Identification of extrahepatic drug-metabolizing enzymes and their characterization by heterologous expression in mammalian cells

Articles in the same Issue

1. PREFACE
2. TABLE OF CONTENTS
3. Mechanisms for constitutive and developmental regulation of rat hepatic cytochrome P450 genes
4. Mechanisms of regulation of expression of hepatic cytochrome P450
5. Proteins involved in the regulation of the genes encoding the barbiturate-inducible P450s of rats and Bacillus megaterium
6. Regulation of glutathione S-transferase and quinone reductase gene expression by xenobiotics
7. Genetic and molecular analysis of the Ah receptor and of Cyp 1A1 gene expression
8. The Ah-receptor cDNA is a novel ligand activated transcription factor
9. Autoregulation plus negative and positive control of murine Cyp1a-1 gene expression and the [Ah]battery
10. Bacteria as a heterologous system for expression of steroid hydroxylases
11. Microsomal environment dependence of human P450 activities expressed in yeast
12. Expression of drug metabolizing enzymes in transgenic animals and heterologous expression systems
13. Stable expression of human cytochrome P450 cDNAs in human lymphoblastoid cells
14. Expression and characterization of human fetal liver cytochrome P450 (P450IIIA7)
15. The UDP-glucuronosyltransferase gene family: Function and expression of human UGTs
16. Structure and regulation of steroid UDP-glucuronosyltransferase genes
17. The novel UGT1 locus utilizes alternative transcriptional initiation and 25 differential splicing to encode human bilirubin, phenol and other UDP-glucuronosyltransferases with identical carboxyl termini
18. Primary structure and regulation of hepatic sulfotransferases
19. Regulation of gene expression of drug-metabolizing phase II enzymes
20. Cytochrome P450BM-3: A structural and functional model for microsomal cytochromes P450
21. An integrated picture of cytochrome P450 catalysis
22. Structure and function of the mitochondrial P450 system electron transfer proteins, adrenodoxin reductase and adrenodoxin
23. Correlation of the gene structures, three dimensional structures and functional properties of the glutathione S-transferases
24. The role of the peroxisome proliferator activated receptor in the induction of the rabbit CYP4A6 gene
25. Induction of P4501A1 by polycyclic aromatic compounds requires cooperation between Ah response elements and other sequence elements
26. Mechanisms of regulation of hormone- and substrate-dependent control of cytochrome P450 turnover
27. A transcription factor, Ad4BP, regulating all the steroidogenic P450 genes
28. The flavin-containing monooxygenase gene family
29. Ocular and renal cytochrome P450 arachidonic acid metabolism: Hormonal and pathological regulation
30. The arachidonic acid epoxygenase: A functional role for cytochrome P450 in the biosynthesis of novel lipid derived mediators
31. Regulation of P450-dependent hepatic steroid hydroxylation by growth hormone and thyroxine
32. Allene oxide synthesis: Novel reaction of cytochrome P450
33. Nitric oxide synthase functions as a catalytically self-sufficient cytochrome P450
34. Cytochrome P450lin(P450111): crystal unit cell, tertiary structure-function model
35. Structure and function of P450c21
36. Alteration of the substrate specificity of mouse 2A P450s by a mutation of residue-209: steroid-binding site and orientation
37. Role of the putative distal site in the catalytic function of cytochrome P4501A2
38. Composition of the NH2-terminal region governs the targeting of expressed P450 to Escherichia coli cytosol or membranes
39. Significance of phosphorylation of drug metabolizing enzymes for the control of carcinogenic metabolites
40. Protein adducts as index of metabolic activation and exposure to carcinogens
41. The role of cytochrome P4502E1 in chemically induced cytotoxicity
42. Metabolic activation of unsaturated derivatives of valproic acid: role of microsomal versus mitochondrial enzyme systems
43. Trace transition metal-catalyzed free radical reactions in microsomal drug metabolism
44. Genes involved in initiation and promotion in skin carcinogenesis
45. Genetic causes of interindividual and interethnic differences in drug metabolism
46. Genetic polymorphisms of drug-metabolizing enzymes in different populations
47. Roles in genetic polymorphisms of drug metabolizing enzymes in humans
48. Methyltransferase pharmacogenetics
49. Identification of extrahepatic drug-metabolizing enzymes and their characterization by heterologous expression in mammalian cells
50. Tyrphostins inhibit FSH and cAMP mediated functions in rat ovarian granulosa cells: Possible involvement of tyrosine phosphorylation
51. Prostate cytochrome P450
52. Biotransformation enzymes in olfactory signal termination
53. Modulation of P450 mediated estrogen metabolism by diet and its effect on hormone responsive target tissue tumors
54. The role of cytochrome P450 in the elimination of bilirubin in congenital jaundice (Crigler-Najjar Syndrome Type I)
55. Control of hyperbilirubinemia by use of heme oxygenase inhibitors
56. Therapeutic aspects of cytochrome P450 inhibition
57. Biochemistry of the steroid 5α-reductases and the physiological implications of inhibition
58. Common motifs in microsomal cytochrome P450 N-terminal membrane fragments
59. Inhibitor-induced conformational change in cytochrome P450cam
60. Metabolite predictions based on mechanisms of action and active site structures of cytochrome P450
61. Catalytic mechanisms of amine-N-dealkylation and N-oxygenation by cytochrome P450 enzymes
62. Modulators of stereoselective product formation in cytochrome P450cam S-oxidations
63. COMMUNICATIONS
64. POSTERS