Intrahepatic cholestasis of pregnancy: detection with urinary bile acid assays
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William M. Huang
Abstract
Aims: To determine sensitivity and specificity of urine bile acid sulfate (UBAS) and non-sulfated urine bile acid (UBA) assays for detection of intrahepatic cholestasis of pregnancy (ICP).
Methods: Urine was collected prospectively from healthy and pruritic patients evaluated for ICP. Results were expressed as a ratio to urinary creatinine.
Results: Of 20 patients evaluated for ICP, 14 had confirmed ICP by serum testing and six had pruritus only. UBAS results were higher with ICP (P<0.001) and increased with gestational age in healthy controls. Adjusted for gestational age, the multiples of the median (MoM) were still higher (2.64±1.11, 1.05±0.54, P<0.001). The sensitivity was 100% and specificity 83% at 1.5 MoM in pruritic patients. UBA results were higher with ICP (23.0±9.8, 12.8±7.4, P<0.001), with sensitivity of 100% and specificity of 50% at 10.2 μmol/g cretinine.
Conclusion: Urinary bile acids can detect or exclude ICP with serum abnormalities. Urine bile acid sulfates have higher specificity than non-sulfated urine bile acids at equivalent sensitivities, but co-detection of progestin sulfates is suspected.
©2007 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Index Volume 35 (2007)
- Index - Authors
- Acknowledgement
- Index - Subjects
- Editorial
- The Istanbul international consensus statement on the perinatal care of multiple pregnancy
- Uterine activity monitoring during labor
- Is non-directive counseling for patient choice cesarean delivery ethically justified?
- GDM women in good glycemic control: which meal-related measure enhances fetal well-being?
- Intrahepatic cholestasis of pregnancy: detection with urinary bile acid assays
- Elevated blood lead levels in pregnant women: identification of a high-risk population and interventions
- Correlation of transthoracic echocardiography and right heart catheterization in pregnancy
- Adiponectin in severe preeclampsia
- Resistin: a hormone which induces insulin resistance is increased in normal pregnancy
- Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women
- Impact of the new French clinical practice recommendations in embolization in postpartum and post-abortion hemorrhage: study of 48 cases
- The relationship between congenital malformations and preterm birth
- Obstetrical factors for death and brain injury among extremely-low-birth-weight infants
- Early detection of a congenital coronary artery fistula in a neonate by Doppler color flow mapping
- The exit procedure (ex-utero intrapartum treatment): management of giant fetal cervical teratoma
- Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model
- Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model
- Recurrent pregnancy loss
- Congress Calendar
Articles in the same Issue
- Index Volume 35 (2007)
- Index - Authors
- Acknowledgement
- Index - Subjects
- Editorial
- The Istanbul international consensus statement on the perinatal care of multiple pregnancy
- Uterine activity monitoring during labor
- Is non-directive counseling for patient choice cesarean delivery ethically justified?
- GDM women in good glycemic control: which meal-related measure enhances fetal well-being?
- Intrahepatic cholestasis of pregnancy: detection with urinary bile acid assays
- Elevated blood lead levels in pregnant women: identification of a high-risk population and interventions
- Correlation of transthoracic echocardiography and right heart catheterization in pregnancy
- Adiponectin in severe preeclampsia
- Resistin: a hormone which induces insulin resistance is increased in normal pregnancy
- Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women
- Impact of the new French clinical practice recommendations in embolization in postpartum and post-abortion hemorrhage: study of 48 cases
- The relationship between congenital malformations and preterm birth
- Obstetrical factors for death and brain injury among extremely-low-birth-weight infants
- Early detection of a congenital coronary artery fistula in a neonate by Doppler color flow mapping
- The exit procedure (ex-utero intrapartum treatment): management of giant fetal cervical teratoma
- Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model
- Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model
- Recurrent pregnancy loss
- Congress Calendar
