Adrenaline: communication by electron emission. Effect of concentration and temperature. Product analysis
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Nikola Getoff
Abstract
Background: Based on the recent findings about the ability of sexual hormones to emit electrons (eaq–) and to act as electron mediator, it was of interest to investigate adrenaline as an important neurotransmitter.
Materials and methods: Highest purity adrenaline (ADR) and chemicals were used for preparation of aqueous solutions (pH ∼7.4). The excitation of ADR in singlet state was achieved by irradiation of airfree aqueous solution with monochromatic UV light at λ=254 nm. The emitted “solvated electrons” (eaq–) were scavenged by chloroethanol, where the quantum yield of Cl– ions, Q(Cl–)=Q(eaq–). ADR degradation and formation of photolytic products were followed by HPLC analysis.
Results and conclusion: It was found that Q(eaq–) values decrease with increasing ADR concentration: for 2.5×10–5 mol/L ADR was determined as Q(eaq–)=6×10–3, whereas for 1×10–3 mol/L ADR was found to be 0.9×10–3. This is explained by formation of associates in ground state, which consume a part of emitted eaq–. As a main photolytic product aminochrome was determined.
©2010 by Walter de Gruyter Berlin New York
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- Original articles
- Changes in mammary caveolin-1 signaling pathways are associated with breast cancer risk in rats exposed to estradiol in utero or during prepuberty
- Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells
- Congenital adrenal hyperplasia and the function of adrenal medulla
- Adrenaline: communication by electron emission. Effect of concentration and temperature. Product analysis
- Effect of trenbolone acetate plus estradiol on transcriptional regulation of metabolism pathways in bovine liver
- Effect of long-term topical application of dehydroepiandrosterone (DHEA) and oral estrogens on morphology, cell proliferation, procollagen A1 and androgen receptor levels in rat skin
