Drug generations that combat influenza A virus infection
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Gabriela Żaroffe
,
Jacek Leluk
Abstract
Influenza viruses are significant human respiratory pathogens that cause infections and unpredictable pandemic outbreaks. M2 ion-channel protein, participating in the transmission of viral genetic materials into infected cells, is considered to be the crucial target for old-generation drugs such as rimantadine and amantadine. Neuraminidase protein, which is responsible for the replication of the influenza virus, is affected by the new generation of drugs, including oseltamivir (Tamiflu) and zanamivir (Relenza). The virus mutations that cause oseltamivir resistance are also described. This review presents the details concerning the treatment of influenza neuraminidase inhibitors against the H5N1 strain. It also describes virus mutations that cause resistance to oseltamivir and presents a new drug, peramivir, which is a neuraminidase inhibitor that was introduced against the H1N1 epidemic. This work specifies the details of the pharmacokinetics, dosing, toxicity, side effects, and efficiency of the drugs being used against influenza A virus infections.
Author contributions: The authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Drug generations that combat influenza A virus infection
- Research Articles
- Structure of hydrophobic core in plant carboxylesterase
- Correlated mutations in hydroxysteroid dehydrogenases family
- Efficiency testing of artificial neural networks in predicting the properties of carbon nanomaterials as potential systems for nervous tissue stimulation and regeneration
- Computational gait analysis using fuzzy logic for everyday clinical purposes – preliminary findings
- Sleep-related breathing biomarkers as a predictor of vital functions
Articles in the same Issue
- Frontmatter
- Review
- Drug generations that combat influenza A virus infection
- Research Articles
- Structure of hydrophobic core in plant carboxylesterase
- Correlated mutations in hydroxysteroid dehydrogenases family
- Efficiency testing of artificial neural networks in predicting the properties of carbon nanomaterials as potential systems for nervous tissue stimulation and regeneration
- Computational gait analysis using fuzzy logic for everyday clinical purposes – preliminary findings
- Sleep-related breathing biomarkers as a predictor of vital functions
