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Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease
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Chih-Chia Chang
Published/Copyright:
June 17, 2011
Abstract
Background: Pentraxin 3 (PTX3) plays an important role in innate immune responses and in inflammation disease. The aim of this study was to investigate the diagnostic and prognostic potential of PTX3 in pelvic inflammatory disease (PID) and correlate it with the severity and outcome of PID.
Methods: Blood specimens were collected from 64 patients with PID before and after treatment and 70 healthy controls and the plasma levels of PTX3 were measured using enzyme-linked immunosorbent assay (ELISA) kits.
Results: It was found that the plasma level of PTX3 expression was elevated in PID patients compared with healthy controls and decreased significantly after they received treatment. When the cut-off level of plasma PTX3 was set at 2.87 ng/mL, PTX3 had higher sensitivity (84.38%) and lower false-negative rate (15.63%) than CRP (79.69% and 20.31%, respectively) in predicting PID. The level of PTX3 also exhibited a significant correlation with length of hospital stay (r=0.581, p<0.001).
Conclusions: Plasma PTX3 concentration not only predicts the presence of PID with lower false-negative rate than CRP, but plasma PTX3 concentration is also affiliated with the presence of tubo-ovarian abscess (TOA) and the length of hospital stay.
Keywords: false-negative rate; length of hospital stay; pelvic inflammatory disease; pentraxin 3; sensitivity; tubo-ovarian abscess
Received: 2011-3-6
Accepted: 2011-5-12
Published Online: 2011-06-17
Published in Print: 2011-10-01
©2011 by Walter de Gruyter Berlin Boston
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Keywords for this article
false-negative rate;
length of hospital stay;
pelvic inflammatory disease;
pentraxin 3;
sensitivity;
tubo-ovarian abscess
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- Editorial
- Laboratory medicine: an essential partner in the care of cancer patients
- Reviews
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