Atosiban versus usual care for the management of preterm labor
-
Peter Husslein
Abstract
Objective: To compare the efficacy of atosiban with usual management of threatened preterm labor.
Methods: In this prospective, open-label, randomized controlled trial, women admitted to the hospital in threatened preterm labor (between 24 and 34 weeks' gestation) were randomized to receive atosiban or usual care (β-agonists, calcium channel blockers, magnesium sulphate, or any other tocolytic, alone or in combination, and/or bed rest).
Results: In women randomized to receive atosiban (n=295) or usual care (n=290), significantly more women receiving atosiban remained undelivered at 48 h with no alternative tocolytic compared with usual care (77.6% vs. 56.6%; P<0.001). The proportion of women remaining undelivered after 48 h was comparable between the treatment groups. However, more women in the atosiban group required no additional tocolytics (85.1% vs. 62.8%; P<0.001). Maternal and fetal safety was significantly superior with atosiban. Neonatal safety was comparable.
Conclusions: These findings support the use of atosiban to delay preterm birth and are consistent with previously conducted, randomized, controlled trials. Atosiban was associated with fewer maternal and fetal adverse events compared with other tocolytics, and presented no safety concerns for either the mother or the unborn baby.
©2007 by Walter de Gruyter Berlin New York
Articles in the same Issue
- WAPM-Newsletter No 1/2007 8th WORLD CONGRESS OF PERINATAL MEDICINE in Florence, Italy, September 9–13, 2007
- Poverty and perinatal health
- Maternal mortality in Africa
- Lessons learned from four advanced abdominal pregnancies at an East African Health Center
- Incidence and correlates of cesarean section in a capital city of a middle-income country
- Metabolic changes, hypothalamo-pituitary-adrenal axis and oxidative stress after short-term starvation in healthy pregnant women
- Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy?
- Feasibility of a randomized controlled trial testing nifedipine vs. placebo for the treatment of preterm labor
- Atosiban versus usual care for the management of preterm labor
- Umbilical cord blood collection: do patients really understand?
- Comparison between singleton- and triplet-specific “growth” curves to detect growth restricted triplet infants
- Role of visfatin, insulin-like growth factor-I and insulin in fetal growth
- Dynamic QT/RR relationship of cardiac conduction in premature infants treated with low-dose doxapram hydrochloride
- Risk factors and outcomes for ventilator-associated pneumonia in neonatal intensive care unit patients
- Neonatal outcomes in triplet pregnancies: assisted reproduction versus spontaneous conception
- Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome
- Vacuum extraction and autonomic balance in human infants
- Accuracy of second trimester fetal head circumference and biparietal diameter for predicting the time of spontaneous birth
- Reply
- Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix
- Reply
- In memoriam: Prof. Shouichi Sakamoto
- Congress Calendar
Articles in the same Issue
- WAPM-Newsletter No 1/2007 8th WORLD CONGRESS OF PERINATAL MEDICINE in Florence, Italy, September 9–13, 2007
- Poverty and perinatal health
- Maternal mortality in Africa
- Lessons learned from four advanced abdominal pregnancies at an East African Health Center
- Incidence and correlates of cesarean section in a capital city of a middle-income country
- Metabolic changes, hypothalamo-pituitary-adrenal axis and oxidative stress after short-term starvation in healthy pregnant women
- Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy?
- Feasibility of a randomized controlled trial testing nifedipine vs. placebo for the treatment of preterm labor
- Atosiban versus usual care for the management of preterm labor
- Umbilical cord blood collection: do patients really understand?
- Comparison between singleton- and triplet-specific “growth” curves to detect growth restricted triplet infants
- Role of visfatin, insulin-like growth factor-I and insulin in fetal growth
- Dynamic QT/RR relationship of cardiac conduction in premature infants treated with low-dose doxapram hydrochloride
- Risk factors and outcomes for ventilator-associated pneumonia in neonatal intensive care unit patients
- Neonatal outcomes in triplet pregnancies: assisted reproduction versus spontaneous conception
- Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome
- Vacuum extraction and autonomic balance in human infants
- Accuracy of second trimester fetal head circumference and biparietal diameter for predicting the time of spontaneous birth
- Reply
- Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix
- Reply
- In memoriam: Prof. Shouichi Sakamoto
- Congress Calendar
