Hyperhomocysteinemia Is Related to Residual Glomerular Filtration and Folate, but not to Methylenetetrahydrofolate-Reductase and Methionine Synthase Polymorphisms, in Supplemented End-Stage Renal Disease Patients Undergoing Hemodialysis
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Wafaa Anwar
Abstract
Glomerular filtration is one of the major determinants of plasma total homocysteine (tHcy). To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects. All patients received a folate supplementation of 700 μg/day. Hyperhomocysteinemia was observed in all patients and exceeded the upper normal limit by 2-fold in 52.4% of the patients. Serum folate was significantly increased and the B12 level was not different from controls. Folate, Cystatin C and creatinine were significantly correlated to tHcy, while no correlation was found between tHcy, albumin and C-reactive protein. No difference in genotype frequency between ESRD patients and controls was found for MTHFR A1289C and MS A2756G. The MTHFR 677TT genotype was less frequent and was associated with a significantly higher tHcy level in patients. Folate and residual glomerular filtration estimated by cystatin C and creatinine levels were two independent determinants of tHcy in ESRD patients. These data suggest that hyperhomocysteinemia is a consequence as well as a complicating factor of renal failure.
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Historical Aspects and Perspectives in Homocysteine Research
- The Importance of Hyperhomocysteinemia as a Risk Factor for Diseases: An Overview
- Pre-analytical Conditions Affecting the Determination of the Plasma Homocysteine Concentration
- Total Plasma Homocysteine and Related Amino Acids in End-Stage Renal Disease (ESRD) Patients Measured by Gas Chromatography-Mass Spectrometry – Comparison with the Abbott IMx Homocysteine Assay and the HPLC Method
- Is Hyperhomocysteinemia due to the Oxidative Depletion of Folate rather than to Insufficient Dietary Intake?
- Hyperhomocysteinemia in Advanced Age
- Genetic Defects as Important Factors for Moderate Hyperhomocysteinemia
- Heterogeneity of the Association between Plasma Homocysteine and Atherothrombotic Disease: Insights from Studies of Vascular Structure and Function
- Hyperhomocysteinemia as a Risk Factor for Venous Thrombosis
- Hyperhomocysteinaemia in Patients with Peripheral Arterial Occlusive Disease
- Homocysteine, Vascular Dementia and Alzheimer's Disease
- Homocysteine in Cerebrovascular Disease: an Independent Risk Factor for Subcortical Vascular Encephalopathy
- Vascular Dysfunction in Hyperhomocyst(e)inemia. Implications for Atherothrombotic Disease
- Hyperhomocysteinemia in Chronic Renal Failure Patients: Relation to Nutritional Status and Cardiovascular Disease
- Homocysteine, Cystathionine, Methylmalonic Acid and B-Vitamins in Patients with Renal Disease
- Hyperhomocysteinemia Is Related to Residual Glomerular Filtration and Folate, but not to Methylenetetrahydrofolate-Reductase and Methionine Synthase Polymorphisms, in Supplemented End-Stage Renal Disease Patients Undergoing Hemodialysis
- Effect of Treatment of Hypothyroidism on the Plasma Concentrations of Neuroactive Steroids and Homocysteine
- Hyperhomocysteinaemia and Human Reproduction
- Homocysteine in Postmenopausal Women and the Importance of Hormone Replacement Therapy
- Does a Single Vitamin B-Supplementation Induce Functional Vitamin B-Deficiency?
- IFCC News – July 2001
Articles in the same Issue
- Historical Aspects and Perspectives in Homocysteine Research
- The Importance of Hyperhomocysteinemia as a Risk Factor for Diseases: An Overview
- Pre-analytical Conditions Affecting the Determination of the Plasma Homocysteine Concentration
- Total Plasma Homocysteine and Related Amino Acids in End-Stage Renal Disease (ESRD) Patients Measured by Gas Chromatography-Mass Spectrometry – Comparison with the Abbott IMx Homocysteine Assay and the HPLC Method
- Is Hyperhomocysteinemia due to the Oxidative Depletion of Folate rather than to Insufficient Dietary Intake?
- Hyperhomocysteinemia in Advanced Age
- Genetic Defects as Important Factors for Moderate Hyperhomocysteinemia
- Heterogeneity of the Association between Plasma Homocysteine and Atherothrombotic Disease: Insights from Studies of Vascular Structure and Function
- Hyperhomocysteinemia as a Risk Factor for Venous Thrombosis
- Hyperhomocysteinaemia in Patients with Peripheral Arterial Occlusive Disease
- Homocysteine, Vascular Dementia and Alzheimer's Disease
- Homocysteine in Cerebrovascular Disease: an Independent Risk Factor for Subcortical Vascular Encephalopathy
- Vascular Dysfunction in Hyperhomocyst(e)inemia. Implications for Atherothrombotic Disease
- Hyperhomocysteinemia in Chronic Renal Failure Patients: Relation to Nutritional Status and Cardiovascular Disease
- Homocysteine, Cystathionine, Methylmalonic Acid and B-Vitamins in Patients with Renal Disease
- Hyperhomocysteinemia Is Related to Residual Glomerular Filtration and Folate, but not to Methylenetetrahydrofolate-Reductase and Methionine Synthase Polymorphisms, in Supplemented End-Stage Renal Disease Patients Undergoing Hemodialysis
- Effect of Treatment of Hypothyroidism on the Plasma Concentrations of Neuroactive Steroids and Homocysteine
- Hyperhomocysteinaemia and Human Reproduction
- Homocysteine in Postmenopausal Women and the Importance of Hormone Replacement Therapy
- Does a Single Vitamin B-Supplementation Induce Functional Vitamin B-Deficiency?
- IFCC News – July 2001
