Evaluation of the Iron Status of the Newborn by Soluble Transferrin Receptors in Serum
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Ellen P. A. Kuiper-Kramer
Abstract
The concentration of soluble transferrin receptors in serum has proven to be a reliable predictor of iron status in adults. Its high sensitivity for iron deficiency combined with a small sample size (10 μl) makes it an interesting parameter for the assessment of iron stores in newborn infants.
In the present study we investigated the usefulness of the concentration of soluble transferrin receptors in serum in the assessment of iron metabolism in the newborn. Infants born after an uncomplicated labour were compared to infants in the intensive care unit. The concentration of soluble transferrin receptors in serum was found to be elevated compared to normal adults and independently of iron metabolism. The concentration of soluble transferrin receptors did not correlate with serum iron and ferritin concentrations. In contrast to what was found in other studies, no relationship could be demonstrated between soluble transferrin receptors and birth weight or gestational age. The results of this study have shown that care has to be taken in the interpretation of the concentration of soluble transferrin receptors in serum in newborn infants. It seems to be a parameter which is independent of iron metabolism at least during the first days of life.
Copyright © 1998 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Editorial
- Predictive Medicine
- Standardization and Clinical Management of Lipoprotein(a) Measurements
- Evaluation of the Iron Status of the Newborn by Soluble Transferrin Receptors in Serum
- Quantitation of IgG and IgM Human Anti-Mouse Antibodies (HAMA) Interference in CA 125 Measurements Using Affinity Chromatography
- Neopterin Plasma Concentrations Predict the Course of Severe Acute Pancreatitis
- Objectives, Design and Recruitment of a Familial and Longitudinal Cohort for Studying Gene-Environment Interactions in the Field of Cardiovascular Risk: The Stanislas Cohort
- Total Carbon Dioxide Measured by the Vitros Enzymatic Method
- Evaluation of Glucocard Memory 2 and Accutrend® Sensor Blood Glucose Meters
- Evaluation of Circulating Type I Procollagen Propeptides in Patients with Paget's Disease of Bone
- Properties and Units in the Clinical Laboratory Sciences XIII. Properties and Units in Reproduction and Fertility
- Procalcitonin as a Specific Marker of Bacterial Infection in Adults
- Biological Variation and Quantification of Health: The Emergence of the Concept of Normality
