Article
Licensed
Unlicensed
Requires Authentication
Trefoil factor family peptides are increased in the saliva of children with mucositis
-
Fran Verey
Published/Copyright:
July 28, 2011
Abstract
Background: Mucositis is a painful ulcerative condition of the oral cavity and gastrointestinal tract, occurring in association with chemotherapy and radiotherapy regimes. Trefoil factor family peptides (TFF, trefoil peptides), present in saliva, contribute to epithelial restitution and repair and are therefore potentially important in the healing phase of mucositis. This study aimed to assess any changes in the levels of trefoil peptides in oncology patients with and without mucositis.
Methods: Saliva was collected from healthy children, pre-treatment oncology patients, neutropenic patients on treatment with no oral disease and mucositic patients. TFF1, 2 and 3 were quantified using ELISA.
Results: In healthy children TFF2 and 3 were positively correlated with age (ρ=0.454, p=0.01 for TFF2; ρ=0.410, p=0.05 for TFF3 Spearman rank correlation). TFF3 was higher in mucositis compared to all other groups. A linear regression prediction model indicated that TFF3, but not TFF1 and TFF2, was significantly different in mucositic and healthy controls, suggesting an altered pattern of trefoil peptide secretion (p=0.021).
Conclusions: This study is the first to focus on trefoil peptides in paediatric saliva. It shows the correlation between TFF2, TFF3 and age in healthy children. Paediatric mucositis disease occurs in the presence of increased concentrations and an altered pattern of trefoil peptides.
Received: 2011-4-13
Accepted: 2011-5-24
Published Online: 2011-7-28
Published in Print: 2011-12-1
©2011 by Walter de Gruyter Berlin Boston
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorial
- Appropriate labelling of blood collection tubes: a step ahead towards patient’s safety
- Reviews
- New insights into adipose tissue dysfunction in insulin resistance
- Role of biomarkers in cardioncology
- Minireviews
- Measurement of the pro-hormone of brain type natriuretic peptide (proBNP): methodological considerations and pathophysiological relevance
- High-sensitivity troponin assays in the evaluation of patients with acute chest pain in the emergency department
- Opinion Paper
- Regulation of in vitro diagnostics (IVDs) for use in clinical diagnostic laboratories: towards the light or dark in clinical laboratory testing?
- Guidelines and Recommendations
- The Greek way to the Register: the establishment and operation of the Register for Clinical Chemists-Clinical Biochemists in Greece
- Genetics and Molecular Diagnostics
- Rapid HLA-B27 screening with real-time TaqMan PCR: a clinical validation in the Dutch population
- General Clinical Chemistry and Laboratory Medicine
- Results of the recalibration of creatinine measurement with the modular Beckman Coulter® Jaffe creatinine method
- Heterophilic antibody interference in commercial immunoassays; a screening study using paired native and pre-blocked sera
- Oxidative status in the lungs associated with tobacco smoke exposure
- Correlation of cortisol in 1-cm hair segment with salivary cortisol in human: hair cortisol as an endogenous biomarker
- Evaluation of the MassTrak Immunosuppressant XE Kit for the determination of everolimus and cyclosporin A in human whole blood employing isotopically labeled internal standards
- Simultaneous determination of cyclophosphamide and 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry – application to Chinese systemic lupus erythematosus patients
- Sterol profiles in plasma and erythrocyte membranes in patients with Smith-Lemli-Opitz syndrome: a six-year experience
- Chemistry and haematology sample rejection and clinical impact in a tertiary laboratory in Cape Town
- Trefoil factor family peptides are increased in the saliva of children with mucositis
- Validation of commercial assays for measurements of trefoil factor family peptides in serum
- To mix or not to mix venous blood samples collected in vacuum tubes?
- Rapid and simple IgG specific test for the exclusion of heparin induced thrombocytopenia (HIT)
- β-Thalassemia mutations in subjects with borderline HbA2 values: a pilot study in North India
- Cancer Diagnostics
- Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers
- The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses
- Infectious Diseases
- Measurement of granulocyte maturation may improve the early diagnosis of the septic state
- Cardiovascular Diseases
- Influence of hemolysis on troponin testing: studies on Beckman Coulter UniCel Dxl 800 Accu-TnI and overview of the literature
- Methylenetetrahydrofolate reductase C677T polymorphism and congenital heart disease: a meta-analysis
- Determination of asymmetric dimethyl arginine in human serum by liquid chromatography-tandem mass spectrometry: clinical application in hypertensive subjects
- Diabetes
- The optimal cut-points of HbA1c for detecting newly diagnosed diabetes and pre-diabetes in the Chinese population living in Sichuan
- Letters to the Editor
- Specimen labelling: before or after collection?
- Effect of storage conditions and freeze/thaw cycles on aquaporin-4 antibody (NMO-IgG) serum levels
- Comparison of vancomycin concentrations in blood and interstitial fluid: a possible model for less invasive therapeutic drug monitoring
- Acknowledgement
- Acknowledgement
Keywords for this article
ELISA;
healthy children;
neutropenia;
oral mucositis;
saliva;
trefoil peptides
Articles in the same Issue
- Editorial
- Appropriate labelling of blood collection tubes: a step ahead towards patient’s safety
- Reviews
- New insights into adipose tissue dysfunction in insulin resistance
- Role of biomarkers in cardioncology
- Minireviews
- Measurement of the pro-hormone of brain type natriuretic peptide (proBNP): methodological considerations and pathophysiological relevance
- High-sensitivity troponin assays in the evaluation of patients with acute chest pain in the emergency department
- Opinion Paper
- Regulation of in vitro diagnostics (IVDs) for use in clinical diagnostic laboratories: towards the light or dark in clinical laboratory testing?
- Guidelines and Recommendations
- The Greek way to the Register: the establishment and operation of the Register for Clinical Chemists-Clinical Biochemists in Greece
- Genetics and Molecular Diagnostics
- Rapid HLA-B27 screening with real-time TaqMan PCR: a clinical validation in the Dutch population
- General Clinical Chemistry and Laboratory Medicine
- Results of the recalibration of creatinine measurement with the modular Beckman Coulter® Jaffe creatinine method
- Heterophilic antibody interference in commercial immunoassays; a screening study using paired native and pre-blocked sera
- Oxidative status in the lungs associated with tobacco smoke exposure
- Correlation of cortisol in 1-cm hair segment with salivary cortisol in human: hair cortisol as an endogenous biomarker
- Evaluation of the MassTrak Immunosuppressant XE Kit for the determination of everolimus and cyclosporin A in human whole blood employing isotopically labeled internal standards
- Simultaneous determination of cyclophosphamide and 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry – application to Chinese systemic lupus erythematosus patients
- Sterol profiles in plasma and erythrocyte membranes in patients with Smith-Lemli-Opitz syndrome: a six-year experience
- Chemistry and haematology sample rejection and clinical impact in a tertiary laboratory in Cape Town
- Trefoil factor family peptides are increased in the saliva of children with mucositis
- Validation of commercial assays for measurements of trefoil factor family peptides in serum
- To mix or not to mix venous blood samples collected in vacuum tubes?
- Rapid and simple IgG specific test for the exclusion of heparin induced thrombocytopenia (HIT)
- β-Thalassemia mutations in subjects with borderline HbA2 values: a pilot study in North India
- Cancer Diagnostics
- Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers
- The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses
- Infectious Diseases
- Measurement of granulocyte maturation may improve the early diagnosis of the septic state
- Cardiovascular Diseases
- Influence of hemolysis on troponin testing: studies on Beckman Coulter UniCel Dxl 800 Accu-TnI and overview of the literature
- Methylenetetrahydrofolate reductase C677T polymorphism and congenital heart disease: a meta-analysis
- Determination of asymmetric dimethyl arginine in human serum by liquid chromatography-tandem mass spectrometry: clinical application in hypertensive subjects
- Diabetes
- The optimal cut-points of HbA1c for detecting newly diagnosed diabetes and pre-diabetes in the Chinese population living in Sichuan
- Letters to the Editor
- Specimen labelling: before or after collection?
- Effect of storage conditions and freeze/thaw cycles on aquaporin-4 antibody (NMO-IgG) serum levels
- Comparison of vancomycin concentrations in blood and interstitial fluid: a possible model for less invasive therapeutic drug monitoring
- Acknowledgement
- Acknowledgement
