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The Eukaryotic Gene Transcription Machinery
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Roger D. Kornberg
Published/Copyright:
June 1, 2005
Abstract
Seven purified proteins may be combined to reconstitute regulated, promoterdependent RNA polymerase II transcription: five general transcription factors, Mediator, and RNA polymerase II. The entire system has been conserved across species from yeast to humans. The structure of RNA polymerase II, consisting of 10 polypeptides with a mass of about 500 kDa, has been determined at atomic resolution. On the basis of this structure, that of an actively transcribing RNA polymerase II complex has been determined as well.
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Published Online: 2005-06-01
Published in Print: 2001-08-28
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Roger D. Kornberg Felix Hoppe-Seyler Lecturer 2001
- The Eukaryotic Gene Transcription Machinery
- Paper of the Year 2000: Award to Eva Estébanez-Perpiñá and Pablo Fuentes-Prior
- GABAC Receptors: A Molecular View
- Recent Advances in Plant MAP Kinase Signalling
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- Binding of IRE-BP to Its Cognate RNA Sequence: SFM Studies on a Universal RNA Backbone for the Analysis of RNA-Protein Interaction
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