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Current state and future directions of neurochemical biomarkers for Alzheimer's disease
Veröffentlicht/Copyright:
1. November 2007
Abstract
In this comprehensive review, we summarize the current state-of-the-art of neurochemical biomarkers for Alzheimer's disease. Predominantly, these biomarkers comprise cerebrospinal fluid biomarkers directly related to the pathophysiology of this disorder (such as amyloid β protein, tau protein). We particularly pay attention to the innovations in this area that have been made in technological aspects during the past 5 years (e.g., multiplex analysis of biomarkers, proteomics), to the discovery of novel, potential biomarkers (e.g., amyloid β oligomers, isoprostanes), and to the extension of this research towards identification of biomarkers in plasma.
Clin Chem Lab Med 2007;45:1421–34.
Keywords: Alzheimer's disease; amyloid β protein; biological markers; cerebrospinal fluid; tau proteins
Received: 2007-6-7
Accepted: 2007-8-28
Published Online: 2007-11-01
Published in Print: 2007-11-01
©2007 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
Alzheimer's disease;
amyloid β protein;
biological markers;
cerebrospinal fluid;
tau proteins
Artikel in diesem Heft
- Current state and future directions of neurochemical biomarkers for Alzheimer's disease
- Use of SELDI-TOF mass spectrometry for identification of new biomarkers: potential and limitations
- Analysis of ferritin genes in Parkinson disease
- Multimers and adiponectin gene 276G>T polymorphism in the Japanese population residing in rural areas
- Evaluation of genus-specific and species-specific real-time PCR assays for the identification of Brucella spp.
- A polymorphism in the resistin gene promoter is related to increased C-reactive protein levels in patients with coronary artery disease
- Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with myocardial infarction in Tunisian patients
- How useful are housekeeping genes? Variable expression in melanoma metastases
- Combined androgen blockade therapy can convert RT-PCR detection of prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) transcripts from positive to negative in the peripheral blood of patients with clinically localized prostate cancer and increase biochemical failure-free survival after curative therapy
- Isobutyryl-CoA dehydrogenase deficiency with a novel ACAD8 gene mutation detected by tandem mass spectrometry newborn screening
- Circulating levels of osteoprotegerin and receptor activator of NF-κB ligand in patients with chronic renal failure
- Altered angiogenesis in preeclampsia: evaluation of a new test system for measuring placental growth factor
- Impact of rosiglitazone on the expression of β3-AR in the stable cell lines expressed β3-AR gene
- Biochemical and hormonal composition, cytological examination of thyroid cyst fluid, and comparison according to gender and color of cyst fluid
- Redefining functional sensitivity of thyroglobulin assay on Immulite platform: implications in thyroid cancer management
- Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age
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- Increased serum S100B protein in chronic schizophrenic patients in Korea
- Addendum to the recent report of EC4 on the accreditation of medical laboratories in the European Union
- Reply to the letter written by Haeckel
- The systemic inflammatory response syndrome C-reactive protein and transthyretin conundrum
- Transthyretin, nutrition, and inflammation: response to Dr. Bernstein
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