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Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice
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J. Rüter
Published/Copyright:
June 1, 2005
Abstract
We assessed changes of the enzyme dipeptidyl peptidase IV (DPP IV, CD26) in the context of leptin or leptin receptor deficiency. C57BL/6 mice, Leptin-deficient mice (ob/ob mice, B6.VLep<ob>) and Leptin-receptor-deficient mice (db/db mice, B6.Cgm+/+Lepr) were infected with B. Calmette-Guérin (BCG) and sacrificed three days later. DPP IV activity in serum was higher in ob/ob mice and in db/db mice than in wildtype mice. The expression of DPP IV/CD26 on splenocytes was higher in ob/ob mice than in wildtype animals, and lower in db/db mice, and decreased upon stimulation with BCG in ob/ob mice only. Several T cell antigens including CTLA-4 were expressed aberrantly in ob/ob and in db/db mice. Our observations provide evidence for a relationship between DPP IV and leptin.
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Published Online: 2005-06-01
Published in Print: 2004-06-07
Copyright © 2004 by Walter de Gruyter GmbH & Co. KG
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- Highlight: 3rd General IPS Meeting/International Conference on Protease inhibitors
- Colon cancer: genomics and apoptotic events
- Interaction of calpastatin with calpain: a review
- Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones
- Searching for the most effective screening system to identify cell-active inhibitors of β-secretase
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- Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors
- Human cathepsin F: expression in baculovirus system, characterization and inhibition by protein inhibitors
- Proteinases participating in the processing and activation of prolegumain in primary cultured rat macrophages
- Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation
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