Progress and perspectives in total body PET systems instrumentation
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Stefaan Vandenberghe
Abstract
Total body positron emission tomography (PET) systems are being developed by different groups worldwide. These systems have potential to change the number of applications in which molecular imaging is used. The change from a short axial field of view (FOV) to a longer one is however associated with a linear increase in the cost of these systems. This may limit their application to a small number of centers (capable of obtaining sufficient research funding). Therefore it remains interesting to see if lower cost systems can be developed and bring total body PET to the clinic for an acceptable budget. The wider availability of this low cost system can also enable more researchers to further optimize and explore the full potential of total body PET.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The local Institutional Review Board deemed the study exempt from review.
References
1. Muehllehner, G, Karp, JS. Positron emission tomography. Phys Med Biol 2006;51:117–37. https://doi.org/10.1088/0031-9155/51/13/R08.Suche in Google Scholar
2. Lewellen, TK. Recent developments in PET detector technology. Phys Med Biol 2008;53:287. https://doi.org/10.1088/0031-9155/53/17/R01.Suche in Google Scholar
3. Peng, BH, Levin, CS. Recent development in PET instrumentation. Curr Pharmaceut Biotechnol 2010;11:555–71. https://doi.org/10.2174/138920110792246555.Suche in Google Scholar
4. Karp, JS, Surti, S, Daube-Witherspoon, ME, Muehllehner, G. Benefit of time-of-flight in PET: experimental and clinical results. J Nucl Med 2008;49:462–70. https://doi.org/10.2967/jnumed.107.044834.Suche in Google Scholar
5. Surti, S, Karp, JS. Advances in time-of-flight pet. Phys Med 2016;32:12–22. https://doi.org/10.1016/j.ejmp.2015.12.007.Suche in Google Scholar
6. Britvitch, I, Johnson, I, Renker, D, Stoykov, A, Lorenz, E. Characterisation of Geiger-mode avalanche photodiodes for medical imaging applications. Nucl Instrum Methods Phys Res Sect A Accel Spectrom Detect Assoc Equip 2007;571:308–11. https://doi.org/10.1016/j.nima.2006.10.089.Suche in Google Scholar
7. Roncali, E, Cherry, SR. Application of silicon photomultipliers to positron emission tomography. Ann Biomed Eng 2011;39:1358–77.10.1007/s10439-011-0266-9Suche in Google Scholar PubMed PubMed Central
8. Surti, S, Karp, JS. Impact of detector design on imaging performance of a long axial field-of-view, whole-body PET scanner. Phys Med Biol 2015;60:5343–58. https://doi.org/10.1088.10.1088/0031-9155/60/13/5343Suche in Google Scholar PubMed PubMed Central
9. Schmall, JP, Karp, JS, Werner, M, Surti, S. Parallax error in long-axial field-of-view PET scanners—a simulation study. Phys Med Biol 2016;61:5443–55. https://doi.org/10.1088.10.1088/0031-9155/61/14/5443Suche in Google Scholar PubMed PubMed Central
10. Eriksson, L, Townsend, D, Conti, M, Eriksson, M, Rothfuss, H, Schmand, M, et al.. An investigation of sensitivity limits in pet scanners. Nucl Instrum Methods Phys Res Sect A Accel Spectrom Detect Assoc Equip 2007;580:836–42.10.1016/j.nima.2007.06.112Suche in Google Scholar
11. Cherry, S, Karp, J, Moses, W, Qi, J, Bec, J, Berg, E, et al.. In: Proceedings of IEEE nuclear science symposium and medical imaging conference; 2013. M03–01.Suche in Google Scholar
12. Badawi, RD, Shi, H, Hu, P, Chen, S, Xu, T, Price, PM, et al.. First human imaging studies with the explorer total-body pet scanner. J Nucl Med 2019;60:299–303.10.2967/jnumed.119.226498Suche in Google Scholar PubMed PubMed Central
13. Karp, JS, Vishwanath, V, Geagan, M, Muehllehner, G, Pantel, A, Parma, M, et al.. Pennpet explorer: design and preliminary performance of a whole-body imager. J Nucl Med 2020;61:136–43.10.2967/jnumed.119.229997Suche in Google Scholar PubMed PubMed Central
14. Stockhoff, M, Decuyper, M, Van Holen, R, Vandenberghe, S. High-resolution monolithic LYSO detector with 6-layer depth-of-interaction for clinical PET. Phys Med Biol 2021;66:155014.10.1088/1361-6560/ac1459Suche in Google Scholar PubMed
15. Vandenberghe, S, Moskal, P, Karp, JS. State of the art in total body PET. EJNMMI Phys 2020;7:35.10.1186/s40658-020-00290-2Suche in Google Scholar PubMed PubMed Central
16. Surti, S, Werner, M, Karp, J. Study of pet scanner designs using clinical metrics to optimize the scanner axial fov and crystal thickness. Phys Med Biol 2013;58:3995.10.1088/0031-9155/58/12/3995Suche in Google Scholar PubMed PubMed Central
17. Moskal, P, Stępień, EŁ. Prospects and clinical perspectives of total-body PET imaging using plastic scintillators. Pet Clin 2020;15:439–52.10.1016/j.cpet.2020.06.009Suche in Google Scholar PubMed
18. Beltrame, P, Bolle, E, Braem, A, Casella, C, Chesi, E, Clinthorne, N, et al.. The ax-pet demonstrator design, construction and characterization. Nucl Instrum Methods Phys Res Sect A Accel Spectrom Detect Assoc Equip 2011;654:546–59.10.1016/j.nima.2011.06.059Suche in Google Scholar
19. Moskal, P, Salabura, P, Silarski, M, Smyrski, J, Zdebik, J, Zieliński, M. Novel detector systems for the positron emission tomography. Bio Algorithm Med Syst 2011;7:73.Suche in Google Scholar
20. Moskal, P, Rundel, O, Alfs, D, Bednarski, T, Białas, P, Czerwiński, E, et al.. Time resolution of the plastic scintillator strips with matrix photomultiplier readout for J-PET tomograph. Phys Med Biol 2016;61:2025.10.1088/0031-9155/61/5/2025Suche in Google Scholar PubMed
21. Moskal, P, Kowalski, P, Shopa, RY, Raczyński, L, Baran, J, Chug, N, et al.. Simulating NEMA characteristics of the modular total-body J-PET scanner – an economic total-body PET from plastic scintillators. Phys Med Biol 2021;66:175015.10.1088/1361-6560/ac16bdSuche in Google Scholar PubMed
22. Catana, C. The dawn of a new era in low-dose pet imaging. Radiology 2019;290:657–8.10.1148/radiol.2018182573Suche in Google Scholar PubMed
23. Kaplan, S, Zhu, YM. Full-dose pet image estimation from low-dose pet image using deep learning: a pilot study. J Digit Imag 2018:1–6.10.1007/s10278-018-0150-3Suche in Google Scholar PubMed PubMed Central
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial
- New trends in theranostics
- Reviews
- Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine
- Research Articles
- Theranostics – present and future
- Peptide receptor radionuclide therapy as a tool for the treatment of severe hypoglycemia in patients with primary inoperable insulinoma
- History of radiotherapy in Poland. A brief outline of the problem
- Reviews
- Radioactive nuclei for β+γ PET and theranostics: selected candidates
- Prospects for the production of radioisotopes and radiobioconjugates for theranostics
- History of positron emission tomography (PET) in Poland
- Progress and perspectives in total body PET systems instrumentation
- Perspectives of brain imaging with PET systems
- Combined BNCT and PET for theranostics
- Novel biomarker and drug delivery systems for theranostics – extracellular vesicles
- Positronium as a biomarker of hypoxia
Artikel in diesem Heft
- Frontmatter
- Editorial
- New trends in theranostics
- Reviews
- Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine
- Research Articles
- Theranostics – present and future
- Peptide receptor radionuclide therapy as a tool for the treatment of severe hypoglycemia in patients with primary inoperable insulinoma
- History of radiotherapy in Poland. A brief outline of the problem
- Reviews
- Radioactive nuclei for β+γ PET and theranostics: selected candidates
- Prospects for the production of radioisotopes and radiobioconjugates for theranostics
- History of positron emission tomography (PET) in Poland
- Progress and perspectives in total body PET systems instrumentation
- Perspectives of brain imaging with PET systems
- Combined BNCT and PET for theranostics
- Novel biomarker and drug delivery systems for theranostics – extracellular vesicles
- Positronium as a biomarker of hypoxia
