Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies

References

Alliot, F., Rutin, J., Leenen, P.J., and Pessac, B. (1999). Brain parenchyma vessels and the angiotensin system. Brain Res.830, 101–112.10.1016/S0006-8993(99)01373-6Suche in Google Scholar

Bagnato, A., Salani, D., Di Castro, V., Wu-Wong, J.R., Tecce, R., Nicotra, M.R., Venuti. A., and Natali, P.G. (1999). Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth. Cancer Res.59, 720–727.Suche in Google Scholar

Burns, D.M., Walker, B., Gray, J., and Nelson, J. (1999). Breast cancer cell-associated endopeptidase EC 24.11 modulates proliferative response to bombesin. Br. J. Cancer79, 214–220.Suche in Google Scholar

Cassoni, P., Sapino, A., Fortunati, N., Munaron, L., Chini, B., and Bussolati, G. (1997). Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A. Int. J. Cancer72, 340–344.10.1002/(SICI)1097-0215(19970717)72:2<340::AID-IJC23>3.0.CO;2-ISuche in Google Scholar

Cassoni, P., Fulcheri, E., Carcangiu, M.L., Stella, A., Deaglio, S., and Bussolati, G. (2000). Oxytocin receptors in human adenocarcinomas of the endometrium: presence and biological significance. J. Pathol.190, 470–477.10.1002/(SICI)1096-9896(200003)190:4<470::AID-PATH550>3.0.CO;2-GSuche in Google Scholar

Chu, P., and Arber, D.A. (2000). Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma. Am. J. Clin. Pathol.113, 374–382.10.1309/8VAV-J2FU-8CU9-EK18Suche in Google Scholar

Erdös, E.G., and Skidgel, R.A. (1989). Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones. FASEB J.3, 145–151.Suche in Google Scholar

Fujii, H., Nakajima, M., Saiki, I., Yoneda, J., Azuma, I., and Tsuruo, T. (1995). Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13. Clin. Exp. Metastasis13, 337–344.10.1007/BF00121910Suche in Google Scholar

Fujimura, H., Ino, K., Nagasaka, T., Nakashima, N., Nakazato, H., Kikkawa, F., and Mizutani, S. (2000). Aminopeptidase A expression in cervical neoplasia and its relationship to neoplastic transformation and progression. Oncology58, 342–352.10.1159/000012122Suche in Google Scholar

Fujiwara, H., Imai, K., Inoue, T., Maeda, M., and Fujii, S. (1999). Membrane-bound cell surface peptidases in reproductive organs. Endocrine J.46, 11–25.10.1507/endocrj.46.11Suche in Google Scholar

Geng, Y., Biffi, A., Engelstein, D., Ronch, E., Faustini, M., Lai, H.K., Albino, A.P., Di Fronzo, G., and Nanus, D.M. (1998). Expression of the kidney-associated differentiation glycoprotein gp160 and resistance to the antitumor effects of interferon α in renal cell carcinomas. Anticancer Res.18, 1–7.Suche in Google Scholar

Glenner, G.G., McMillan, P.J., and Folk, J.E. (1962). A mammalian peptidase specific for the hydrolysis of N-terminal α-L-glutamyl and aspartyl residues. Nature194, 867.10.1038/194867a0Suche in Google Scholar

Hashida, H., Takabayashi, A., Kanai, M., Adachi, M., Kondo, K., Kohno, N., Yamaoka, Y., and Miyake, M. (2002). Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer. Gastroenterology122, 376–386.10.1053/gast.2002.31095Suche in Google Scholar

Hariyama, Y., Itakura, A., Okamura, M., Ito, M., Murata, Y., Nagasaka, T., Nakazato, H., and Mizutani, S. (2000). Placental aminopeptidase A as a possible barrier of angiotensin II between mother and fetus. Placenta21, 621–62710.1053/plac.2000.0555Suche in Google Scholar

Healy, D.P. and Wilk, S. (1993). Localization of immunoreactive glutamyl aminopeptidase in rat brain. II. Distribution and correlation with angiotensin II. Brain Res.606, 295–303.Suche in Google Scholar

Healy, D.P. and Song, L. (1999). Kidney aminopeptidase A and hypertension, Part I. Spontaneously hypertensive rats. Hypertension33, 740–745.10.1161/01.HYP.33.2.740Suche in Google Scholar

Hooper, N.M. (1994). Families of zinc metalloproteases. FEBS Lett.354, 1–6.10.1016/0014-5793(94)01079-XSuche in Google Scholar

Ikeda, N., Nakajima, Y., Tokuhara, T., Hattori, N., Sho, M., Kanehiro, H., Miyake, M. (2003). Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma. Clin. Cancer Res.9, 1503–1508.Suche in Google Scholar

Ino, K., Goto, S., Okamoto, T., Nomura, S., Nawa, A., Isobe, K., Mizutani, S., and Tomoda, Y. (1994). Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity. Jpn. J. Cancer Res.85, 927–933.10.1111/j.1349-7006.1994.tb02970.xSuche in Google Scholar

Ino, K., Goto, S., Nomura, S., Isobe, K., Nawa, A., Okamoto, T., and Tomoda, Y. (1995). Aminopeptidase inhibitor ubenimex (bestatin) inhibits the growth of human choriocarcinoma in nude mice through its direct cytostatic activity. Anticancer Res.15, 2081–2087.Suche in Google Scholar

Ino, K., Nagasaka, T., Okamoto, T., Uehara, C., Nakazato, H., Nakashima, N., and Mizutani, S. (2000a). Expression of aminopeptidase A in human gestational choriocarcinoma cell lines and tissues. Placenta21, 63–72.10.1053/plac.1999.0456Suche in Google Scholar

Ino, K., Suzuki, T., Uehara, C., Nagasaka, T., Okamoto, T., Kikkawa, F., and Mizutani, S. (2000b). The expression and localization of neutral endopeptidase 24.11/CD10 in human gestational trophoblastic diseases. Lab. Invest.80, 1729–1738.10.1038/labinvest.3780183Suche in Google Scholar

Ino, K., Uehara, C., Kikkawa, F., Kajiyama, H., Shibata, K., Suzuki, T., Khin, E.E., Ito, M., Takeuchi, M., Itakura, A., and Mizutani, S. (2003a). Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway. J. Clin. Endocrinol. Metab.88, 3973–3982.10.1210/jc.2002-021582Suche in Google Scholar

Ino, K., Kikkawa, F., Suzuki, T., Kajiyama, H., Shibata, K., Nomura, S., Itakura, A., Ito, M., Nagasaka, T., Hattori, A., Tsujimoto, M., and Mizutani, S. (2003b). Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells. Lab. Invest.83, 1799–1809.10.1097/01.LAB.0000101728.93907.75Suche in Google Scholar

Iwata, S., and Morimoto, C. (1999). CD26/dipeptidyl peptidase IV in context. The different roles of a multifunctional ectoenzyme in malignant transformation. J. Exp. Med.190, 301–306.10.1084/jem.190.3.301Suche in Google Scholar

Kajiyama, H., Kikkawa, F., Suzuki, T., Shibata, K., Ino, K., and Mizutani, S. (2002). Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma. Cancer Res.62, 2753–2757.Suche in Google Scholar

Kajiyama, H., Kikkawa, F., Khin, E.E., Shibata, K., Ino, K., and Mizutani, S. (2003). Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells. Cancer Res.63, 2278–2283.Suche in Google Scholar

Kehlen, A., Gohring, B., Langner, J., and Riemann, D. (1998). Regulation of the expression of aminopeptidase A, aminopeptidase N/CD13 and dipeptidyl peptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators. Clin. Exp. Immunol.111, 435–441.Suche in Google Scholar

Kehlen, A., Lendeckel, U., Dralle, H., Langner, J., and Hoang-Vu, C. (2003). Biological significance of aminopeptidase N/CD13 in thyroid carcinomas. Cancer Res.63, 8500–8506.Suche in Google Scholar

Keller, S.R., Scott, H.M., Mastick, C.C., Aebersold, R., and Lienhard, G.E. (1995). Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. J. Biol. Chem.270, 23612–23618.10.1074/jbc.270.40.23612Suche in Google Scholar

Kenny, A.J., O’Hare, M.J., and Gusterson, B.A. (1989). Cell-surface peptidases as modulators of growth and differentiation. Lancet2, 785–787.10.1016/S0140-6736(89)90841-6Suche in Google Scholar

Khin, E.E., Kikkawa, F., Ino, K., Suzuki, T., Shibata, K., Kajiyama, H., Tamakoshi, K., and Mizutani, S. (2003a). Neutral endopeptidase/CD10 expression in the stroma of epithelial ovarian carcinoma. Int. J. Gynecol. Pathol.22, 175–180.10.1097/00004347-200304000-00010Suche in Google Scholar

Khin, E.E., Kikkawa, F., Ino, K., Kajiyama, H., Suzuki, T., Shibata, K., Tamakoshi, K., Nagasaka, T., and Mizutani, S. (2003b). Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade. Am. J. Obstet. Gynecol.188, 670–676.10.1067/mob.2003.169Suche in Google Scholar

Kikkawa, F., Kajiyama, H., Ino, K., Watanabe, Y., Ito, M., Nomura, S., Itakura, A., Tsujimoto, M., and Mizutani, S. (2002). Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation. Placenta23, 483–489.10.1053/plac.2002.0794Suche in Google Scholar

Kikkawa, F., Mizuno, M., Shibata, K., Kajiyama, H., Morita, T., Ino, K., Nomura, S., and Mizutani, S. (2004). Activation of invasiveness of cervical carcinoma cells by angiotensin II. Am. J. Obstet. Gynecol.190, 1258–1263.10.1016/j.ajog.2003.12.013Suche in Google Scholar

Li, L., Wu, Q., Wang, J., Bucy, R.P., and Cooper, M.D. (1993). Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody. Tissue Antigens42, 488–496.10.1111/j.1399-0039.1993.tb02193.xSuche in Google Scholar

Masuda, S., Hattori, A., Matsumoto, H., Miyazawa, S., Natori, Y., Mizutani, S., and Tsujimoto, M. (2003). Involvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells. Eur. J. Biochem.270, 1988–1994.10.1046/j.1432-1033.2003.03570.xSuche in Google Scholar

Matsumoto, H., Nagasaka, T., Hattori, A., Rogi, T., Tsuruoka, N., Mizutani, S., and Tsujimoto, M. (2001). Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. Eur. J. Biochem.268, 3259–3266.10.1046/j.1432-1327.2001.02221.xSuche in Google Scholar

Mitsui, T., Nomura, S., Okada, M., Ohno, Y., Kobayashi, H., Nakashima, Y., Murata, Y., Takeuchi, M., Kuno, N., Nagasaka, T., Wang, J., Cooper, M.D., and Mizutani, S. (2003). Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice. Mol. Med.9, 57–62.10.1007/BF03402108Suche in Google Scholar

Mizokami, Y., Kajiyama, H., Shibata, K., Ino, K., Kikkawa, F., and Mizutani, S. (2004). Stromal cell-derived factor 1α-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma. Int. J. Cancer110, 652–659.10.1002/ijc.20183Suche in Google Scholar

Mizutani, S., Okano, K., Hasegawa, E., Sakura, H., and Yamada, M. (1981). Aminopeptidase A in human placenta. Biochem. Biophys. Acta678, 168–170.10.1016/0005-2744(81)90240-0Suche in Google Scholar

Mizutani, S., Akiyama, H., Kurauchi, O., Taira, H., Narita, O., and Tomoda, Y. (1985). In vitro degradation of angiotensin II (A-II) by human placental subcellular fractions, pregnancy sera and purified placental aminopeptidases. Acta Endocrinol.110, 135–l39.10.1530/acta.0.1100135Suche in Google Scholar

Mizutani, S., Goto, K., Itakura, A., Furuhashi, M., Kurauchi, O., Kikkawa, F., and Tomoda, Y. (1994). Physiological role of placental proteases: interaction between pregnancy-induced bioactive peptides and proteases. Endocrine J.41 (Suppl.), S93–S104.10.1507/endocrj.41.Supplement_S93Suche in Google Scholar

Mizutani, S., and Tomoda, Y. (1996). Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsia. Am. J. Hypertens.9, 591–597.10.1016/0895-7061(96)00016-7Suche in Google Scholar

Morita, T., Shibata, K., Kikkawa, F., Kajiyama, H., Ino, K., and Mizutani, S. (2004). Oxytocin inhibits the progression of human ovarian carcinoma cells in vitro and in vivo. Int. J. Cancer109, 525–532.10.1002/ijc.20017Suche in Google Scholar PubMed

Nadal, J.A., Scicli, G.M., Carbini, L.A., and Scicli, A.G. (2002). Angiotensin II stimulates migration of retinal microvascular pericytes: involvement of TGF-β and PDGF-BB. Am. J. Physiol. Heart Circ. Physiol.282, H739–H748.10.1152/ajpheart.00656.2001Suche in Google Scholar PubMed

Nagasaka, T., Nomura, S., Okamura, M., Tsujimoto, M., Nakazato, H., Oiso, Y., Nakashima, N., and Mizutani, S. (1997). Immunohistochemical localization of placental leucine aminopeptidase/oxytocinase in normal human placental, fetal and adult tissues. Reprod. Fertil. Dev.9, 747–753.10.1071/R97055Suche in Google Scholar PubMed

Nanus, D.M. (2003). Of peptides and peptidases: the role of cell surface peptidases in cancer. Clin. Cancer Res.9, 6307–6309.Suche in Google Scholar

Nanus, D.M., Engelstein, D., Gastl, G.A., Gluck, L., Vidal, M.J., Morrison, M., Finstad, C.L., Bander, N.H., and Albino, A.P. (1993). Molecular cloning of the human kidney differentiation antigen gp 160: human aminopeptidase A. Proc. Natl. Acad. Sci. USA90, 7069–7073.10.1073/pnas.90.15.7069Suche in Google Scholar PubMed PubMed Central

Nanus, D.M., Bogenrieder, T., Papandreou, C.N., Finstad, C.L., Lee, A., Vlamis, V., Motzer, R.J., Bander, N.H., Albino, A.P., and Reuter, V.E. (1998). Aminopeptidase A expression and enzymatic activity in primary human renal cancers. Int. J. Oncol.13, 26l–267.10.3892/ijo.13.2.261Suche in Google Scholar PubMed

Nomura, M., Tsukahara, S., Ando, H., Katsumata, Y., Okada, M., Itakura, A., Nomura, S., Kikkawa, F., Nagasaka, T., and Mizutani, S. (2002). Differential distribution of placental leucine aminopeptidase/oxytocinase and aminopeptidase A in human trophoblasts of normal placenta and complete hydatidiform mole. Placenta23, 631–639.10.1053/plac.2002.0861Suche in Google Scholar PubMed

Papandreou, C.N., Usmani, B., Geng, Y., Bogenrieder, T., Freeman, R., Wilk, S., Finstad, C.L., Reuter, V.E., Powell, C.T., Scheinberg, D. et al. (1998). Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression. Nat. Med.4, 50–57.Suche in Google Scholar

Pasqualini, R., Koivunen, E., Kain, R., Lahdenranta, J., Sakamoto, M., Stryhn, A., Ashmun, R.A., Shapiro, L.H., Arap, W., and Ruoslahti, E. (2000). Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res.60, 722–727.Suche in Google Scholar

Richard, D.E., Vouret-Craviari, V., and Pouyssegur, J. (2001). Angiogenesis and G-protein-coupled receptors: signals that bridge the gap. Oncogene20, 1556–1562.10.1038/sj.onc.1204193Suche in Google Scholar PubMed

Rogi, T., Tsujimoto, M., Nakazato, H., Mizutani, S., and Tomoda, Y. (1996). Human placental leucine aminopeptidase/oxytocinase: a new member of type II membrane-spanning zinc metallopeptidase family. J. Biol. Chem.271, 56–61.10.1074/jbc.271.1.56Suche in Google Scholar

Rosano, L., Varmi, M., Salani, D., Di Castro, V., Spinella, F., Natali, P.G., and Bagnato, A. (2001). Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells. Cancer Res.61, 8340–8346.Suche in Google Scholar

Saiki, I., Fujii, H., Yoneda, J., Abe, F., Nakajima, M., Tsuruo, T., and Azuma, I. (1993). Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation. Int. J. Cancer54, l37–l43.10.1002/ijc.2910540122Suche in Google Scholar

Salani, D., Di Castro, V., Nicotra, M.R., Rosano, L., Tecce, R., Venuti, A., Natali, P.G., and Bagnato, A. (2000). Role of endothelin-1 in neovascularization of ovarian carcinoma. Am. J. Pathol.157, 1537–1547.10.1016/S0002-9440(10)64791-8Suche in Google Scholar

Schlingemann, R.O., Oosterwijk, E., Wesseling, P., Rietveld, F.J., and Ruiter, D.J. (1996). Aminopeptidase A is a constituent of activated pericytes in angiogenesis. J. Pathol.179, 436–442.10.1002/(SICI)1096-9896(199608)179:4<436::AID-PATH611>3.0.CO;2-ASuche in Google Scholar

Shibata, K., Kikkawa, F., Suzuki, Y., Mizokami, Y., Kajiyama, H., Ino, K., Nomura, S., Nagasaka, T., and Mizutani, S. (2004). Expression of placental leucine aminopeptidase is associated with poor outcome in endometrial endometrioid adenocarcinoma. Oncology66, 288–295.10.1159/000078329Suche in Google Scholar

Shipp, M.A. and Look, A.T. (1993). Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood82, 1052–1070.10.1182/blood.V82.4.1052.bloodjournal8241052Suche in Google Scholar

Shipp, M.A., Vijayaraghavan, J., Schmidt, E.V., Masteller, E.L., D’Adamio, L., Hersh, L.B., and Reinherz, E.L. (1989). Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 (‘enkephalinase’): direct evidence by cDNA transfection analysis. Proc. Natl. Acad. Sci. USA86, 297–301.Suche in Google Scholar

Shipp, M.A., Tarr, G.E., Chen, C.Y., Switzer, S.N., Hersh, L.B., Stein, H., Sunday, M.E., and Reinherz, E.L. (1991). CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc. Natl. Acad. Sci. USA88, 10662–10666.Suche in Google Scholar

Song, L., Ye, M., Troyanovskaya, M., Wilk, E., Wilk, S., and Healy, D.P. (1994). Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization. Am. J. Physiol.267, F546–F557.10.1152/ajprenal.1994.267.4.F546Suche in Google Scholar

Suganuma, T., Ino, K., Shibata, K., Nomura, S., Kajiyama, H., Kikkawa, F., Tsuruoka, N., and Mizutani, S. (2004). Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor. Lab. Invest.84, 639–648.10.1038/labinvest.3700072Suche in Google Scholar

Suzuki, T., Kikkawa, F., Ino, K., Nagasaka, T., Tamakoshi, K., and Mizutani, S. (2001). Imbalance between neutral endopeptidase 24.11 and endothelin-1 expression in human endometrial carcinoma. Oncology60, 258–267.Suche in Google Scholar

Suzuki, T., Ino, K., Kikkawa, F., Uehara, C., Kajiyama, H., Shibata, K., and Mizutani, S. (2002). Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway. Placenta23, 475–482.10.1053/plac.2002.0820Suche in Google Scholar

Suzuki, Y., Shibata, K., Kikkawa, F., Kajiyama, H., Ino, K., Nomura, S., Tsujimoto, M., and Mizutani, S. (2003). Possible role of placental leucine aminopeptidase in the antiproliferative effect of oxytocin in human endometrial adenocarcinoma. Clin. Cancer Res.9, 1528–1534.Suche in Google Scholar

Toda, S., Ando, H., Nagasaka, T., Tsukahara, S., Nomura, M., Kotani, Y., Nomura, S., Kikkawa, F., Tsujimoto, M., and Mizutani, S. (2002). Existence of placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase in human endometrial epithelial cells. J. Clin. Endocrinol. Metab.87, 1384–1389.10.1210/jcem.87.3.8306Suche in Google Scholar

Touyz, R.M., Deng, L.Y., He, G., Wu, X.H., and Schiffrin, E.L. (1999). Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases. J. Hypertens.17, 907–916.10.1097/00004872-199917070-00006Suche in Google Scholar

Tsujimoto, M., Mizutani, S., Adachi, H., Kimura, M., Nakazato, H., and Tomoda, Y. (1992). Identification of human placental leucine aminopeptidase as oxytocinase. Arch. Biochem. Biophys.292, 388–392.10.1016/0003-9861(92)90007-JSuche in Google Scholar

Uehara, C., Ino, K., Suzuki, T., Kajiyama, H., Kikkawa, F., Nagasaka, T., and Mizutani, S. (2001). Upregulation of neutral endopeptidase expression and enzymatic activity during the differentiation of human choriocarcinoma cells. Placenta22, 540–549.10.1053/plac.2001.0694Suche in Google Scholar PubMed

Wesley, U.V., Albino, A.P., Tiwari, S., and Houghton, A.N. (1999). A role for dipeptidyl peptidase IV in suppressing the malignant phenotype of melanocytic cells. J. Exp. Med.190, 311–322.10.1084/jem.190.3.311Suche in Google Scholar PubMed PubMed Central

Wu, Q., Lahti, J.M., Air, G.M., Burrows, P.D., and Cooper, M.D. (1990). Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family. Proc. Natl. Acad. Sci. USA87, 993–997.10.1073/pnas.87.3.993Suche in Google Scholar PubMed PubMed Central

Zini, S., Fournie-Zaluski, M.C., Chauvel, E., Roques, B.P., Corvol, P., and Llorens-Cortes, C. (1996). Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release. Proc. Natl. Acad. Sci. USA93, 11968–11973.10.1073/pnas.93.21.11968Suche in Google Scholar PubMed PubMed Central