Increased soluble VCAM-1 serum levels in preeclampsia are not correlated to urinary excretion or circadian blood pressure rhythm
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W. Heyl
Abstract
Objective: Soluble vascular cell adhesion molecule-1 (VCAM-1) is known to be elevated in serum of patients with preeclampsia, but there are no data available on the significance of urinary VCAM-1 excretion in preeclampsia. The aim of our study was to uncover possible circadian rhythms of VCAM-1 plasma levels and urinary VCAM-1 excretion in uncomplicated and hypertensive pregnancies and to ascertain their relation to blood pressure.
Study design: A total of 10 normotensive and 10 preeclamptic pregnant women were included in this study. Venous blood was collected hourly, and urine samples were taken every 2 h over a period of 24 h. VCAM-1 levels were determined by ELISA. We compared these results with the circadian blood pressure rhythm.
Results: The median VCAM-1 plasma levels were significantly (P<0.01) increased in preeclamptic patients (851.5 ng/mL) in comparison to normotensive pregnant women (659.3 ng/mL) without any circadian rhythm being apparent; however, the urinary excretion of VCAM-1 showed a typical circadian rhythm, with a higher excretion rate during daytime.
Conclusion: For the first time we have demonstrated that urinary VCAM-1 excretion in pregnancy shows a circadian rhythm without correlation to plasma levels or the circadian blood pressure rhythm. In contrast, VCAM-1 serum levels did not show a diurnal rhythm. We assume that VCAM-1 serum levels do not correlate with systemic blood pressure or urinary excretion.
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©2005 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Declining fertility in the developed world and high maternal mortality in developing countries – how do we respond?
- Maternal obesity and complications during pregnancy
- Cesarean section upon request: is it appropriate for everybody?
- Reply to: Cesarean section upon request: is it appropriate for everybody?
- Characteristics of mothers who delivered the heaviest, average-weight, and lightest triplet sets
- Gestational age-specific distribution of twin birth weight discordance
- The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy
- Optimal timing for postprandial glucose measurement in pregnant women with diabetes and a non-diabetic pregnant population evaluated by the Continuous Glucose Monitoring System (CGMS®)
- Structural-tridimensional study of yolk sac in pregnancies complicated by diabetes
- Is cervical dilatation during parturition at term associated with apoptosis?
- Increased soluble VCAM-1 serum levels in preeclampsia are not correlated to urinary excretion or circadian blood pressure rhythm
- The association of birthweight with maternal and cord serum and amniotic fluid growth hormone and insulin levels, and with neonatal and maternal factors in pregnant women who delivered at term
- Amniotic fluid lamellar body counts for the determination of fetal lung maturity: an update
- Comparison of clinical criteria with echocardiographic findings in diagnosing PDA in preterm infants
- Sudden infant death syndrome “gray zone” disclosed only by a study of the brain stem on serial sections
- Incidence and diagnosis of unilateral arterial cerebral infarction in newborn infants
- Non-hydropic intrauterine fetal death more than 5 months after primary parvovirus B19 infection
- A new syndrome of myopathy with muscle spindle excess*
- Causes of left ventricular hypertrabeculation/non-compaction in a neonate and her mother
