Renal vein thrombosis in a newborn with prothrombotic genetic risk factors
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Paola Giordano
Abstract
Environmental and genetic risk factors interact to cause venous thromboembolism. Renal vein thrombosis in the newborn has been frequently associated with “risk factors” as catheters, surgery or trauma, but it has also been demonstrated a pathogenetic role of genetic prothrombotic risk factors, i. e. activated protein C resistance and FV Leiden. The treatment of neonatal venous thrombosis varies worldwide and different approaches have been proposed. We present a case of renal vein thrombosis in a female newborn with normal plasma levels of protein C, protein S and antithrombin III, but with her genotype characterized by the presence of three prothrombotic risk factors: factor V Leiden, methylentetrahydrofolate reductase and platelet glycoprotein IIIa polymorphisms. The treatment with recombinant tissue plasminogen determined complete thrombus dissolution.
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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- WAPM-Newsletter No 1
Articles in the same Issue
- Malignant disease in pregnancy
- Repeated ultrasound guided fetal injections of corticosteroid alter nervous system maturation in the ovine fetus
- Incidence and birth weight characteristics of twins born to mothers aged 40 years or more compared with 35-39 years old mothers: a population study
- Lipopolysaccharide stimulation of 70 kilo Dalton heat shock protein messenger ribonucleic acid production in cultured human fetal membranes
- Effect of positive end expiratory pressure on functional residual capacity and compliance in surfactant-treated preterm infants
- Neonatal nucleated red blood cell counts in twins
- Normalisation of a severely abnormal ductus venosus Doppler flow velocity waveform in a growth-retarded fetus with absent end-diastolic flow in the umbilical artery and congenital anomalies
- Acute iliac vein thrombosis in pregnancy treated successfully by streptokinase lysis: a case report
- Liquid ventilation in an infant with persistent interstitial pulmonary emphysema
- Renal vein thrombosis in a newborn with prothrombotic genetic risk factors
- Fetal pulse oximetry allows safe continuation of labor in the presence of mild-moderate non reassuring CTG
- WAPM-Newsletter No 1
