The Risk of Venous Thromboembolism Associated with the Factor V Leiden Mutation and Low B-Vitamin Status
-
Rima Obeid
Abstract
Venous thromboembolism (VTE) is a multi-factorial disease involving numerous genetic and environmental risk factors. In this study we investigated the occurrence and the risk associated with factor V Leiden, hyperhomocysteinemia and low folate and vitamin B12 levels in young patients with thrombosis. We studied 78 patients (33 females/45 males, mean age 33 years) with a history of thrombosis in a lower limb. Additionally, 98 healthy subjects (45 females/54 males, mean age 44 years) were included. Serum levels of homocysteine (Hcy), folate and vitamin B12 were assayed. Factor V Leiden and methylenetetrahydrofolate reductase (MTHFR) C677T mutations were investigated in all subjects. Factor V Leiden was highly prevalent in the patients (39% heterozygous, 10% homozygous vs. 6.3% heterozygous in controls). An increase in the risk of idiopathic VTE was associated with Hcy levels >15.2 µmol/l (odds ratio, OR = 2.83), folate <15.1 nmol/l (OR = 7.49) and vitamin B12 <182 pmol/l (OR = 11.97). Low levels of folate or vitamin B12 were independently and strongly associated with the risk of VTE in a multivariate model (OR for idiopathic thrombosis = 16.44 and 10.76, respectively). Twenty patients (53%), carriers of factor V Leiden, had low levels of vitamin B12, compared to 28% of patients who were noncarriers of the mutation (p = 0.03). In contrast, none of the control carriers of the mutation had a low level of vitamin B12. The risk of VTE associated with lower levels of vitamin B12 and folate was stronger than that introduced by elevated Hcy levels. The increased risk of VTE, accompanied by factor V Leiden, may be related to confounding environmental factors. Clin Chem Lab Med 2003; 41(10):13571362
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- EUREGIO Congress of Clinical Chemistry and Laboratory Medicine Aachen, Germany, 8–10 October 2003
- Mitochondrial Oxidative Stress and Mitochondrial DNA
- The New European Directive on in vitro Diagnostics
- Two MMP-2 Promoter Polymorphisms (–790T/G and –735C/T) in Chronic Heart Failure
- A Common Truncated Variant of Lipoprotein Lipase in the Japanese Population Is Characterized by Pattern B Phenotype
- Effects of Acute, Heavy-Resistance Exercise on Urinary Peptide Hormone Excretion in Humans
- HMG-CoA Reductase Inhibitors Are Associated with Decreased Serum Neopterin Levels in Stable Coronary Artery Disease
- Impairment of Blood-Brain Barrier Integrity during Carotid Surgery as Assessed by Serum S-100B Protein Concentrations
- Characteristics of Prolidase from the Erythrocytes of Normal Humans and Patients with Prolidase Deficiency and Their Mother
- Reference Levels of Insulin-Like Growth Factor I in the Serum of Healthy Adults: Comparison of Four Immunoassays
- Age-Specific Analysis of Normal Cytokine Levels in Healthy Infants
- Differences between Genotyping and Phenotyping Methods for Assessing Apolipoprotein(a) Size Polymorphisms
- CYP3A4 and MDR1 Alleles in a Portuguese Population
- Common Variants in the Lipoprotein Lipase Gene in Brazil: Association with Lipids and Angiographically Assessed Coronary Atherosclerosis
- The Risk of Venous Thromboembolism Associated with the Factor V Leiden Mutation and Low B-Vitamin Status
- Analytical Evaluation of an Automated Immunoassay for Cardiac Troponin I: The Vidas Troponin I Assay
- Can Fluoride-Oxalate and Sodium Citrate Stabilise Homocysteine Levels after Blood Collection?
- Learning Curve of a New Hospital Laboratory. The Monitoring of Computer-Generated Turnaround Time of Laboratory Tests in an Emergency Department
- IFCC Handbook on Master Program in Clinical Laboratory Sciences
- Meetings and Awards
Articles in the same Issue
- EUREGIO Congress of Clinical Chemistry and Laboratory Medicine Aachen, Germany, 8–10 October 2003
- Mitochondrial Oxidative Stress and Mitochondrial DNA
- The New European Directive on in vitro Diagnostics
- Two MMP-2 Promoter Polymorphisms (–790T/G and –735C/T) in Chronic Heart Failure
- A Common Truncated Variant of Lipoprotein Lipase in the Japanese Population Is Characterized by Pattern B Phenotype
- Effects of Acute, Heavy-Resistance Exercise on Urinary Peptide Hormone Excretion in Humans
- HMG-CoA Reductase Inhibitors Are Associated with Decreased Serum Neopterin Levels in Stable Coronary Artery Disease
- Impairment of Blood-Brain Barrier Integrity during Carotid Surgery as Assessed by Serum S-100B Protein Concentrations
- Characteristics of Prolidase from the Erythrocytes of Normal Humans and Patients with Prolidase Deficiency and Their Mother
- Reference Levels of Insulin-Like Growth Factor I in the Serum of Healthy Adults: Comparison of Four Immunoassays
- Age-Specific Analysis of Normal Cytokine Levels in Healthy Infants
- Differences between Genotyping and Phenotyping Methods for Assessing Apolipoprotein(a) Size Polymorphisms
- CYP3A4 and MDR1 Alleles in a Portuguese Population
- Common Variants in the Lipoprotein Lipase Gene in Brazil: Association with Lipids and Angiographically Assessed Coronary Atherosclerosis
- The Risk of Venous Thromboembolism Associated with the Factor V Leiden Mutation and Low B-Vitamin Status
- Analytical Evaluation of an Automated Immunoassay for Cardiac Troponin I: The Vidas Troponin I Assay
- Can Fluoride-Oxalate and Sodium Citrate Stabilise Homocysteine Levels after Blood Collection?
- Learning Curve of a New Hospital Laboratory. The Monitoring of Computer-Generated Turnaround Time of Laboratory Tests in an Emergency Department
- IFCC Handbook on Master Program in Clinical Laboratory Sciences
- Meetings and Awards
