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Genetics of infectious diseases: hidden etiologies and common pathways
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Marianna Orlova
Published/Copyright:
May 27, 2011
Abstract
Since the completion of the human genome sequence, the study of common genetic polymorphisms in complex human diseases has become a main activity of human genetics. Employing genome-wide association studies, hundreds of modest genetic risk factors have been identified. In infectious diseases the identification of common risk factors has been varied and as in other common diseases it seems likely that important genetic risk factors remain to be discovered. Nevertheless, the identification of disease-specific genetic risk factors revealed an unexpected overlap in susceptibility genes of diverse inflammatory and infectious diseases. Analysis of the multi-disease susceptibility genes has allowed the definition of shared key pathways of inflammatory dysregulation and suggested unexpected infectious etiologies for other “non-infectious” common diseases.
Keywords: common variant hypothesis; genome-wide association studies; infectious diseases; rare variants
Received: 2011-3-15
Accepted: 2011-4-26
Published Online: 2011-05-27
Published in Print: 2011-09-01
©2011 by Walter de Gruyter Berlin Boston
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Keywords for this article
common variant hypothesis;
genome-wide association studies;
infectious diseases;
rare variants
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