Differential production of immunoglobulin classes and subclasses by mucosal-type human B-lymphocytes exposed in vitro to CpG oligodeoxynucleotides

References

1 Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973–83. 10.1016/S0092-8674(00)80172-5Search in Google Scholar

2 Imler JL, Hoffmann JA. Signaling mechanisms in the antimicrobial host defense of Drosophila. Curr Opin Microbiol 2000; 3: 16–22. 10.1016/S1369-5274(99)00045-4Search in Google Scholar

3 Gordon S. Pattern recognition receptors: doubling up for the innate immune response. Cell 2002; 111: 927–30. 10.1016/S0092-8674(02)01201-1Search in Google Scholar

4 Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 394–7. 10.1038/41131Search in Google Scholar

5 Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499–511. 10.1038/nri1391Search in Google Scholar

6 Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, et al. A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004; 303: 1522–6. 10.1126/science.1094351Search in Google Scholar

7 Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002; 20: 709–60. 10.1146/annurev.immunol.20.100301.064842Search in Google Scholar

8 O'Neill LA. Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal? Trends Immunol 2002; 23: 296–300. 10.1016/S1471-4906(02)02222-6Search in Google Scholar

9 Gugasyan R, Grumont R, Grossmann M, Nakamura Y, Pohl T, Nesic D, et al. Rel/NF-kappaB transcription factors: key mediators of B-cell activation. Immunol Rev 2000; 176: 134–40. 10.1034/j.1600-065X.2000.00615.xSearch in Google Scholar PubMed

10 Lipford GB, Sparwasser T, Bauer M, Zimmermann S, Koch ES, Heeg K, et al. Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur J Immunol 1997; 27: 3420–6. 10.1002/eji.1830271242Search in Google Scholar PubMed

11 Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 1997; 186: 1623–31. 10.1084/jem.186.10.1623Search in Google Scholar

12 Bauer S, Kirschning CJ, Hacker H, Redecke V, Hausmann S, Akira S, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 2001; 98: 9237–42. 10.1073/pnas.161293498Search in Google Scholar

13 Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 740–5. 10.1038/35047123Search in Google Scholar

14 Shirota H, Sano K, Hirasawa N, Terui T, Ohuchi K, Hattori T, et al. Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells. J Immunol 2001; 167: 66–74. 10.4049/jimmunol.167.1.66Search in Google Scholar

15 Ban E, Dupre L, Hermann E, Rohn W, Vendeville C, Quatannens B, et al. CpG motifs induce Langerhans cell migration in vivo. Int Immunol 2000; 12: 737–45. 10.1093/intimm/12.6.737Search in Google Scholar

16 Warren TL, Bhatia SK, Acosta AM, Dahle CE, Ratliff TL, Krieg AM, et al. APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells. J Immunol 2000; 165: 6244–51. 10.4049/jimmunol.165.11.6244Search in Google Scholar

17 Jarrossay D, Napolitani G, Colonna M, Sallusto F, Lanzavecchia A. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001; 31: 3388–93. 10.1002/1521-4141(200111)31:11<3388::AID-IMMU3388>3.0.CO;2-QSearch in Google Scholar

18 Sparwasser T, Vabulas RM, Villmow B, Lipford GB, Wagner H. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur J Immunol 2000; 30: 3591–7. 10.1002/1521-4141(200012)30:12<3591::AID-IMMU3591>3.0.CO;2-JSearch in Google Scholar

19 Bauer M, Redecke V, Ellwart JW, Scherer B, Kremer JP, Wagner H, et al. Bacterial CpG-DNA triggers activation and maturation of human CD11c–, CD123+ dendritic cells. J Immunol 2001; 166: 5000–7. 10.4049/jimmunol.166.8.5000Search in Google Scholar

20 Kadowaki N, Antonenko S, Liu YJ. Distinct CpG DNA and polyinosinic–polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN. J Immunol 2001; 166: 2291–5. 10.4049/jimmunol.166.4.2291Search in Google Scholar

21 Krug A, Towarowski A, Britsch S, Rothenfusser S, Hornung V, Bals R, et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 2001; 31: 3026–37. 10.1002/1521-4141(2001010)31:10<3026::AID-IMMU3026>3.0.CO;2-HSearch in Google Scholar

22 Bourke E, Bosisio D, Golay J, Polentarutti N, Mantovani A. The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 2003; 102: 956–63. 10.1182/blood-2002-11-3355Search in Google Scholar

23 Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001; 194: 863–9. 10.1084/jem.194.6.863Search in Google Scholar

24 Verthelyi D, Klinman DM. Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates. Clin Immunol 2003; 109: 64–71. 10.1016/S1521-6616(03)00202-XSearch in Google Scholar

25 Verthelyi D, Zeuner RA. Differential signaling by CpG DNA in DCs and B cells: not just TLR9. Trends Immunol 2003; 24: 519–22. 10.1016/S1471-4906(03)00243-6Search in Google Scholar

26 Gursel M, Verthelyi D, Gursel I, Ishii KJ, Klinman DM. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide. J Leukoc Biol 2002; 71: 813–20. 10.1189/jlb.71.5.813Search in Google Scholar

27 Decker T, Schneller F, Sparwasser T, Tretter T, Lipford GB, Wagner H, et al. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 2000; 95: 999–1006. 10.1182/blood.V95.3.999.003k10_999_1006Search in Google Scholar

28 Decker T, Schneller F, Kronschnabl M, Dechow T, Lipford GB, Wagner H, et al. Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: costimulation with IL-2 results in a highly immunogenic phenotype. Exp Hematol 2000; 28: 558–68. 10.1016/S0301-472X(00)00144-2Search in Google Scholar

29 Jung J, Yi AK, Zhang X, Choe J, Li L, Choi YS. Distinct response of human B cell subpopulations in recognition of an innate immune signal, CpG DNA. J Immunol 2002; 169: 2368–73. 10.4049/jimmunol.169.5.2368Search in Google Scholar

30 Rothenfusser S, Tuma E, Wagner M, Endres S, Hartmann G. Recent advances in immunostimulatory CpG oligonucleotides. Curr Opin Mol Ther 2003; 5: 98–106. Search in Google Scholar

31 Bouharoun-Tayoun H, Druilhe P. Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity. Infect Immun 1992; 60: 1473–81. 10.1128/iai.60.4.1473-1481.1992Search in Google Scholar

32 Taylor RR, Allen SJ, Greenwood BM, Riley EM. IgG3 antibodies to Plasmodium falciparum merozoite surface protein 2 (MSP2): increasing prevalence with age and association with clinical immunity to malaria. Am J Trop Med Hyg 1998; 58: 406–13. 10.4269/ajtmh.1998.58.406Search in Google Scholar

33 Garraud O, Perraut R, Riveau G, Nutman TB. Class and subclass selection in parasite-specific antibody responses. Trends Parasitol 2003; 19: 300–4. 10.1016/S1471-4922(03)00139-9Search in Google Scholar

34 Garraud O, Mahanty S, Perraut R. Malaria-specific antibody subclasses in immune individuals: a key source of information for vaccine design. Trends Immunol 2003; 24: 30–5. 10.1016/S1471-4906(02)00012-1Search in Google Scholar

35 Laichalk LL, Hochberg D, Babcock GJ, Freeman RB, Thorley-Lawson DA. The dispersal of mucosal memory B cells: evidence from persistent EBV infection. Immunity 2002; 16: 745–54. 10.1016/S1074-7613(02)00318-7Search in Google Scholar

36 Cognasse F, Beniguel L, El HR, Sabido O, Chavarin P, Genin C, et al. HIV-gp160 modulates differentially the production in vitro of IgG, IgA and cytokines by blood and tonsil B lymphocytes from HIV-negative individuals. Clin Exp Immunol 2003; 132: 304–8. 10.1046/j.1365-2249.2003.02152.xSearch in Google Scholar

37 Senez B, Laugier J. [Indications for adenoidectomy and/or tonsillectomy in children. Work Group assembled by the National Agency for Health Accreditation and Evaluation (ANAES)]. Ann Otolaryngol Chir Cervicofac 1998; 115(Suppl 1): S22–45. Search in Google Scholar

38 Garraud O, Diouf A, Nguer CM, Tall A, Marrama L, Perraut R. Experimental IgG antibody production in vitro by peripheral blood and tonsil surface gamma+ B lymphocytes from Plasmodium falciparum-immune West Africans. Scand J Immunol 2001; 54: 606–12. 10.1046/j.1365-3083.2001.01011.xSearch in Google Scholar

39 Cognasse F, Sabido O, Beniguel L, Genin C, Garraud O. A flow cytometry technique to study nuclear factor-kappa (NF-κ)B translocation during human B cell activation. Immunol Lett 2003; 9: 49–52. 10.1016/S0165-2478(03)00173-1Search in Google Scholar

40 Bohle B, Orel L, Kraft D, Ebner C. Oligodeoxynucleotides containing CpG motifs induce low levels of TNF-alpha in human B lymphocytes: possible adjuvants for Th1 responses. J Immunol 2001; 166: 3743–8. 10.4049/jimmunol.166.6.3743Search in Google Scholar

41 Verthelyi D, Ishii K, Gursel M, Takeshita F, Klinman D. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J Immunol 2001; 166: 2372–7. 10.4049/jimmunol.166.4.2372Search in Google Scholar

42 Banchereau J, Dubois B, Fayette J, Burdin N, Briere F, Miossec P, et al. Functional CD40 antigen on B cells, dendritic cells and fibroblasts. Adv Exp Med Biol 1995; 378: 79–83. 10.1007/978-1-4615-1971-3_16Search in Google Scholar

43 Burdin N, van Kooten C, Galibert L, Abrams JS, Wijdenes J, Banchereau J, et al. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J Immunol 1995; 154: 2533–44. 10.4049/jimmunol.154.6.2533Search in Google Scholar

44 Hirano T, Yonekubo I, Shimo K, Mizuguchi J. CD27 synergizes with CD40 to induce IgM, IgG, and IgA antibody responses of peripheral blood B cells in the presence of IL-2 and IL-10. Immunol Lett 2003; 89: 251–7. 10.1016/S0165-2478(03)00156-1Search in Google Scholar

45 Garraud O, Nkenfou C, Bradley JE, Perler FB, Nutman TB. Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies. J Immunol 1995; 155: 1316–25. 10.4049/jimmunol.155.3.1316Search in Google Scholar

46 Garraud O, Nutman T. The roles of cytokines on human B cell differentiation into immunoglobulin secreting cells. Bull Inst Pasteur 1993; 94: 285–309. 10.1016/S0020-2452(97)87084-4Search in Google Scholar

47 Pistoia V. Production of cytokines by human B cells in health and disease. Immunol Today 1997; 18: 343–50. 10.1016/S0167-5699(97)01080-3Search in Google Scholar

48 Roy MP, Kim CH, Butcher EC. Cytokine control of memory B cell homing machinery. J Immunol 2002; 169: 1676–82. 10.4049/jimmunol.169.4.1676Search in Google Scholar

49 Garraud O, Nkenfou C, Bradley JE, Nutman TB. Differential regulation of antigen-specific IgG4 and IgE antibodies in response to recombinant filarial proteins. Int Immunol 1996; 8: 1841–8. 10.1093/intimm/8.12.1841Search in Google Scholar

50 Garraud O, Mollis SN, Holland SM, Sneller MC, Malech HL, Gallin JI, et al. Regulation of immunoglobulin production in hyper-IgE (Job's) syndrome. J Allergy Clin Immunol 1999; 103: 333–40. 10.1016/S0091-6749(99)70510-5Search in Google Scholar

51 Garraud O, Diouf A, Holm I, Nguer CM, Spiegel A, Perraut R, et al. Secretion of parasite-specific immunoglobulin G by purified blood B lymphocytes from immune individuals after in vitro stimulation with recombinant Plasmodium falciparum merozoite surface protein-119 antigen. Immunology 1999; 97: 204–10. 10.1046/j.1365-2567.1999.00763.xSearch in Google Scholar PubMed PubMed Central

52 Garraud O, Diouf A, Holm I, Perraut R, Longacre S. Immune responses to Plasmodium falciparum-merozoite surface protein 1 (MSP1) antigen, II. Induction of parasite-specific immunoglobulin G in unsensitized human B cells after in vitro T-cell priming with MSP119. Immunology 1999; 97: 497–505. 10.1046/j.1365-2567.1999.00804.xSearch in Google Scholar PubMed PubMed Central

53 Porakishvili N, Mageed R, Jamin C, Pers JO, Kulikova N, Renaudineau Y, et al. Recent progress in the understanding of B-cell functions in autoimmunity. Scand J Immunol 2001; 54: 30–8. 10.1046/j.1365-3083.2001.00950.xSearch in Google Scholar PubMed

54 Garraud O, Diouf A, Nguer CM, Dieye A, Longacre S, Kaslow DC, et al. Different Plasmodium falciparum recombinant MSP1(19) antigens differ in their capacities to stimulate in vitro peripheral blood T lymphocytes in individuals from various endemic areas. Scand J Immunol 1999; 49: 431–40. 10.1046/j.1365-3083.1999.00511.xSearch in Google Scholar PubMed

55 Ashkar AA, Rosenthal KL. Toll-like receptor 9, CpG DNA and innate immunity. Curr Mol Med 2002; 2: 545–56. 10.2174/1566524023362159Search in Google Scholar PubMed

56 Bernasconi NL, Onai N, Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003; 101: 4500–4. 10.1182/blood-2002-11-3569Search in Google Scholar

57 Liu S, Gallo DJ, Green AM, Williams DL, Gong X, Shapiro RA, et al. Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun 2002; 70: 3433–42. 10.1128/IAI.70.7.3433-3442.2002Search in Google Scholar

58 Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374: 546–9. 10.1038/374546a0Search in Google Scholar

59 Subauste CS, de Waal Malefyt R, Fuh F. Role of CD80 (B7.1) and CD86 (B7.2) in the immune response to an intracellular pathogen. J Immunol 1998; 160: 1831–40. 10.4049/jimmunol.160.4.1831Search in Google Scholar

60 Lumsden JM, Williams JA, Hodes RJ. Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo. J Immunol 2003; 170: 781–7. 10.4049/jimmunol.170.2.781Search in Google Scholar

61 Bours V, Franzoso G, Brown K, Park S, Azarenko V, Tomita-Yamaguchi M, et al. Lymphocyte activation and the family of NF-kappa B transcription factor complexes. Curr Top Microbiol Immunol 1992; 182: 411–20. Search in Google Scholar

62 Decker T, Peschel C. Effect of immunostimulatory CpG-oligonucleotides in chronic lymphocytic leukemia B cells. Leukemia Lymphoma 2001; 42: 301–7. 10.3109/10428190109064586Search in Google Scholar

63 Bohle B. CpG motifs as possible adjuvants for the treatment of allergic diseases. Int Arch Allergy Immunol 2002; 129: 198–203. 10.1159/000066771Search in Google Scholar

64 Burdin N, Galibert L, Garrone P, Durand I, Banchereau J, Rousset F. Inability to produce IL-6 is a functional feature of human germinal center B lymphocytes. J Immunol 1996; 156: 4107–13. 10.4049/jimmunol.156.11.4107Search in Google Scholar

65 Galibert L, Burdin N, Barthelemy C, Meffre G, Durand I, Garcia E, et al. Negative selection of human germinal center B cells by prolonged BCR cross-linking. J Exp Med 1996; 183: 2075–85. 10.1084/jem.183.5.2075Search in Google Scholar

66 Galibert L, Burdin N, de Saint-Vis B, Garrone P, Van Kooten C, Banchereau J, et al. CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J Exp Med 1996; 183: 77–85. 10.1084/jem.183.1.77Search in Google Scholar

67 Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu DH, et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992; 89: 1890–3. 10.1073/pnas.89.5.1890Search in Google Scholar

68 Servet-Delprat C, Bridon JM, Blanchard D, Banchereau J, Briere F. CD40-activated human naive surface IgD+ B cells produce IgG2 in response to activated T-cell supernatant. Immunology 1995; 85: 435–41. Search in Google Scholar

69 Seydi A, Nambei WS, Goumabala M, Diadhiou F, Diouf A, Sartelet H, et al. In vitro production of immunoglobulins of various classes and subclasses by cord blood B cells in African neonates: modeling and assessment of determination. Immunol Lett 2001; 77: 119–24. 10.1016/S0165-2478(01)00204-8Search in Google Scholar

70 Beniguel L, Begaud E, Cognasse F, Gabrie P, Mbolidi CD, Marovich MA, et al. Specific antibody production by blood B cells is retained in late stage drug-naive HIV-infected Africans. Clin Dev Immunol 2004; 11: 121–7. 10.1080/10446670410001722104Search in Google Scholar PubMed PubMed Central

71 Beniguel L, Begaud E, Peruchon S, Cognasse F, Gabrie P, Marovich M, et al. Isotype profiles of anti-gp160 antibodies from HIV-infected patients in plasma and culture supernatants. Immunol Lett 2004; 93: 57–62. 10.1016/j.imlet.2004.02.004Search in Google Scholar PubMed

72 Beniguel L, Diallo TO, Remoue F, Williams DL, Cognasse F, Charrier-Mze N, et al. Differential production in vitro of antigen specific IgG1, IgG3 and IgA: a study in Schistosoma haematobium infected individuals. Parasite Immunol 2003; 25: 39–44. 10.1046/j.1365-3024.2003.00603.xSearch in Google Scholar PubMed

73 Pene J, Gauchat JF, Lecart S, Drouet E, Guglielmi P, Boulay V, et al. Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol 2004; 172: 5154–7. 10.4049/jimmunol.172.9.5154Search in Google Scholar PubMed

74 Garraud O, Perraut R, Diouf A, Nambei WS, Tall A, Spiegel A, et al. Regulation of antigen-specific immunoglobulin G subclasses in response to conserved and polymorphic Plasmodium falciparum antigens in an in vitro model. Infect Immun 2002; 70: 2820–7. 10.1128/IAI.70.6.2820-2827.2002Search in Google Scholar PubMed PubMed Central

75 Garraud O, Perler FB, Bradley JE, Nutman TB. Induction of parasite antigen-specific antibody responses in unsensitized human B cells is dependent on the presence of cytokines after T cell priming. J Immunol 1997; 159: 4793–8. 10.4049/jimmunol.159.10.4793Search in Google Scholar

76 Brandtzaeg P. The secretory immunoglobulin system: regulation and biological significance. Focusing on human mammary glands. Adv Exp Med Biol 2002; 503: 1–16. 10.1007/978-1-4615-0559-4_1Search in Google Scholar PubMed

77 Brandtzaeg P, Berstad AE, Farstad IN, Haraldsen G, Helgeland L, Jahnsen FL, et al. Mucosal immunity – a major adaptive defence mechanism. Behring Inst Mitt 1997: 1–23. Search in Google Scholar

78 Bradney CP, Sempowski GD, Liao HX, Haynes BF, Staats HF. Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization. J Virol 2002; 76: 517–24. 10.1128/JVI.76.2.517-524.2002Search in Google Scholar PubMed PubMed Central

79 Holmgren J, Harandi AM, Czerkinsky C. Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA. Expert Rev Vaccines 2003; 2: 205–17. 10.1586/14760584.2.2.205Search in Google Scholar PubMed

80 Klinman DM. CpG DNA as a vaccine adjuvant. Expert Rev Vaccines 2003; 2: 305–15. 10.1586/14760584.2.2.305Search in Google Scholar PubMed