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Point-of-care creatinine testing in children at risk for sudden deterioration of renal function
Published/Copyright:
October 31, 2007
Abstract
Background: Point-of-care testing for creatinine blood concentrations may be useful in predicting the onset of recurrent conditions threatening renal function in children at home. Our aim was to evaluate two point-of-care systems for creatinine testing vs. an automated creatinine assay.
Methods: Twenty patients aged between 2 months and 17 years were randomly selected. Capillary blood specimens were taken for two point-of-care tests (Reflotron and i-STAT), and the results were compared to the routine enzymatic creatinine assay on a Hitachi 912 analyser using material collected simultaneously.
Results: The mean difference in creatinine concentration between the Reflotron and the Hitachi 912 and i-STAT and Hitachi 912 test was –16 and 4 μmol/L, respectively. The slope of the Passing-Bablok method comparison was 0.95 (95% CI 0.87–1.06) and 0.96 (95% CI 0.90–1.00) for the Reflotron and i-STAT test, respectively.
Conclusions: The blood creatinine concentrations measured using the Reflotron and the i-STAT device correlated well with those from the routine assay, especially in the concentration range up to 500 μmol/L. Both systems are good options for point-of-care creatinine testing in capillary blood. However, the i-STAT seems the better option for monitoring at home given its greater ease of use.
Clin Chem Lab Med 2007;45:1536–41.
Keywords: child; creatinine; haemolytic-uremic syndrome; physiological monitoring; point-of-care systems
Received: 2007-5-10
Accepted: 2007-7-23
Published Online: 2007-10-31
Published in Print: 2007-11-01
©2007 by Walter de Gruyter Berlin New York
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Keywords for this article
child;
creatinine;
haemolytic-uremic syndrome;
physiological monitoring;
point-of-care systems
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