Premature closure of foramen ovale and renal vein thrombosis in a stillborn twin homozygous for methylene tetrahydrofolate reductase gene polymorphism: A clinicopathologic case study
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Jerzy Stanek
Abstract
Premature closure of the foramen ovale, 4-chamber cardiac hypertrophy, and renal vein/vena cava thrombosis were found at autopsy of a stillborn dizygotic twin at 36 weeks gestational age. Review of the original prenatal sonograms showed features suggestive of early closure of the foramen ovale. Homozygosity for the 5,10 methylene tetrahydrofolate reductase mutation was shown only in the affected twin after the parents were found to be heterozygous for the mutation. The difference in outcome of the twins following prenatal treatment with beta mimetics and corticosteroids for preterm labor may be related to the added susceptibility factor for thromboembolism associated with presumed hyperhomocysteinemia in the proband which was not shared by the surviving healthy twin. The role of premature closure of the foramen ovale and prenatal treatment are discussed but remain uncertain.
Copyright (c)2000 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Inhaled nitric oxide in premature infants - a meta-analysis
- Fetal transverse cerebellar diameter in different ethnic groups
- Randomized trial of administration of prostaglandin E2 gel for induction of labor in the morning or the evening
- Fetal sciatic nerve growth is delayed following repeated maternal injections of corticosteroid in sheep
- Endoscopic examination of the fetus in early pregnancy
- The analysis of the complement activation product SC5 b-9 is applicable in neonates in spite of their profound C9 deficiency
- Perinatal factors and preterm delivery in an Irish obstetric population
- Relation between brain tissue pO2 and dopamine synthesis of basal ganglia - A 18FDOPA-PET study in newborn piglets
- Premature closure of foramen ovale and renal vein thrombosis in a stillborn twin homozygous for methylene tetrahydrofolate reductase gene polymorphism: A clinicopathologic case study
- Agenesis of the ductus venosus and its correlation to hydrops fetalis
