensor. A sensitive detection is achieved by introducing a QCM surface with a carboxylic polyvinyl chloride immobilization layer. The surface morphologies of this polymer film under varied deposition thickness have been investigated by field emission scanning electron microscopy and atomic force microscopy. A cTnT detection result from a modified QCM surface can be obtained within a short response time by a direct detection of the immunoreaction and a direct conversion of mass accumulation into a frequency shift, representing a measurable electrical signal. The relationship between the cTnT concentration and the response current from a QCM sensor shows detectability at the concentration of cTnT as low as 5 ng/ml.
©2010 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Review
- Zementfreie Hüftendoprothetik: eine aktuelle Übersicht / Cementless total hip arthroplasty: a review
- Research articles
- Relative contributions of plantar fascia and ligaments on the arch static stability: a finite element study
- Development of a device to simulate tooth mobility
- Cardiac troponin T detection using polymers coated quartz crystal microbalance as a cost-effective immunosensor
- Super-selective electrical stimulation of the left ventricle via a miniaturized magnetized stimulation wire: proof of concept study
- Clinical proof of practicability for an ECG device without any conductive contact
- Hybrid independent component analysis and twin support vector machine learning scheme for subtle gesture recognition
