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Prevalence of abnormal thyroid stimulating hormone and thyroid peroxidase antibody-positive results in a population of pregnant women in the Samara region of the Russian Federation

  • Frank A. Quinn , Gennady N. Gridasov , Sergey A. Vdovenko , Natalia A. Krasnova , Nadezhda V. Vodopianova , Marina A. Epiphanova and Monika Schulten
Published/Copyright: October 19, 2005
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 43 Issue 11

Abstract

Undiagnosed thyroid disease is a common problem with significant public health implications. This is especially true during pregnancy, when the health of both the mother and the developing child can be adversely affected by abnormal maternal thyroid function. Measurement of serum thyroid stimulating hormone (TSH) and thyroid peroxidase antibodies (TPO-Ab) are two common ways to assess maternal thyroid status. The objective of our study was to determine the prevalence of abnormal TSH and TPO-Ab tests in a population of pregnant women in the Samara region of the Russian Federation. Serum samples were obtained from 1588 pregnant women as part of their routine antenatal care. TSH and TPO-Ab were measured, and trimester-specific reference values for TSH (2.5–97.5 percentiles) were calculated using TPO-Ab-negative women. TSH results outside these ranges were considered abnormal; TPO-Ab levels outside the manufacturer's reference range (>12IU/mL) were considered abnormal. Overall, the prevalence of abnormal results was 6.3% for TSH and 10.7% for TPO-Ab. High TSH (>97.5 trimester-specific percentile) and TPO-Ab-positive results were most common in the first trimester (5.7% and 13.8%, respectively). TSH levels were associated with gestational age and TPO-Ab status, and with maternal age in TPO-Ab-negative women. TPO-Ab status was associated with both maternal and gestational age. Women with TSH >2.5mIU/L had a significantly increased risk of being TPO-Ab-positive, and this risk increased with age. Based on our data, we conclude that abnormal TSH and TPO-Ab are common in pregnant women of the Samara region. Given the association of thyroid dysfunction to adverse pregnancy outcomes, screening of this population for abnormal thyroid function should be considered.

Keywords: pregnancy; prevalence; thyroid dysfunction
Corresponding author: Frank A. Quinn, Abbott Laboratories, Abbott Park, IL, USA

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Received: 2005-6-2
Accepted: 2005-8-16
Published Online: 2005-10-19
Published in Print: 2005-11-1

©2005 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2005.212
Keywords for this article
pregnancy; prevalence; thyroid dysfunction

Articles in the same Issue

  1. Cervical human papillomavirus screening by PCR: advantages of targeting the E6/E7 region
  2. Isotretinoin therapy induces DNA oxidative damage
  3. Structural evaluation of plasma α2-macroglobulin in acute pancreatitis
  4. Failure of the PAXgene™ Blood RNA System to maintain mRNA stability in whole blood
  5. Reticulocyte hemoglobin measurement – comparison of two methods in the diagnosis of iron-restricted erythropoiesis
  6. Physical analysis of ejaculate to evaluate the secretory activity of the seminal vesicles and prostate
  7. Specificity of the 3H-triolein assay for pancreatic lipase in blood plasma
  8. Effects of hemolysis and storage condition on neuron-specific enolase (NSE) in cerebrospinal fluid and serum: implications in clinical practice
  9. Plasma levels of 7-hydroxymetabolites of dehydroepiandrosterone in healthy Central European aging men
  10. Prevalence of abnormal thyroid stimulating hormone and thyroid peroxidase antibody-positive results in a population of pregnant women in the Samara region of the Russian Federation
  11. Impact of standardized calibration on the inter-assay variation of 14 automated assays for the measurement of creatinine in human serum
  12. Efficacy of three ELISA measurements of anti-cyclic citrullinated peptide antibodies in the early diagnosis of rheumatoid arthritis
  13. Mean and variance quality control for multiple correlated levels of replicated control samples
  14. Clinical evaluation of serodiagnosis of active tuberculosis by multiple-antigen ELISA using lipids from Mycobacterium bovis BCG Tokyo 172
  15. Analytical evaluation of the Dade Behring Dimension RxL automated N-Terminal proBNP (NT-proBNP) method and comparison with the Roche Elecsys 2010
  16. Unusually high alkaline phosphatase due to intestinal isoenzyme in a healthy adult
  17. Deficient α-galactosidase A activity in plasma but no Fabry disease – a pitfall in diagnosis
  18. Reportable interval of patient examination results and ISO 15189
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