Early effect of thalamotomy on cognitive function in patients with Parkinson’s disease
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Edward J. Gorzelańczyk
Abstract
Thalamotomy is a neurosurgical procedure used in the treatment of advanced Parkinson’s disease (PD). The aim of our research is to evaluate the early impact of a lesion in the ventrointermedial nucleus (VIM) of the thalamus on cognitive and motor function in people with PD. Sixty patients who qualified for right- or left-sided VIM thalamotomy were involved in the study. The cognitive and motor functions of each patient were assessed both prior to and following the surgical procedure. Twenty-nine PD patients without ablative treatment were qualified for the comparison group, and 57 neurologically healthy individuals were assigned to the control group. The following tests were carried out: Mini Mental State Examination, Benton Visual Retention Test, Stroop Color and Word Test, Trail Making Test A&B, and Rey Auditory Verbal Learning Test. Statistically significant differences were found in reaction time, visual-spatial working memory, auditory-verbal memory, and overall level of cognitive function when comparing the results of tests carried out before and after thalamotomy and when comparing patients who had undergone surgery with untreated or healthy individuals. In patients with right-sided and left-sided thalamotomy differences were also found in the mean number of perseverative errors and recalled words.
Funding source: Ministry of Science and Higher Education
Award Identifier / Grant number: 2863/H03/2006/31
Funding statement: Ministry of Science and Higher Education (Poland); Project title: “Effect thalamotomy cognitive function and severity of depression in patients with Parkinson’s disease”; Project ID: 2863/H03/2006/31, Funder Id: 10.13039/501100004569.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
Ethical approval: To conduct the study, the consent of the Bioethics Commission at Collegium Medicum in Bydgoszcz and Nicolaus Copernicus University in Toruń was obtained (Consents no. KB/429/2004 and KB/743/2007). Patients gave voluntary consent to participate in the study.
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Articles in the same Issue
- Review
- Chromatin 3D – will it make understanding of cancer transformation finally possible?
- Research Articles
- Comparative studies on variability, phylogenesis, and correlated mutations of neuraminidases from influenza virus type A
- Creating and validating e-cases as educational tools in general practitioners’ continuing medical education context
- Visualization of the human eye
- Vision-based assessment of viability of acorns using sections of their cotyledons during automated scarification procedure
- Early effect of thalamotomy on cognitive function in patients with Parkinson’s disease
- Opinion Paper
- Missing data in open-data era – a barrier to multiomics integration
