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Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens
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Brian J. Morris
Veröffentlicht/Copyright:
7. Mai 2007
Abstract
Cervical screening by Pap smear involves a high rate of false negatives, necessitating frequent testing. Because women do not like the sampling procedure, many avoid being screened. Testing for the causative high-risk human papillomavirus (HPV) types, by PCR or other technologies, on self-collected (tampon) samples permits women to be monitored non-invasively. The high negative predictive value of HPV testing means a greater interval between tests, and thus reduces costs. HPV testing lends itself to primary screening. A kit for self-collection and return to a testing laboratory, followed by practitioner notification and follow-up if required, should result in wider participation. The higher accuracy of HPV testing should lead to improved cervical cancer prevention.
Clin Chem Lab Med 2007;45:577–91.
Keywords: cervical cancer; cervical screening; human papillomavirus; hybrid capture; polymerase chain reaction; specimen self-collection; tampon
Received: 2006-12-15
Accepted: 2007-2-25
Published Online: 2007-05-07
Published in Print: 2007-05-01
©2007 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
cervical cancer;
cervical screening;
human papillomavirus;
hybrid capture;
polymerase chain reaction;
specimen self-collection;
tampon
Artikel in diesem Heft
- 6th Conference on Homocysteine Metabolism, World Congress on Hyperhomocysteinemia, Saarbruecken/Germany June 5-9, 2007
- The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes
- Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens
- Influence of apolipoprotein E polymorphism on serum lipid and lipoprotein changes: a 21-year follow-up study from childhood to adulthood. The Cardiovascular Risk in Young Finns Study
- Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels
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