Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
Low-density lipoprotein receptor-related protein 1: new functions for an old molecule
-
Massimo Franchini
und
Martina Montagnana
Veröffentlicht/Copyright:
11. März 2011
Abstract
The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor member of the low-density lipoprotein (LDL)-receptor family. As LRP1 plays an important role in endocytosis and regulation of signalling pathways, it is implicated in a number of physiologic processes, including the regulation of lipid metabolism, the proliferation of vascular smooth muscle cells and in neuro-development. More recently, LRP1 has been implicated in the catabolism of factor VIII and regulation of its plasma concentrations. The pathophysiology of the role of LRP1 in hemostasis will be summarized in this review.
Keywords: endocytosis; factor VIII (FVIII); lipoprotein receptor-related protein 1 (LRP1); thrombosis
Received: 2010-12-9
Accepted: 2010-12-29
Published Online: 2011-03-11
Published in Print: 2011-06-01
©2011 by Walter de Gruyter Berlin Boston
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- Editors’ and Publisher’s Note
- CCLM Award for The Most Cited Paper Recently Published
- Reviews
- Some views on proteomics in diabetes
- Cancer biomarkers for hepatocellular carcinomas: from traditional markers to recent topics
- Minireviews
- Low-density lipoprotein receptor-related protein 1: new functions for an old molecule
- Could serum measurements of S100 proteins be reliable markers to predict recurrence in meningiomas?
- Opinion Paper
- Focusing on the clinical impact of standardization of creatinine measurements: a report by the EFCC Working Group on Creatinine Standardization
- General Clinical Chemistry and Laboratory Medicine
- Use of a fully automated immunoassay for celiac disease screening in a pediatric population
- Evaluation of four commercial biuret reagent kits of serum total protein by the American Association for Clinical Chemistry reference measurement procedure
- Renal function parameters during early and late recovery periods following an all-out 21-km run in trained adolescent runners
- Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia
- The severity of pseudohyperkalaemia is not dependent upon the stage of chronic kidney disease: a prospective study
- Modified phosphatidylserine-dependent antithrombin ELISA enables identification of patients negative for other antiphospholipid antibodies and also detects low avidity antibodies
- Perchlorate (Irenat®) may falsely lower measured ionised calcium
- Comparison of thyroglobulin antibody interference in first- and second-generation thyroglobulin immunoassays
- A case of consistent discrepancies between urine and blood human chorionic gonadotropin measurements
- Reference Values and Biological Variations
- Reference change values for monitoring dehydration
- Cancer Diagnostics
- Diagnostic value of pro-gastrin-releasing peptide for small cell lung cancer: a meta-analysis
- Plasma concentrations of angiogenetic factors and angiogenetic inhibitors in patients with ductal pancreatic neoplasms. A pilot study
- Cardiovascular Diseases
- High-sensitivity troponin T improves the prognostic value of N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: results from the LURIC Study
- Letters to the Editor
- Results of a pilot external quality assessment study on free protoporphyrin in erythrocytes
- Trueness assessment of Korean nation-wide glucose proficiency testing
- Genetic polymorphism of cytochrome P450 1A1 in a northern Italian population: high frequency of the CYP1A1*2C allele
- Prestaining of PCR products with SYBR Green for agarose gel electrophoresis: advantages and limitations
- A bias in quantitative RT-PCR limit of detection is induced by the use of cancer cell lines in the molecular detection of circulating tumor cells
- Treatment of hepatitis B virus-associated membranous nephritis patients in Chinese: an open parallel controlled trial
- Evidence on the cause of false positive troponin I results with the Beckman AccuTnI method
- Cross-reactivity of insulin analogs with the Diasorin Liaison Insulin assay
- Improved turnaround time for neonatal hematology profile tests (complete blood count) using a new microcollection tube
- Erratum
- Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes
Schlagwörter für diesen Artikel
endocytosis;
factor VIII (FVIII);
lipoprotein receptor-related protein 1 (LRP1);
thrombosis
Artikel in diesem Heft
- Editors’ and Publisher’s Note
- CCLM Award for The Most Cited Paper Recently Published
- Reviews
- Some views on proteomics in diabetes
- Cancer biomarkers for hepatocellular carcinomas: from traditional markers to recent topics
- Minireviews
- Low-density lipoprotein receptor-related protein 1: new functions for an old molecule
- Could serum measurements of S100 proteins be reliable markers to predict recurrence in meningiomas?
- Opinion Paper
- Focusing on the clinical impact of standardization of creatinine measurements: a report by the EFCC Working Group on Creatinine Standardization
- General Clinical Chemistry and Laboratory Medicine
- Use of a fully automated immunoassay for celiac disease screening in a pediatric population
- Evaluation of four commercial biuret reagent kits of serum total protein by the American Association for Clinical Chemistry reference measurement procedure
- Renal function parameters during early and late recovery periods following an all-out 21-km run in trained adolescent runners
- Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia
- The severity of pseudohyperkalaemia is not dependent upon the stage of chronic kidney disease: a prospective study
- Modified phosphatidylserine-dependent antithrombin ELISA enables identification of patients negative for other antiphospholipid antibodies and also detects low avidity antibodies
- Perchlorate (Irenat®) may falsely lower measured ionised calcium
- Comparison of thyroglobulin antibody interference in first- and second-generation thyroglobulin immunoassays
- A case of consistent discrepancies between urine and blood human chorionic gonadotropin measurements
- Reference Values and Biological Variations
- Reference change values for monitoring dehydration
- Cancer Diagnostics
- Diagnostic value of pro-gastrin-releasing peptide for small cell lung cancer: a meta-analysis
- Plasma concentrations of angiogenetic factors and angiogenetic inhibitors in patients with ductal pancreatic neoplasms. A pilot study
- Cardiovascular Diseases
- High-sensitivity troponin T improves the prognostic value of N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: results from the LURIC Study
- Letters to the Editor
- Results of a pilot external quality assessment study on free protoporphyrin in erythrocytes
- Trueness assessment of Korean nation-wide glucose proficiency testing
- Genetic polymorphism of cytochrome P450 1A1 in a northern Italian population: high frequency of the CYP1A1*2C allele
- Prestaining of PCR products with SYBR Green for agarose gel electrophoresis: advantages and limitations
- A bias in quantitative RT-PCR limit of detection is induced by the use of cancer cell lines in the molecular detection of circulating tumor cells
- Treatment of hepatitis B virus-associated membranous nephritis patients in Chinese: an open parallel controlled trial
- Evidence on the cause of false positive troponin I results with the Beckman AccuTnI method
- Cross-reactivity of insulin analogs with the Diasorin Liaison Insulin assay
- Improved turnaround time for neonatal hematology profile tests (complete blood count) using a new microcollection tube
- Erratum
- Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes
