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Potential biomarkers of ageing
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Andreas Simm
Veröffentlicht/Copyright:
3. März 2008
Abstract
Life span in individual humans is very heterogeneous. Thus, the ageing rate, measured as the decline of functional capacity and stress resistance, is different in every individual. There have been attempts made to analyse this individual age, the so-called biological age, in comparison to chronological age. Biomarkers of ageing should help to characterise this biological age and, as age is a major risk factor in many degenerative diseases, could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. Markers based on oxidative stress, protein glycation, inflammation, cellular senescence and hormonal deregulation are discussed.
Published Online: 2008-03-03
Published in Print: 2008-03-01
©2008 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Highlight: Oxidative Stress and Senescence
- Regulation of proteasome-mediated protein degradation during oxidative stress and aging
- Cellular responses to reactive oxygen species-induced DNA damage and aging
- Sirt1 protects the heart from aging and stress
- Klotho as a regulator of oxidative stress and senescence
- Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
- Potential biomarkers of ageing
- Increased molecular damage and heterogeneity as the basis of aging
- Modulation of longevity-associated genes by estrogens or phytoestrogens
- FoxO transcription factors in oxidative stress response and ageing – a new fork on the way to longevity?
- Studies on the expression of 6S RNA from E. coli: involvement of regulators important for stress and growth adaptation
- New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L.
- Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs
- Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional β-secretase candidate(s)
Artikel in diesem Heft
- Highlight: Oxidative Stress and Senescence
- Regulation of proteasome-mediated protein degradation during oxidative stress and aging
- Cellular responses to reactive oxygen species-induced DNA damage and aging
- Sirt1 protects the heart from aging and stress
- Klotho as a regulator of oxidative stress and senescence
- Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
- Potential biomarkers of ageing
- Increased molecular damage and heterogeneity as the basis of aging
- Modulation of longevity-associated genes by estrogens or phytoestrogens
- FoxO transcription factors in oxidative stress response and ageing – a new fork on the way to longevity?
- Studies on the expression of 6S RNA from E. coli: involvement of regulators important for stress and growth adaptation
- New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L.
- Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs
- Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional β-secretase candidate(s)
